【생물학】 p53 (TP53)

p53 (TP53)

 

추천글 : 【생물학】 1-2강. 생체고분자 라이브러리 

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1. p53 타겟 유전자 

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1. p53 타겟 유전자  

⑴ p53 antagonist

① MDM2 / HDM2 : induces p53 ubiquitylation 

⑵ growth arrest gene

① p21^Cip1 : inhibitor of CDKs, DNA polymerase 

② Siah-1 : aids β-catenin degradation 

③ 14-3-3σ : sequesters cyclin B-CDC2 in cytoplasm

④ Reprimo : G₂ arrest 

⑶ DNA repair gene 

① p53R2 : ribonucleotide reductase - biosynthesis of DNA precursors 

② XPE / DDB2 : global NER

③ XPC : global NER 

④ XPG : global NER, TCR

⑤ GADD45 : global NER 

⑥ DNA pol κ : error-prone DNA polymerase 

⑷ regulator of apoptosis 

① BAX : mitochondial pore protein 

② PUMA : BH3-only mitochondrial pore protein

③ NOXA : BH3-only mitochondrial pore protein 

④ p53AIP1 : dissipates mitochondrial membrane potential 

⑤ Killer / DR5 : cell surface death receptor 

⑥ PIDD : death domain protein 

⑦ PERP : pro-apoptotic transmembrane protein 

⑧ APAF1 : activator of caspase-9

⑨ NK-κB : transcription factor, mediator of TNF signaling 

⑩ Fas / APO1 : death receptor 

⑪ PIG3 : mitochondrial oxidation / reduction control 

⑫ PTEN : reduces levels of the anti-apoptotic PIP₃ 

⑬ Bcl-2 : (repression of) its expression 

⑭ IGF-1R : (repression of) its expression 

⑮ IGFBP-3 : IGF-1-sequestering protein

⑸ anti-angiogenic protein 

① TSP-1 (thrombospondin) : antagonist of angiogenesis 

 

입력: 2023.08.23 22:48