【생물학】 바이오마커

바이오마커

 

추천글 : 【생물학】 생물학 목차

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1. B2M mutations (rare)
1. Association : -
2. phase III validation : TBD
3. predictive
4. melanoma
5. biomarker assessment : tumour tissue or blood
6. NGS WES or targeted gene panel sequencing
2. Copy number variation
1. Association : -
2. phase III validation : TBD
3. prognostic, predictive
4. multiple cancer types
5. biomarker assessment : tumour tissue
6. NGS WES or targeted gene panel sequencing
3. Gut microbial diversity
1. Association : +
2. phase III validation : TBD
3. predictive
4. melanoma
5. biomarker assessment : Oral or gut
6. PCR or NGS
4. HLA class I diversity
1. Association : +
2. phase III validation : TBD
3. predictive
4. melanoma and NSCLC
5. biomarker assessment : blood
6. NGS WES or PCR-based typing
5. JAK2 mutations (rare)
1. Association : -
2. phase III validation : TBD
3. predictive
4. melanoma
5. biomarker assessment : tumour tissue or blood
6. NGS WES or targeted gene panel sequencing
6. LOH at HLA class I alleles
1. Association : -
2. phase III validation : TBD
3. predictive
4. melanoma
5. biomarker assessment : tumour tissue
6. TBD
7. Mutations in the β-catenin pathway
1. Association : -
2. phase III validation : TBD
3. predictive
4. melanoma
5. biomarker assessment : tumour tissue or blood
6. NGS WES, targeted gene panel sequencing or RNA-seq
8. PDL1
1. Association : +
2. phase III validation : Y
3. predictive
4. multiple cancer type
5. biomarker assessment : tumour tissue
6. immunohistochemistry
9. SERPINB3 or SERPINB4 mutations
1. Association : +
2. phase III validation : TBD
3. predictive
4. melanoma
5. biomarker assessment : tumour tissue
6. NGS WES
10. Specific gut microbial species
1. Association : + or -
2. phase III validation : TBD
3. predictive
4. melanoma
5. biomarker assessment : oral or gut
6. PCR or NGS
11. STK11 mutation (common)
1. Association : -
2. phase III validation : TBD
3. predictive
4. NSCLC
5. biomarker assessment : tumour tissue or blood
6. NGS WES or targeted gene panel sequencing
12. T cell-inflamed microenvironment
1. Association : +
2. phase III validation : TBD
3. prognostic, predictive
4. mutiple cancer types
5. biomarker assessment : tumour tissue
6. NGS RNA-seq or immunostaining
13. T cell repertoire clonality change 
1. Association : +
2. phase III validaiton : TBD
3. predictive
4. melanoma
5. biomarker assessment : tumour tissue or blood
6. TBD
14. TGFβ expression
1. Association : -
2. phase III validation : TBD
3. predictive
4. colon cancer and urothelial cancer
5. biomarker assessment : tumour tissue
6. NGS RNA-seq or expression panel
15. Tumour mutation burden 
1. Association : +
2. phase III validation : Y
3. predictive
4. multiple cancer type
5. biomarker assessment : blood or tumour tissue
6. NGS WES or targeted gene panel sequencing

 

입력: 2025.03.23 17:58