【생물정보학】 셀 타입 마커 유전자

셀 타입 마커 유전자(cell type marker genes)

추천글 : 【생물정보학】 생물정보학 분석 목차

1. 개요 [본문]

2. 유형 1. 상피세포 [본문]

3. 유형 2. 내피세포 [본문]

4. 유형 3. 면역세포 [본문]

5. 유형 4. 기질세포 [본문]

5. 유형 5. 기타 [본문]

a. 유전자 라이브러리

b. 유전자 스코어 라이브러리

c. 리간드-수용체 상호작용 데이터베이스

1. 개요 [목차]

⑴ 인간의 몸은 400 종류 이상의 세포로 구성

⑵ 유전자를 지칭할 때는 이탤릭체로 표현하고, 유전자의 단백질 산물을 표현할 때에는 정자체로 표현함

① 단, 여기에서는 정자체로 통일하기로 함

⑶ Homo sapiens (human)

① 유전자는 전부 대문자

② GRCh38 레퍼런스 기준 36601개 (ENSG)

human_genes_36601.tsv

0.89MB

⑷ Mus musculus (mouse)

① 유전자 첫 글자만 대문자이고 나머지는 소문자

② mm10 레퍼런스 기준 32285개 (ENSMUSG)

mouse_genes_32285.tsv

0.85MB

⑸ 사람과 마우스 유전자의 상동

⑹ 실제로는 단순히 발현이 높은 것(high)과 발현이 설령 낮더라도 exclusive하게 발현하는 것(+)을 구분하는 게 일반적

⑺ 자료 1. Tabula Sapiens : 기본적으로 다음 셀 타입 리스트는 Tabula Sapiens를 기반으로 함 (file)

Figure. 1. Tabula Sapiens

⑻ 자료 2. Tabula Muris (ref, file)

⑼ 자료 3. Tabula Microcebus (file)

⑽ 자료 4. 아래 마커 유전자에서 실제 데이터에 적용할 때 사용할 마커 유전자를 추출하는 방법은 sc-type 알고리즘을 참고 (file)

⑾ 자료 5. PanglaoDB (file)

⑿ 자료 6. SCEVAN (file)

⒀ 자료 7. 조직별 상대적 셀 분포 (file)

⒁ 자료 8. CellMarker 2.0 (file)

⒂ 자료 9. HCA (Human Cell Atlas)

⒃ 자료 10. CCLE (ref, file)

⒄ 자료 11. cellxgene 데이터베이스 : CL:0001061과 같은 정보는 다음 파일 혹은 링크에서 확인 가능

cl.obo.txt

0.86MB

⒅ 자료 12. 기타 부족한 정보는 수십억 개의 논문을 큐레이션 한 https://typeset.io/, https://www.scinapse.io/를 참고할 수 있음

2. 유형 1. epithelial cell (상피세포) [목차]

⑴ 개요 : pan-epithelial cell

① (+) EPCAM, KRT19, Epcam, Krt8, ANKRD30A, MUC6, MYBPC1

② (+) PATE4, SEMG1, PRPS2, SEMG2, ENPP3, FADS2, GSTM3, ABCG2, ELF5, PNMT (Tabula Sapiens)

③ (+) 4833423E24Rik, Krt33b, Cryba2, Bnc1, Krtap3-2, Sox21, Nmu, Gabrp, Clca4, Krt75 (Tabula Muris)

④ (+) CD24, CEACAM1, AGR2, GPA33, CEACAM5, SFN, TSTD1, PIGR, MUC13, SELENBP1, ELF3, TSPAN1, GUCA2A, PHGR1, LGALS4, TSPAN8, VSIG2, EPCAM (PanglaoDB)

⑵ adrenal cortex epithelium

① 종류 1. zona glomerulosa epithelial cell

○ (+) Akr1b7, Star

⑶ basal cell

① (+) KRT5, KRT14, KRT19, TP63

② (+) PTPRZ1, TP63, DSC3, KRT14, S100A2, CLCA2, MIR205HG, KRT15, EXPH5, DENND2C (Tabula Sapiens)

③ (+) KRT5, KRT17, ANXA11, PLAU, SRSF4, KRT23, ITGA2, RAB13, LAMB3, ACADVL, HEBP2, KRT15, PLP2, MT1X, S100A14 (PanglaoDB)

⑷ brain epithelium

① 종류 1. brain cancer cell epithelium

○ (+) CD44, MBTPS2, PARP1 (sc-type)

② 종류 2. brain cancer stem cell

○ (+) FUT4, MSI1, NES, PROM1, SOX2, THY1 (sc-type)

③ 종류 3. choroid plexus cell

○ (+) Clic6

④ 종류 4. anterior pituitary gland cell

⑤ 종류 5. ependymal cell

○ (+) Ccdc153

○ (+) FOXJ1, ENKUR, FAM216B, DNAH12, IQCG, SPEF2, ODF3B, TEKT1, LRRC23, PIFO, DYNLRB2, RSPH1, CCDC153, ZMYND10, CFAP44 (PanglaoDB)

⑥ 종류 6. meningeal cell

⑦ 종류 7. tancyte

⑧ 종류 8. cerebral cortex layer

○ 8-1. white matter

○ (+) MOBP

○ 8-2. gray matter

○ (+) SNAP25

○ 8-3. L6

○ (+) KRT17

○ 8-4. L5

○ (+) PCP4

○ 8-5. L4

○ (+) RORB

○ 8-6. L3

○ (+) RORB, CUX2, HPCAL1

○ 8-7. L2

○ (+) RORB, CUX2

○ 8-8. L1

○ (+) RELN

⑨ 종류 9. corpus callosum

○ (+) Car2

⑸ cancer epithelium

① (+) CD44, EPCAM, ERBB2, FOLH1, KRT18, PROM1, KIT, CLDN4

② CCRCC(clear cell renal cell carcinoma)

③ ovarian cancer

④ endometrial cancer

⑤ B16F10

○ (+) DCT, PMEL, TYRP1, MLANA

⑥ EMT6

○ (+) RBP1, CRABP2

⑦ LL2

○ (+) RPL29, KRT18

⑧ CT26

○ (+) BAIAP2L1, RPL39L

⑨ MC38

○ (+) FAM159B, SNHG9

⑩ SA1N

○ (+) ITIH3

⑪ brain cancer cell epithelium

○ (+) CD44, MBTPS2, PARP1 (sc-type)

⑫ brain cancer stem cell

○ (+) FUT4, MSI1, NES, PROM1, SOX2, THY1 (sc-type)

⑬ breast cancer epithelium

○ (+) ABCC11, APOBEC3B, AR, CAV1, CCND1, CDH1, CEACAM6, CENPF, CXCL12, EGFR, ERBB2, ESR1, FOXA1, GATA3, KIT, KRT7, LDHB, LRRC15, MDM2, MKI67, PCLAF, PGR, PTGDS, RUNX1, S100A4, SCD, SFRP1, SNAI1, TACSTD2, TCF4, TOP2A, ZEB1, ZEB2

⑭ 주요 암종 바이오마커

Figure. 2. 주요 암종 바이오마커

⑹ ciliated epithelial cell

① (+) FOXJ1, PAEP, UCA1, SCGB1D2, RP11-519G16.5, DCDC2, C2orf88, LAMC2, SCGB2A1, OCLN (Tabula Sapiens)

⑺ eye epithelium

① 종류 1. corneal epithelial cell

○ (+) KRT3, KLF6 (sc-type)

○ (+) KRT12, MUC22, MGARP, CTSV, ERICH5, RP11-96L14.7, CRTAC1, KRT3, RAET1L, CREG2 (Tabula Sapiens)

② 종류 2. corneal keratocyte

○ (+) LEPR, LCN1, LACRT, FOXL2, NTRK2, OGN, BOC, CHRDL1, OMD, NECAB1 (Tabula Sapiens)

③ 종류 3. 광수용기 세포(photoreceptor cell)

○ (+) RBP3, RS1, KCNV2, IMPG1, RDH8, RTBDN, RP11-442N1.1, PDC, CPLX4, RP11-6E9.5 (Tabula Sapiens)

○ 3-1. rod photoreceptor cell

○ (+) Rho, Pdc, NRL, ROM1, CRX, ARR3, CABP4, CACNA1D, DYNLRB2, EDN2, FRMPD2, GJD2, KCNQ5, KCNA4, LRIT1, LRIT2, MAF, MED1, RORB, RP1L1, TSPAN10, TTC8, Gcap2, Samd7, Cerkl, SAMD11, SLC24A1, RP1, PDE6B (sc-type)

○ 3-2. cone photoreceptor cell

○ (+) Arr3, Opn1sw, NRL, ROM1, CRX, ARR3, OPN1LW, OPN1MW, CABP4, CACNA1D, EDN2, GJD2, GNB3, KCNQ5, LRIT1, MED1, RP1L1, THRB, TSPAN10, TTC8, Opmw, SLC24A1, RP1, PDE6B (sc-type)

④ 종류 4. ocular surface cell

⑤ 종류 5. retinal pigment epithelial cell

○ (+) EZR, RPE65, BEST1, ANO2, BMP2, BMP4, CLU, EFEMP1, IL4, KCNJ5, MED1, RDH5, RGR, SBSPON, TGFBR1, TMEM98, TTC8, TRAF1, Cerkl (sc-type)

○ (+) AC067969.2, RPE65, ITGAV, LINC00276, TMEM98, BEST1, FHIT, RBP1, RLBP1, ITGB8 (Tabula Sapiens)

⑥ 종류 6. cancer cell

○ (+) EPCAM (sc-type)

⑦ 종류 7. uveal tract cell

⑧ 종류 8. Schwalbe line cell

⑻ gland

① 종류 1. acinar cell of salivary gland

○ (+) BPIFA2, LPO, PRB2, CA6, PRB1, MUCL1, PRH1, PRB4, PRH2, HTN1 (Tabula Sapiens)

② 종류 2. duct epithelial cell

○ (+) TFCP2L1, ANKRD36C, FOLR1, SCGB3A1, CALML5, DMBT1, LRRC26, AZGP1, CCL28, TCN1 (Tabula Sapiens)

③ 종류 3. duodenum glandular cell

○ (+) TFF2, LIPF, C6orf58, GOLM1, A4GNT, KCNE2, FUT9, PGC, AGR2, SCG5 (Tabula Sapiens)

④ 종류 4. epithelial cell of lacrimal sac

○ (+) SMR3A, PROL1, DCT, LCN1, LINC01474, LACRT, ANGPTL7, KRT12, RP11-54H7.4, PLCB4 (Tabula Sapiens)

⑤ 종류 5. lacrimal gland functional unit cell

⑥ 종류 6. luminal epithelial cell of mammary gland

○ (+) SERPINA3, EGLN3, PRSS8, ANGPTL4, HILPDA, ITGB6, RP5-857K21.6, EFHD1, SERINC2, DSG2 (Tabula Sapiens)

○ (+) KRT18, SLPI, KRT19, CD74, AGR2, SERPINB3, WFDC2, LCN2, BTG1, CLDN4, ANXA1, HMGA1, TNFSF10, HIF1A, CEBPD, KRT8, CD9, AQP3, CDH1, MUC1 (PanglaoDB)

⑦ 종류 7. mucus secreting cell

○ (+) MUC5AC, BPIFA1, MUC5B, ANKRD36C, BPIFB1, LINC00342, SLC5A8, MUC4, SLC26A4, TMC5 (Tabula Sapiens)

⑧ 종류 8. salivary gland cell

○ (+) Gstm1, Wfdc18

○ (+) CENPF, NEK2, DEPDC1, TOP2A, MKI67, ANLN, IQGAP3, HMMR, MUC7, KLK5 (Tabula Sapiens)

⑨ 종류 9. secretory cell

○ (+) ATP12A, MUC4, SERPINB3, CXCL17, TSPAN1, MUC16, VMO1, ALOX15, CEACAM5, MAL2

⑩ 종류 10. stratified squamous epithelium from the oral mucosa

○ (+) Krt5, Krt15

⑪ 종류 11. mammary epithelial cell

○ (+) SERPINB5, KRT5, CLDN4, KRT17, NEDD9, KRT19, KRT7, KRT8, KRT18 (PanglaoDB)

⑫ 종류 12. parathyroid gland

○ 12-1. oxyphil cell

○ 12-2. parathyroid chief cell

⑬ 종류 13. breast glandular cell

○ (+) ADAM9, AGR3, ALDH1A3, AQP3, BACE2, C15orf48, C5orf46, CCDC6, CD9, CDC42EP1, CLIC6, CTTN, DAPK3, DMKN, DNTTIP1, DSC2, EIF4EBP1, ENAH, FASN, FLNB, HMGA1, HOOK2, HPX, JUP, KRT23, LYPD3, MLPH, MYO5B, OCIAD2, OPRPN, PIGR, PTRHD1, QARS, S100A14, SCGB2A1, SDC4, SERHL2, SERPINA3, SH3YL1, SLC25A37, SLC5A6, SMS, SQLE, SRPK1, SVIL, TCIM, TMEM147, TOMM7, TPD52, TRAPPC3, USP53, ZNF562

⑼ hepatic epithelium

① 종류 1. 담관세포(cholangiocyte) : 담즙의 통로

○ (+) SSTR2, SLC4A2, KRT7, KCNN2, ITGB4, GGT6, CFTR, AQP4, AQP1, PIGR, GGT1, JAG1, GPBAR1, GGT7, KRT19, ONECUT2, ALPL, HNF1B, ALB, AGR2, TFF3, TFF1, SOX9, EPCAM, CLDN4, MMP7, TFF2, SCGB3A1, FXYD2, DEFB1, CD24, LCN2, CXCL1, CXCL6, LGALS2, TACSTD2, ELF3, SPP1, MUC5B, LGALS4, KRT8 (sc-type)

○ (+) CHST4, FGFR2, GC, TM4SF4, APCS, AMBP, AGT, SLC17A4, SEMA3E, CXCL6 (Tabula Sapiens)

○ (+) PIGR, KRT19, AGR2, TFF3, EPCAM, CLDN4, CD24, LCN2, ELF3, LGALS4 (PanglaoDB)

② 종류 2. cancer stem cell

○ (+) ANPEP, CD44, EPCAM, POU5F1, PROM1, THY1

⑽ intestinal epithelial cell

① (+) TRDC

② (+) UNC5CL, C1orf177, TRIM31, LINC00955, RP3-417L20.4, HMGN1P20, ALPI, RP11-395B7.2, EGFR-AS1, RP11-462G2.1, DEFB1, CA7, RP11-468N14.13, ARL14, AC024592.9 (sc-type)

③ 종류 1. enterocyte of epithelium of large intestine

○ (+) 2610528A11Rik

○ (+) MUC12, NXPE1, CLDN3, PHGR1, CDX1, MUC13, RP11-357H14.17, FXYD3, LGALS4, CDH17 (Tabula Sapiens)

④ 종류 2. enterocyte of epithelium of small intestine

○ (+) RBP2, CCL25, MUC17, PRAP1, CGN, SI, ARL14, FABP2, EPS8L3, CDHR5 (Tabula Sapiens)

⑤ 종류 3. paneth cell of epithelium of large intestine

⑥ 종류 4. paneth cell of epithelium of small intestine

○ (+) GOLM1, CTSE, ANXA10, ONECUT2, CDHR5, TSPAN8, CDHR2, KRT20, MUC3A, SLC5A1 (Tabula Sapiens)

⑦ 종류 5. paneth cell of colon

○ (+) CA7, OTOP2, BEST4, GUCA2A, FRMD1, SPIB, CLDN3, HEPACAM2, KRT20, SDCBP2 (Tabula Sapiens)

⑧ 종류 6. serous cell of epithelium of bronchus

○ (+) C6orf58, CXCL17, CCDC129, LINC01482, PRR4, BPIFB1, DMBT1, ATP12A, TCN1, GLYATL2 (Tabula Sapiens)

⑨ 종류 7. serous cell of epithelium of trachea

○ (+) GLYATL2, BPIFB1, PROM1, MUC5B, BPIFA1, TMC5, SCGB3A1, AGR2, DMBT1, FCGBP (Tabula Sapiens)

⑩ 종류 8. mesothelial cell

○ (+) AP000705.7, HAS1, TNNT1, BNC1, DSC3, WT1, WNT10A, C21orf62, PTPRQ, CEMP1, C3, CRB2, KLK11, PHYHIP, TGM1 (sc-type)

⑪ 종류 9. BEST4+ cell

⑫ 영역 1. villus tip

○ (+) CREB3L3, KLF6, ATF3, JUN, ACE2, MEP1A/B, DEFB1 (antimicrobial peptide), chylomicron assembly (MTTP, APOB, DGAT2), BMP molecules (BMP8A, BMP8AB), non-canonical WNT ligand (WNT5A), gene markers of γδ T/NK (TRDC, GZMA, GZMB)

○ 1-1. villus tip in mouse

○ (+) Sct, enterocyte purine metabolism gene (Enpp3, Ada, Nt5e, Slc28a2), Ido1 (goblet cell gene), immuno suppressive genes

○ (-) Il18

○ 1-2. villus tip in human

○ (+) MHC-I (HLA-A, HLA-B), MHC-II (HLA-DRA, HLA-DRB1, CD74), IL18, pro-inflammatory macrophage genes (C1QC, NLRP3, ADAMDEC1)

⑬ 영역 2. mid-villus region

○ (+) PPARD, HNF1B, TG resynthesis enzyme (MOGAT2, MOGAT3, DGAT1)

⑭ 영역 3. villus bottom

○ (+) GSTA2, most classic tuft cell marker (TRPM5, IL17RB, PLCG2, SH2D6, LY6H), SLC11A2 (iron import), AQP1, SCTR, IL11RA, antimicrobial proteins (REG3B, REG3G), TMEM159, BSCL2

⑮ 영역 4. crypt

○ (+) MYC, HES1, TFRC (iron import), AQP1, SCTR, IL11RA, defense response (REG3A, DMBT1), TMEM159, BSCL2, BMP4, BMP-inhibiting molecules (GREM1, GREM2), WNT ligands (WNT2, WNT2B, WNT10A/B)

○ 4-1. crypt in mouse

○ (+) Sst, Chgb

⑾ kidney epithelial cell

① (+) NAT8, AC093326.1, SLC13A1, MIOX, TMEM27, GLYAT, PDZK1, TINAG, BBOX1, AC009014.3 (Tabula Sapiens)

② 종류 1. loop of Henle cell

○ (+) UMOD, AQP1, IRX1, IRX2, IRX3, MECOM, POU3F3, TBC1D4, SLC12A1, DEFB1, GEM, RGS5, CYP4B1, DRAM1, NEK6, CDKN1C, CALCRL, CLCNKA, CRYAB, SPP1, PPP1R1B, LRRC66, IGF1, CLDN1, CLDN10 (sc-type)

○ (+) CXCL1, GEM, THBS1, PTGS2 (PanglaoDB)

○ 1-1. loop of Henle ascending limb epithelial cell

○ (+) Slc12a1, Umod, Egf, Wfdc15b, Gpx6, Nccrp1, Clcnka, Ppp1r1a, Kng2, Cldn19 (Tabula Muris)

○ 1-1-1. loop of Henle thick ascending limb epithelial cell

○ (+) KNG1, FXYD2, UMOD, LOC109729779, ATP1B1, ATP1A1, LOC105865250, SLC12A1, DNASE1, LDHB (Tabula Microcebus)

○ 1-1-2. loop of Henle thin ascending limb epithelial cell

○ (+) SPP1, FXYD2, WFDC2, ZC3H10, KNG1, UMOD, CTSD, S100A6, RPS18, TMEM176B, (Tabula Microcebus)

○ 1-2. loop of Henle descending limb epithelial cell

○ 1-2-1. loop of Henle thick descending limb epithelial cell

○ 1-2-2. loop of Henle thin descending limb epithelial cell

○ (+) SPP1, CLU, ZC3H10, PTGDS, FXYD2, RPS18, AQP1, RPL26, CTSD, S100A6 (Tabula Microcebus)

③ 종류 2. collecting duct cell

○ (+) Slc12a3, Rhcg, Calb1, Spink8, Pgam2, Uroc1, D630042F21Rik, Hsd11b2, Slc26a4, Emx1 (Tabula Muris)

○ 2-1. α-intercalated cell

○ (+) ATP6V1G3, ATP6AP2, RHBG, ATP1B1, LOC109729779, RHCG, LOC105879013, FOXI1, AQP6, AU129_gr01 (Tabula Microcebus)

○ (+) FOXI1, OXGR1, ATP6V1G3, AQP6, CA2, NR1I4, SLC4A1, RHCG, ATP6V1B1, AVPR1A, P2RY14, FXYD2, TMEM213, CA2, DMRT2 (sc-type)

○ 2-2. β-intercalated cell

○ (+) FOXI1, OXGR1, ATP6V1G3, SLC26A4, CA2, NR1I4, RHCG, ATP6V1B1, AVPR1A, INSRR, FXYD2, TMEM213, CA2, AP1S3 (sc-type)

○ 2-3. principal cells

○ (+) KCNE1, APELA, AQP2, AQP3, GATA3, ELF5, STC1, TBX3, CLDN4, KCNJ1, AVPR2, FXYD4, HSD11B2, SCNN1G (sc-type)

○ 2-4. inner Medullary cell

○ (+) S100A4, PLEKHB1, ALDH1A3, TM6SF1, SLC14A2 (sc-type)

④ 종류 3. renal tubular cell

○ (+) Dach1, Calb1

○ 3-1. renal distal tubule cell

○ (+) KLK1, KCNJ1, KL, EGF, TMEM213, TMEM52B, SOSTDC1, SLC12A3, EMX1, CLDN3, CLDN8, UMOD, PCOLCE, CDC42EP3, CLCNKB, FXYD2, POU3F3 (sc-type)

○ 3-2. renal proximal tubular cell

○ (+) 0610005C13Rik

○ (+) FXYD2, ATP1B1, SLC3A1, CUBN, PDZK1, LRP2, POU3F3, AGXT2, GSTA2, CYP2E1, CRYL1, GLYAT, SORD, UPB1, SOD3, HNF4A, CDKN3, NAPSA, SLC7A13, SLC17A3, HGD (sc-type)

○ (+) DPP4, ENPEP, LRP2, PDZK1, SLC34A1, ASS1, PCK1, SLC4A4, GLYAT, FBP1, FOLR1, AK4, SLC5A8, FAH, CRYL1, SLC13A1, TMEM27, APOE, HGD, SERPINF2 (PanglaoDB)

○ 3-2-1. kidney proximal straight tubule epithelial cell

○ (+) Spink3, Slc34a1, Slc39a5, Miox, Slc13a1, Rdh16, Ugt2a3, Lrrc19, Pck1, Slc22a8 (Tabula Muris)

○ (+) ALDOB, FXYD2, GPX3, MIOX, SMIM24, APOC3, LOC105867418, SPP1, AQP1, AU129_gr01 (Tabula Microcebus)

○ 3-2-2. kidney proximal convoluted tubule epithelial cell

○ (+) GPX3, ALDOB, FXYD2, MIOX, APOC3, LOC105866477, SMIM24, AU129_gr01, SLC34A1, LOC105867418 (Tabula Microcebus)

○ 3-3. connecting tubule cell

○ (+) CALB1, TRPV5, FXYD2, ATP6V1B1, SLC8A1 (sc-type)

⑤ 종류 4. ureteric bud cell

○ (+) GFRA1, RET, WNT9B, CLDN6, LAMA1, NMU, Wnt11, Etv4, WNT7B (sc-type)

⑥ 종류 5. conjunctival epithelial cell

○ (+) AQP5, POLR2J3, FAM83A, PAX6, GJB4, SYT8, SOX15, FGFBP1, SERPINB2, FAM110C (Tabula Sapiens)

⑿ lung epithelium

① 종류 1. airway epithelial cell

○ (+) ADH7, AQP1, CDH1, SEC14L3 (sc-type)

② 종류 2. epithelial cell

○ (+) ANPEP, EPCAM, IL10, IL6R (sc-type)

③ 종류 3. alveolar epithelial cell

○ (+) T1a, AQP5

④ 종류 4. bronchial epithelial cell

○ (+) MUC5AC

⑤ 종류 5. type i pneumocyte (alveolar type i, AT1)

○ (+) GPRC5A, AGER, RTKN2

○ (+) AGER, AKAP5, AQP3, AQP5, CCN2, CLDN18, CLIC5, COL4A3, COL4A4, CRLF1, CYP4B1, EGFL6, EMP2, FSTL3, GPRC5A, HOPX, ICAM1, IGFBP6, KRT7, MEX3B, MMP11, P2RX7, PDPN, PXDC1, RTKN2, SCNN1A, SCNN1B, SCNN1G, SEC14L3, SEMA3B, SEMA3E, SMARCA1, VEGFA (sc-type)

○ (+) AGER, GGTLC1, MS4A15, CEACAM6, ANKRD29, AQP4, C4BPA, KAL1, ATP13A4, ARHGEF26 (Tabula Sapiens)

⑥ 종류 6. type ii pneumocyte (alveolar type ii, AT2)

○ (+) SFTPB, SFTPC, MUC1, SLC34A2, Foxp2, Nkx2-1, Tmem213, LYZ, ALPL

○ (+) GKN2, SFTPA1, SFTPA2, SLC22A31, SFTPC, SFTPD, ROS1, NAPSA, ABCA3, CACNA2D2 (Tabula Sapiens)

○ (+) SFTPC, LOC105870139, LOC105873688, LOC105883485, SFTPB, TMSB4X, LOC105879971, SFTPD, CTSH, CXCL17 (Tabula Microcebus)

○ (+) ABCA3, ADGRF5, AGER, CD36, CD3G, CEBPA, CLDN18, CRLF1, CTNND1, CXCL2, CXCR2, DDX3Y, EGFL6, ETV5, GRK2, IL1B, INMT, IRX1, LAMP3, LPCAT1, LRG1, MUC1, NAPSA, NKX2-1, NRN1, PGC, PIGR, PPBP, PPP1R14C, RUNX3, S100G, SDC1, SFTA2, SFTPA1, SFTPB, SFTPC, SFTPD, SLC34A2, SOAT1 (sc-type)

○ (+) NKX2-1, MUC1, CLDN18, LAMP3, lSFTA2, SFTPD, SLC34A2, SFTPB, SFTPA1, SFTPC, ADGRF5, LPCAT1, NAPSA, ABCA3, PGC, CXCL2, PIGR (PanglaoDB)

⑦ 종류 7. cycling epithelial cell

⑧ 종류 8. ECM-high epithelial cell

⑨ 종류 9. tuft-like

⑩ 종류 10. club cell

○ (+) Scgb3a2, S100a6, Aqp5

○ (+) CYP2B7P, FOLR1, NEDD4L, KIAA1244, SCGB3A1, AGR3, OCLN, SHROOM3, ERBB2, CXCL17 (Tabula Sapiens)

○ 10-1. airway club cell

⑪ 종류 11. trachea double-positive, alpha-beta thymocyte

⑫ 종류 12. mesothelial cell

○ (+) C2, CALB2, CD44, CDH1, DES, EFEMP1, EPCAM, GSTA3, KRT5, KRT7, KRT72, LGALS7, LRRN4, ME1, ME2, MSLN, MUC16, OSR1, RSPO1, THBD, UPK3B, WT1 (sc-type)

⑬ 종류 13. tracheal goblet cell

○ (+) MUC5AC, RP11-412H8.2, BPIFA1, BPIFB1, MUC5B, ATP12A, CXCL17, AGR2, VMO1, LCN2 (Tabula Sapiens)

⒀ myoepithelial cell

① (+) KRT1

② (+) FBXO2, MYLK, ACTG2, SYNM, TFAP2C, KCNMB1, FAT1, SAA1, MIR143HG, KRT17 (Tabula Sapiens)

③ 종류 1. breast myoepithelial cell

○ (+) ACTG2, C6orf132, DSP, DST, GLIPR1, KARS, KLF5, KRT5, KRT6B, MYLK, NARS, OXTR, PTN, TRAF4, TUBB2B

⒁ neuroepithelial cell

① (+) NES, SOX2, NOTCH1, HES1, HES3, CDH1, OCLN, SOX10 (sc-type)

⒂ pancreatic epithelium

① 종류 1. cancer stem cell

○ (+) CD24, CD44, FLOT2

② 종류 2. pancreatic ductal cell

○ (+) CFTR, HNF1B, KRT20, MUC1, ONECUT1, AMBP, HHEX, ANXA4, SPP1, PDX1, CFB, GDF15, AKR1C3, MMP7, DEFB1, SERPING1, TSPAN8, CLDN10, SLPI, SERPINA5, PIGR, CLDN1, LGALS4, PERP, PDLIM3, WFDC2, AQP1, ALDH1A3, KRT19, TFF1, TFF2 (sc-type)

○ (+) SLC4A4, CFTR, CLDN10, RP11-528G1.2, SCTR, PKHD1, SFRP5, DCDC2, ANXA4, RP11-680F8.1 (Tabula Sapiens)

○ (+) GDF15, MMP7, SLPI, PERP, WFDC2, KRT19, KRT7, CLDN4, TACSTD2, CTSH, S100A10 (PanglaoDB)

⒃ prostate epithelium

① 종류 1. basal cell of prostate epithelium

○ (+) HCAR2, HCAR3, CYP4F8, RMST, HOXB8, SLC16A12, SPINK2, TNS4, GATA3-AS1, PIK3C2G (Tabula Sapiens)

② 종류 2. club cell of prostate epithelium

③ 종류 3. glandular cell

④ 종류 4. hillock cell of prostate epithelium

⑤ 종류 5. hillock-club cell of prostate epithelium

⑥ 종류 6. luminal cell of prostate epithelium

○ (+) KLK3, KLK2, ACPP, LINC01297, KLK4, NEFH, RP11-356O9.1, RPL7P16, RP11-388N2.1, NKX3-1 (Tabula Sapiens)

⒄ squamous epithelial cell

⒅ stomach epithelial cell

① 종류 1. ciliated epithelial cell

○ (+) CCDC37, C11orf88, FAM216B, LDLRAD1, TUBA4B, KIF19, DYDC2, ANKRD66, C9orf117, C10orf67, AC013264.2, LRRC71, CAPSL, TSPAN19, STOML3 (sc-type)

② 종류 2. squamous epithelial cell

○ (+) KRT6B, CAPNS2, KRT6C, FGFBP1, KRT6A, KRT17, ADH7, SERPINB10, KRT16, S100A3, CLCA2, LY6D, KRT4, AC019349.5, GPR87 (sc-type)

③ 종류 3. mesothelial cell

○ (+) RP11-74M11.2, AP000705.7, BNC1, SPHKAP, PTPRQ, NPHS1, TNNT1, TFPI2, BDNF, PDZRN4, LRP2, GFPT2, HAS1, WT1, COL8A1 (sc-type)

⒆ surface ectodermal cell

① (+) CCL21, RELN, MMRN1, PKHD1L1, ANGPT2, WFS1, SCN3B, SEMA3A, PIEZO2, PROX1 (Tabula Sapiens)

⒇ thymic epithelial cell

① (+) Tcrg-C1, Tbata

② (+) RP11-81F13.2, KCNJ5, RP11-153K16.1, RP11-81F13.1, LL22NC03-75H12.2, RP11-112J1.2, RP11-114G22.1, RP6-24A23.6, C11orf16, SLC46A2, CACNA1I, PTPRT, NPFFR2, RP1-223B1.1, C12orf56 (sc-type)

③ 종류 1. DN3 thymocyte

○ (+) TRBV25-1, TRAC, BCL11B, AP3M2, CD48, RPL22, TRBC2, RRN3P1, CD3D, TCF7 (Tabula Sapiens)

④ 종류 2. DN4 thymocyte

○ (+) CENPF, TOP2A, KIFC1, KIF14, CEP55, FAM72B, NUSAP1, UBE2C, KIF15, TPX2 (Tabula Sapiens)

⑤ 종류 3. double-positive, alpha-beta thymocyte

⑥ 종류 4. medullary thymic epithelial cell

○ (+) ITLN1, GALNT9, ITLN2, HP, UPK3B, MSLN, CFB, CALB2, PRG4, C1QL1

⒇ bladder epithelium

① 종류 1. bladder cell

○ (+) Asz1, Tgm5, Car3, Cck, Pitx1, Cntn4, Krtdap, Prss35, Hoxa11, Cpz (Tabula Muris)

② 종류 2. bladder urothelial cell

○ (+) DHRS2, BTBD16, UPK1A, TRIM31, PADI3, ATP1A4, PSCA, APOL1, VSIG2, UPK3A (Tabula Sapiens)

○ (+) Krt39, Muc15, Sprr2b, Ugt2b35, Gpa33, Upk1a, Sprr1a, Ivl, Gjb6, 1110032A04Rik (Tabula Muris)

○ (+) ZC3H10, RPS27, RPS18, RPLP1, RPS28, S100A6, RPL37, LOC105857397, RPL36, RPL37A (Tabula Miceocebus)

⒇ uterus epithelium

① 종류 1. epithelial cell of uterus

○ (+) LINC01541, ASRGL1, UCA1, SCGB2A1, PAEP, STX18, SEMA3B, DLX5, PAPSS1, ITGB8 (Tabula Sapiens)

⒇ mesothelial cell

① (+) SERTM1, SYT4, ITLN1, GALNT9, MGAT4C, UPK3B, PTPRQ", RP11-826N14.4, TMTC2 (Tabula Sapiens)

② (+) INS, REG3G, RPS18, S100A6, ZC3H10, TMSB4X, LOC105875474, RPS27, PRSS2, S100A4 (Tabula Microcebus)

③ (+) CALB2, MUC16, KRT5, KRT7, MSLN, WT1, PKHD1L1, SULF1, MIR22HG, COBLL1, GBP2, MEDAG, CRLS1, EFEMP1, RSPO1, RARRES2 (PanglaoDB)

④ 종류 1. lung mesothelial cell

○ (+) C2, CALB2, CD44, CDH1, DES, EFEMP1, EPCAM, GSTA3, KRT5, KRT7, KRT72, LGALS7, LRRN4, ME1, ME2, MSLN, MUC16, OSR1, RSPO1, THBD, UPK3B, WT1 (sc-type)

⑤ 종류 2. intestine mesothelial cell

○ (+) AP000705.7, HAS1, TNNT1, BNC1, DSC3, WT1, WNT10A, C21orf62, PTPRQ, CEMP1, C3, CRB2, KLK11, PHYHIP, TGM1 (sc-type)

⑥ 종류 3. spleen mesothelial cell

○ (+) QRFPR, SLPI, LHX9, PLA2G2A, CGN, NPHS1, KRT5, LRRN4, KLK11, OLR1, PTPRQ, COL8A1, PDZK1IP1, HAS1, SFRP2 (sc-type)

⑦ 종류 4. stomach mesothelial cell

○ (+) RP11-74M11.2, AP000705.7, BNC1, SPHKAP,P TPRQ, NPHS1, TNNT1, TFPI2, BDNF, PDZRN4, LRP2, GFPT2, HAS1, WT1, COL8A1 (sc-type)

⒇ tongue epithelium

① 종류 1. taste receptor cell

② 종류 2. salivary mucuous cell

○ (+) KRT14, THBS1, KRT17 (PanglaoDB)

③ 종류 3. acinar cell of salivary gland

○ (+) BPIFA2, LPO, PRB2, CA6, PRB1, MUCL1, PRH1, PRB4, PRH2, HTN1 (Tabula Sapiens)

⒇ olfactory epithelial cell

⒇ skin epithelium

① 종류 1. 각질형성세포(keratinocyte) : keratin-producing cell

○ (+) KRT4, IGFL1, LGALS7, SPINK5, RHCG, GBP6, IVL, CYSRT1, THEM5, SULT2B1 (Tabula Sapiens)

○ (+) CALML5, CD24, KRT5, KRT14, KRT17, AQP3, KRT15, S100A14, SFN, KRT10 (PanglaoDB)

○ 1-1. spinous cell (prickle cell)

○ (+) Krt1, Krt10

○ 1-2. basal cell

○ (+) Krt14, Krt5

○ 1-3. proliferating basal cell

○ (+) Mki67, Krt14, Krt5

② 종류 2. melanocyte

③ 종류 3. merkel cell

④ 종류 4. sebocyte(sebaceous gland, 피지세포)

○ (+) Mgst1, Scd1

⑤ 종류 5. trichocyte

⑥ 종류 6. hair follicle (HF)

○ 6-1. hair follicle associated cell

○ (+) Krt15, Krt17, Krt79

○ 6-2. HFSC (hair follicle stem cell)

○ (+) Lgr5, Cd34

○ 6-3. 모누두부(infundibulum)

⑦ 영역 1. epidermis

○ (+) Krt5, Krt14

⑧ 영역 2. dermis

○ (-) Krt5, Krt14

3. 유형 2. endothelial cell (내피세포) [목차]

⑴ 개요 : pan-endothelial cell (모든 내피세포)

① (+) CD31(PECAM1), CD34, VWF, PLVAP, CDH5, TIE-2, Axin2, WARS, AQP1, TIFA, Cyyr1, Hspa1b, NCOA7, DUSP23

② (+) PECAM1, CD34, KDR, CDH5, PROM1, PDPN, TEK, FLT1, VCAM1, PTPRC, VWF, ENG, MCAM, ICAM1, FLT4, SELE (sc-type)

③ (+) TM4SF18, PLVAP, WWTR1, MKL2, SOX18, CD320, S1PR1, NOTCH4, RAPGEF5, LIMS2 (Tabula Sapiens)

④ (+) Tlx1, Gm694, C1qtnf9, Kcna5, Rbp7, Fabp4, Aqp7, Glycam1, Apold1, Sele (Tabula Muris)

⑤ (+) PECAM1, VWF, CLEC14A, EMP1, RNASE1, CTGF, HYAL2, CALCRL, EMCN, ADGRL4, CLDN5, ECSCR, CDH5, TGFBR2, ENG, EGFL7, FLT1, EPAS1, CD34, SRGN, S100A10, IGFBP7, SPARC, SLC9A3R2, MGP, SPARCL1, TM4SF1, ID1, CD9, ID3, CAV1, GNG11, S100A13,IFI27, PCAT19, TIMP3 (PanglaoDB)

⑥ (+) CLDN5, TIE1, VWF, KDR, ROBO4, EMCN, MYCT1, HYAL2, TEK, ACVRL1, FLT4, MMRN2, ANGPT2, ARHGEF15, CD93 (SCEVAN)

⑵ adrenal vascular endothelial cell

① (+) CCL23, FGF23, SMIM9, RP13-1016M1.2, RP11-100L22.1, RP11-327L3.3, RP1-149A16.12, GPR182, DLL4, GALNT15, CALCRL, CD300LG, FLT4, FCN3, GPIHBP1 (sc-type)

⑶ angiogenic endothelial cells

① (+) CD105, VEGFR2, KIT, NRP2, COL15A1, PCDH17, ITGA6

⑷ pericyte : endothelial cell을 감싸는 fibroblast-like cell

① (+) Rgs5, Abcc9, NG2

② (+) GUCY1A2, COX4I2, NDUFA4L2, RGS5, NOTCH3, GJA4, GUCY1B3, FHL5, STEAP4, C2orf40 (Tabula Sapiens)

③ (+) PDGFRB, NOTCH3, COX4I2, HIGD1B, MCAM, NDUFA4L2, VIM, MFGE8 (PanglaoDB)

⑸ 조직 1. cardiovascular system

① 종류 1. artery endothelial cell

② 종류 2. capillary aerocyte(기체세포)

③ 종류 3. capillary endothelial cell

○ (+) FCN3, CA4, GPIHBP1, CD300LG, CDH5, PODXL, ROBO4, EMCN, BTNL9, HYAL2 (Tabula Sapiens)

○ (+) LOC105857591, B2M, LOC105855951, RAMP2, CD74, LOC105867540, MFGE8, CALCRL, RAMP1, LOC105856764 (Tabula Microcebus)

④ 종류 4. cardiac endothelial cell

○ (+) H19, CLIC5, F8, SLC14A1, TNNT3, MCF2L, KANK3, TMEM88, TCF15, TSPAN18 (Tabula Sapiens)

⑤ 종류 5. endothelial cell of artery

○ (+) IGFBP3, SEMA3G, MECOM, HEY1, CLEC14A, KIAA1462, JAM2, EFNB2, PIK3R3, SHE (Tabula Sapiens)

⑥ 종류 6. endothelial cell of vascular tree

○ (+) SELE, IL6, RND1, CNKSR3, STC1, SELP, ACKR1, SOX7, ADAMTS9, OLFM1 (Tabula Sapiens)

⑦ 종류 7. vein endothelial cell

○ (+) CCL14, OLFM1, ACKR1, DOC2B, PLVAP, FAM110D, RAMP3, SELP, LPCAT4, SLCO2A1 (Tabula Sapiens)

○ (+) TMSB4X, ZC3H10, ACKR1, RPS18, LOC105857591, ADIRF, SELE, B2M, RPS12, RPL37A (Tabula Microcebus)

⑧ 종류 8. endothelial cell of lymphatic vessel

○ (+) LYVE1

○ (+) MMRN1, CCL21, PKHD1L1, PROX1, FLT4, SMAD1, TFF3, NR2F1, RHOJ, LAYN (Tabula Sapiens)

○ (+) CCL21, B2M, ADIRF, VIM, RAMP2, TMEM176B, PLAC9, MMRN1, TIMP3, LOC105855951 (Tabula Microcebus)

⑨ 종류 9. lymphatic endothelial cell of heart

○ (+) GPR182, GPR97, STAB2, HOXD9, TBX1, CCL21, HOXD10, TSPEAR, ABCA4, PGM5-AS1, TFF3, LINC00636, RP11-341G23.4, HOXD4, RP11-451M19.3 (sc-type)

⑩ 종류 10. vascular endothelial cell of heart

○ (+) ESM1, SLC9C1, OPN5, QRFPR, MIR4454, AC007743.1, PKD1L1, TM4SF18, APLNR, CLRN1-AS1, CD300LG, C1QTNF9, AC019100.3, MADCAM1, RP11-298O21.5 (sc-type)

⑪ 종류 11. blood vessel endothelial cell

○ (+) EPHX4, POSTN, CCL14, TMEM255B, LCN6, CYTL1, NOS3, ACKR1, RILPL1, HSPA12B (Tabula Sapiens)

○ 영역 1. tunica intima

○ 영역 2. tunica media

○ 영역 3. tunica adventitia

⑫ 종류 12. vasa recta ascending limb cell

○ (+) LOC105855951, B2M, HYAL4, LOC105869179, LOC105871594, LOC105870764, LOC105870765, S100A6, RAMP2, CD74 (Tabula Microcebus)

⑬ 종류 13. vasa recta descending limb cell

○ (+) S100A6, AQP1, TIMP3, S100A4, TMSB4X, LOC105855951, HSPB1, MGP, B2M, JUN (Tabula Microcebus)

⑹ 조직 2. digestive system

① 종류 1. endothelial cell of hepatic sinusoid

○ (+) OIT3, CRHBP, CLEC4G, IL33, INSR, DNASE1L3, HECW2, BMPER, FAM167B, NTN4 (Tabula Sapiens)

② 종류 2. gut endothelial cell

○ (+) PCAT19, GPR126, FOXC1, JAM2, NRN1, CLDN5, SLCO2A1, THBD, PTPRB, ICAM1 (Tabula Sapiens)

③ 종류 3. liver endothelial cell

○ (+) FLT1, APPBP2, ARGLU1, ATP10D, BNIP1, BST2, BTNL9, C11orf96, CCDC85B, CCL14, CD4, CDC73, CDKL1, CHD4, CLEC1B, CLEC2B, CLEC4G, CLEC4M, CRBN, CRHBP, CTSL, DCLRE1C, DIPK2A, DLC1, DLG1, DLK1, DNASE1L3, DOCK1, DUSP5, EFNB2, ENG, F8, FCN2, FCN3, FILIP1, FOSB, FXYD6, GBP4, GGA2, GNG11, HES1, HYI, IL1R1, IL33, KDR, KIF1B, KLHL28, LDB2, MCAM, MCM3AP, MEF2C, MFN1, MGAT5, MPZL3, MRC1, OIT3, PIK3C2A, PPWD1, PTPRC, RASGEF1B, RASGRP3, RELN, RIN2, SECISBP2L, STAB1, STRN3, TCF12, TEX264, TFRC, TRAPPC11, TSPAN7, USP48, VWF, ZNF286B, STAB2, CD34, PECAM1 (sc-type)

④ 종류 4. vascular endothelial cell of intestine

○ (+) SOX17, GPIHBP1, PRND, CLEC3B, FLT1, MMRN2, BTNL9, APLNR, LHX6, NOTCH4, RP11-3K16.2, ESAM, RP11-328D5.1, ESM1, GJA5 (sc-type)

⑤ 종류 5. lymphatic endothelial cell of intestine

○ (+) RP11-474N8.5, TBX1, STAB2, CCL21, LINC00636, TSPEAR, ART5, CTC-236F12.4, GPR1, RP11-322E11.5, MPP7, Y_RNA, ABCA4, PLIN5, TP63 (sc-type)

⑥ 종류 6. vascular endothelial cell of stomach

○ (+) SELE, PRND, APLNR, ARHGEF15, PLVAP, FLT1, PCDH12, MADCAM1, GPIHBP1, GALNT15, RP4-601K24.1, MEOX1, A2M, CCM2L, CLEC14A (sc-type)

⑦ 종류 7. lymphatic endothelial cell of stomach

○ (+) NTS, STAB2, CCL21, RADIL, RP11-444A22.1, TFPI, RP11-142C4.6, TNFAIP8L3, LY86-AS1, PTGS2, RP11-554D15.1, EFCC1, MMRN1, Y_RNA, NFATC1 (sc-type)

⑧ 종류 8. portal vein

○ (+) Adgrg6, Gja5

⑺ 조직 3. excretory system

① 종류 1. kidney endothelial cell

○ (+) F8, AU021092, Emcn, Fam167b, Rsad2, Plvap, Esm1, Cldn15, Bhlhe22, Ppap2a (Tabula Muris)

○ (+) TGFBR2, NOTCH4, ADGRL4, EMCN, ENG, PECAM1, PLAC8, PLVAP, TEK, KDR, VWF, MMRN1, CD93 (sc-type)

○ 1-1. renal vesicle cell

○ (+) NCAM1, EMX2, LHX1, BMP2, DKK1, DLL1, GREB1, PAPSS2, PCSK9, POU3F3, TMEM100, WT1 (sc-type)

② 종류 2. bladder endothelial cell

○ capillary endothelial cell

○ endothelial cell of lymphatic vessel

○ vein endothelial cell

⑻ 조직 4. muscle endothelial cell

① 종류 1. lymphatic endothelial cell

○ (+) NTS, TFF3, CCL21, STAB2, PTX3, PCLO, IL7, P4HA3,C 6orf141, PIK3C2G, ASGR2, ANKRD36BP2, NALCN, FAM26F, NHLRC1 (sc-type)

② 종류 2. vascular endothelial cell

○ (+) MIR4454, SLC5A4, AL118508.1, CA4, RP11-206M11.7, PRSS51, NOS3, GRIN2A, GFRAL, CD300LG, MADCAM1, RP11-327L3.3, C1QTNF9, ANO2, AP001597.1 (sc-type)

⑼ 조직 5. nerve system

① 종류 1. retinal blood vessel endothelial cell

○ (+) LCN1, LACRT, SELP, ELOVL7, SELE, SYT15, MYRIP, CXorf36, THSD7A, CD200 (Tabula Sapiens)

② 종류 2. eye endothelial cell

○ (+) PECAM1, VWF, CDH5, BMP2, BMP4, CD34, CD55, FLT1, MED1, TGFBR1, TMEM98, TNFSF12, CD93, SLCO1A4, CLDN5, ICAM1, GNG11 (sc-type)

③ 종류 3. brain endothelial cell

○ (+) PECAM1, VWF, A2M, APOLD1, FLT1, TM4SF1, CD34, MCAM, ENG, PTPRC, VCAM1, CDH5 (sc-type)

⑽ 조직 6. prostate endothelial cell

① (+) PECAM1, CD34, MCAM, CDH5, VWF, ENG, KDR, PDPN, SELE, A2M (sc-type)

⑾ 조직 7. respiratory system

① 종류 1. lung endothelial cell

○ (+) Cldn5, Hpgd, Rasgef1a, Tmem100, Lyve1, Adrb1, Clec14a, Prx, Ripply3, Sox11 (Tabula Muris)

○ (+) CD34, EGFL7, EMCN, ESAM, FLT1, KDR, MCAM, PECAM1, RAMP2, TEK, VWF (sc-type)

② 종류 2. bronchial vessel endothelial cell

③ 종류 3. arterial endothelial cell

④ 종류 4. capillary endothelial cell

⑤ 종류 5. inflamed endothelial cell

⑥ 종류 6. pulmonary venous endothelial cell

⑦ 종류 7. systemic venous endothelial cell

⑧ 종류 8. lung microvascular endothelial cell

○ (+) ACKR1, CPLX1, NRN1, CCL23, CCL14, OLFM1, HERC2P2, FAM110D, RAMP3, CLDN5

⑿ 조직 8. vascular endothelial cell of placenta

① (+) RP11-1028N23.4, RP11-297H3.3, AC007743.1, RP11-327L3.3, CD34, ARHGEF15, CXorf36, LRRC36, SOX7, RP11-328D5.1, NTS, CDRT1, LINC01049, ROBO4, HS3ST3A1 (sc-type)

⒀ 조직 9. vascular endothelial cell of spleen

① (+) RP11-189E14.5, ODF3L2, RP4-765C7.2, AC019100.3, RP11-172F10.1, CTD-2207L17.2, RP1-154K9.2, AC010084.1, SLC5A4, OR5G5P, HOXD3, SNTG1, EEF1A1P31, ADAMTSL1, MYRIP (sc-type)

⒁ 조직 10. vascular endothelial cell of thymus

① (+) ADAMTS9, PROX1, MET, AC011526.1, MEOX2, ANO2, CTD-3179P9.1, NOVA2, AOC3, CXorf36, GPR116, PODXL, NRN1, PTPRB, LINC00472 (sc-type)

⒂ 조직 11. tumor-associated endothelial cell (TEC)

① (+) CD144

⒃ 조직 12. lymphovascular

① (+) TFF3, CCL21, TFPI, FABP5, PROX1, RGS16, PPFIBP1, EPHB4, ITGA9, MMM1, PDE2A, IGF1, CD9, LYVE1, FLT4, MAF, NRP2

4. 유형 3. immune cell (면역세포) [목차]

⑴ 면역세포

① (+) LCP2, LSP1, FYB, PLEK, HCK, IL10RA, LILRB1, NCKAP1L, LAIR1, NCF2, CYBB, PTPRC, IL7R, LAPTM5, CD53 (SCEVAN)

② 상태 1. ISG (interferon-stimulated gene) expressing immune cell

○ (+) IFIT1, IFIT2, IFIT3, IFIT5, ISG15, CCL3, CCL4, CCL3L3, RSAD2, OASL, CXCL10, IFI15, ISG20 (sc-type)

⑵ 대분류 I. leucocyte(백혈구)

① (+) CD45

② (+) SPRR2D, S100A7, SPRR2E, TIPARP, RUNX3, CD3G, GLIPR1, GPR183, RGS1, SPRR2A (Tabula Sapiens)

③ 소분류 A. lymphoid cell (림프구)

○ (+) NK1.1, B220, CD4, CD8

○ (+) CCL5, TMSB10, RPS27, LOC105874071, RPL13A, RPLP1, IL32, RPS11, GZMA, RPS15A (Tabula Microcebus)

○ 상태 1. innate lymphoid cell

○ (+) TCF7, CD69, TAGAP, AREG, TRAC, PIK3IP1, IL7R, CXCR4 (Tabula Sapiens)

④ 소분류 B. myeloid cell (골수세포)

○ (+) CD68, CD14, CD11b, ITGAX (CD11c), ADGRE1, MHC-II, Ly6G, Ly6C, CD86, HLA-DRA, F4/80, CST3, LYZ, Lamp3

○ (+) GPR34, CCR1, HLA-DRB5, C3AR1, CD68, CSF1R, SLC1A3, CLEC7A, MAFB, SIGLEC10 (Tabula Sapiens)

⑶ A-1. B cell (B lymphocyte)

① pan-B cell

○ (+) CD19 (거의 B 셀에서만 발현), CD20 (MS4A1), CD79A, CD79B, BLK, PTPRC, CD24, CD40, CD72, CD220, APOBEC3A, PELI1, ANKRD28, C2orf42, CCPG1, CLECL1, DNAAF1, DUSP5, ERN1, FAM107B, ITM2C, LGALSL, RAB30, SLAMF1, TRIB1, VOPP1, TNFRSF5, CLEC2C, FCRL4, HAVCR1, CR2, IL35, LILRB1, SPN, TLR9, TNFRSF13C, TNFRSF17, XBP1, MME, Btla, LAT2, BASP1

○ (+) LINC01781, BLK, TNFRSF13B, CD19, VPREB3, LY9, GNG7, BANK1, MS4A1, LINC02397 (Tabula Sapiens)

○ (+) Ms4a1, Cd79a, Crisp3, Faim3, Cd79b, Fcer2a, Tnfrsf13c, Cr2, Bank1, Cd19 (Tabula Muris)

○ (+) CD74, RPS27, RPL12, RPS15A, RPS28, RPL37, LOC105855163, RPL23A, RPL27A, RPS11 (Tabula Microcebus)

○ (+) CD69, CD79A, CD79B, IGHM, HLA-DRA, LTB, MZB1, VPREB3, CXCR4, IGLC2, IGKC, BCL11A, CD74, CD52 (PanglaoDB)

○ (+) HLA-DOB, HLA-DQA1, MS4A1, CD79B, BLK, GNG7, SPIB, TCL1A, FCRLA, HVCN1, NCF1, BANK1, CD79A, CD19, VPREB3 (SCEVAN)

② 종류 1. pre-pro-B cell

○ (+) Cd19, Cd43, Cd45r, Cd127, BP-1, cµ, λ5

○ (-) Cd19, Cd2

③ 종류 2. pro-B cell

○ (+) CD19, CD20, CD34, CD38, CD45R, CD22

○ (+) CD27, IgD, CD24, PTPRC, PAX5, CD24, CD38, CD79A, DNTT, C10orf10, VPREB1, ARPP21, CD99, IGLL1, CD9, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, VPREB3, IGLL5 (sc-type)

○ 2-1. large-pro-B cell (mouse)

○ (+) Cd19, Cd43, Cd45r, Cd127, BP-1, HSA, λ5

○ (-) Cd2, Cd22, Cd117, cµ

④ 종류 3. pre-B cell

○ (+) CD19, CD20, CD38, CD40, CD45R, CD34, Pou2af1, Cd93, Elk3, Satb1, Tox

○ (+) CD19, CD27, IgD, CD24, PTPRC, PAX5, CD24, CD38, CD79A, NSMCE1, PCDH9, ACSM3, CCDC191, TCL1A, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, VPREB3, IGLL5 (sc-type)

○ 3-1. large-pre-B cell (mouse)

○ (+) Cd19, Cd45r, Cd127, BP-1, cµ

○ (-) Cd2

○ 3-2. small-pre-B cell (mouse)

○ (+) Cd2, Cd19, Cd127, B220, cµ

○ (-) Cd43, sµ

⑤ 종류 4. immature B cell

○ (+) CD19, CD20, CD40, CD45R, IgM, CD38, CD5, CD53

⑥ 종류 5. transitional B cell

○ (+) CD10, CD19, CD20, CD25, CD30

○ (-) CD27

○ 5-1. transitional 1 (T1) B cell

○ (+) B220, Cd19

○ (-) Cd23

○ 5-2. transitional 2 (T2) B cell

○ (+) Cd23, Cd93, B220, IgD

⑦ 종류 6. marginal zone B cell

○ (+) CD1, CD19, CD20, CD21, CD27, Notch2, Cd1d, Cd21, Cd93, HSA, CD1D

○ (-) Cd35

⑧ 종류 7. follicular B cell / B2 cell

○ (+) IgD, CD21, CD22, CD23, Cd19, Cd21, Cd35, Cd93

⑨ 종류 8. B1 cell

○ (+) Cd11b, CD19, CD20, CD27, CD43, CD70, IgM, CD5

○ (-) Cd23, CD38

○ 8-1. B1 precursor

○ (+) Cd19, Cd45ra

○ (-) B220

⑩ 종류 9. plasma B cell (형질세포)

○ (+) CD27, CD38, CD40 CD78, CD95, CD138, CD319, IL-6, CXCR4, IGHG3, IGKC, IGHM, IGHG2, IGKV4-1, IGLV3-1, IGHA1, IGHG1, JCHAIN, Cd19, Cd138, IGKC, BCMA, BCL2, BCL6, XBP1, FKBP2, SELM, SSR3, VIMP, SPCS3, ERLEC1

○ (+) CD27, IgD, CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, VPREB3, IGLL5 (sc-type)

○ (+) IGHG1, IGJ (JCHAIN), IGHG3, MZB1, TXNDC5, IGHG2, DERL3, IGLC2, IGHG4, IGLC3 (Tabula Sapiens)

○ (+) LOC109729893, LOC105882024, JCHAIN, LOC105877808, LOC105862709, MZB1, HERPUD1, B2M, RPLP1, RPS18 (Tabula Microcebus)

○ (+) SDC1, CD38, CD27, CYCS, CD74, TNFRSF17, CD79A, EAF2, GNG7, IGKC, MZB1, IGLC2, IGHG1, IGHG2, IGHG3, IGHGP, IGLC3, JCHAIN, IGHA1, IGHG4, IGHA2, SSR4 (PanglaoDB)

○ (-) CD20, CD79A, CD79B, BLNK, MS4A1, IgM, Cd21, Cd22, Cd23, IgD, IgM

○ (-) CD20, MS4A1 (sc-type)

⑪ 종류 10. memory B cell (기억세포)

○ (+) CD19, CD20, CD27, CD40, CD80, PDL-2, CXCR3, CXCR4, CXCR5, CXCR6, IgA, IgG, IgE, B220, MHC class II, BCL2, CD53, CD21, FAS

○ (+) CD19, CD27, IgD, CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, CD27, VPREB3, IGLL5 (sc-type)

○ (+) AIM2, ADAM28, TLR10, CD19, TNFRSF13B, CD22, P2RX5, RP5-887A10.1, SCIMP, MS4A1 (Tabula Sapiens)

○ (-) CD38, CD150

⑫ 종류 11. regulatory B cell (조절 B 세포)

○ (+) IgD, CD1, CD5, CD21, CD24, TLR4, IL-10, TGFβ

⑬ 종류 12. NF B cell

○ (+) B220, Cd2, Cd19, HSA, IgM

○ (-) Cd21, Cd23, Cd35

⑭ 종류 13. activated germinal B cell

○ (+) B220, MHC class II

⑮ 종류 14. Breg

○ (+) CD1D, CD27, CD5

⑯ 종류 15. mature B cell

○ (+) CD22, CD21

⑰ 상태 1. naïve B cell

○ (+) CD19, CD20, CD23, CD40, CD150, IgD, IgM, CD22, CD53, CD21

○ (+) CD19, IgD, CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, VPREB3, IGLL5 (sc-type)

○ (+) TCL1A, IGHD, LINC00926, FCRL1, STAG3, RP11-693J15.5, FCER2, PAX5, FAM129C, CD22 (tabual sapiens)

○ (+) BANK1, CD37, CD69, CD79A, CD79B, IGHD, IGHM, IGKC, LTB, MS4A1, SELL, TCL1A, VPREB3, FOXP1, CD52, HLA-DQB1, TNFRSF13C, LINC00926, BIRC3, CD74 (PanglaoDB)

○ (-) CD27

⑱ 상태 2. switched B cell

○ (+) CD27

○ (-) IgD

⑲ 상태 3. unswitched B cell

○ (+) CD27, IgD

⑳ 상태 4. activated B cell

○ (+) CD80, CD86, FAS

⑳ 상태 5. functional B cell

○ (+) CD27, CCR7, CD197

⑷ A-2. T cell (T lymphocyte)

① pan-T cell (모든 T 세포)

○ (+) CD2, CD3 (CD3D, CD3E, CD3G), KLRC1, TUBA4A, TENT5C, CD274, CYTIP, GPR183, RHOH, SMAP2, ICOS, LAG3, CD47, CCR10, CD58, ITGAE, ITGAL (LFA-1), PTGDR2, IL10, IL13, IL17A, IL2, IL21, IL22, IL25, IL26, IL5, IL9, IGFB1, FOXO4, FOXP1, TBX21, PTPRC (CD45)

○ (+) CD96, SYTL3, RORA, IL7R, CD7, CD2, LEPROTL1, CNOT6L, TRACRUNX3 (Tabula Sapiens)

○ (+) Lcn4, Il7r, Folr4, Cd3d, Tnfsf8, Ms4a4b, Cd3g, Cd40lg, Vipr1, Cxcr6 (Tabula Muris)

○ (+) CCL5, TMSB10, IL32, LOC105874071, GZMA, LOC105858493, LOC105881712, S100A4, NKG7, CRIP1 (Tabula Microcebus)

○ (+) CD3D, CD3G, CD3E, LTB, IL7R, TRBC1, TRBC2, CD7, TRAC, IL32, CXCR4, CD2, CLEC2D, S100A4, LCK, JUNB, CD52 (PanglaoDB)

○ (+) HLA-B, PTPRC, SH2D1A, CD3E, LCK, CD48, ACAP1, GIMAP7, SEPTIN1, CD69, LINC00861, CDC42SE2, CD96, TSTD1, GIMAP4 (SCEVAN)

② 종류 1. helper T cell (Th)

○ (+) CD4

○ (+) LEF1, TCF7, BCL11B, CAMK4, ITK, IPCEF1, INPP4B, CD6, SCML4, PRKCQ-AS1 (Tabula Sapiens)

○ (+) AC092580.4, OXNAD1, KLRB1, STAT4, CRIP1, SYTL3, PDE4D, RCAN3, CD3G, RORA (Tabula Sapiens)

○ (+) LOC105855976, IL32, RPS27, LOC105874071, IL21, CGA, LRRC31, FOXP3, LOC105873674, GABBR2 (Tabula Microcebus)

○ 1-1. Th1 (helper T cell 1, 세포 도움 T세포 1)

○ (+) CD4, CXCR3, IFNγ, IL-2, IL-12, IL-18, STAT4, STAT, TNF, T-Bet, IFNG, GZMB, Tbx21

○ (-) CD8A, CD8B, FOXP3, IL2RA

○ 1-2. Th2 (helper T cell 2, 세포 도움 T세포 2)

○ (+) CD4, CCR4, IL-2, IL-4, GATA-3, Gata3

○ (-) CD8A, CD8B, FOXP3, IL2RA

○ 1-3. Th9

○ (+) PU.1, IL-9

○ 1-4. Th17

○ (+) RORγt, IL-17, RORA, RORC, RBPJ, BHLHE40, CCR6, IL23R, Rorc

○ Th17 chemoattraction

○ (+) CXCL16, CCL20

○ 1-5. Th22

○ (+) AHR, IL-22

○ 1-6. Tfh (T follicular helper cell)

○ (+) BCL6, CXCR5, IL-21

○ (+) AL135905.2, CD28, CD5, PBX4, KCNA3, CD7, CCR7, CD6, LSR, RP4-765C7.2 (Tabula Sapiens)

○ 1-7. effector CD4+ T cell

○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) TCF7, LEF1, ITK, BCL11B, CITED2, CD3E, CAMK4, IL7R, CD69, SPOCK2 (Tabula Sapiens)

○ (-) SELL, CCR7 (sc-type)

○ 1-8. memory CD4+ T cell

○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD45RO, CD6, CTLA4, IL2RA, GZMB, SELL, CCR7, S100A4, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) TRAT1, TRAC, LCK, BCL11B, TCF7, ITK, PIK3IP1, SPOCK2, IL7R, CD3G (Tabula Sapiens)

○ 1-9. metallothionein-expressing T cell : metallothionein은 세포를 산화적 스트레스와 세포 독성으로부터 보호함

○ (+) MT1, MT2

○ 1-10. SRRM2-T cell

○ (+) PNISR, SRRM2

○ 1-11. naïve CD4+ T cell

○ (+) CCR7, LEF1

○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, SELL, CCR7, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) PRKCQ-AS1, CCR7, TXK, TRAC, NOSIP, LCK, TCF7, CCDC109B, BCL11B, PIK3IP1 (Tabula Sapiens)

○ (-) CD25, CD44, CD69, HLA-DRA, CD95 (sc-type)

③ 종류 2. cytotoxic T cell (Tc)

○ (+) CD8

○ (+) AC092580.4, CD8A, CD8B, CCL5, GZMA, KLRD1, SYTL3, CD2, CD3G, CD96 (Tabula Sapiens)

○ (+) CCL5, IL32, LOC105881712, LOC105874071, TMSB10, LOC105881288, GZMA, LOC105866296, NKG7, LOC105858493 (Tabula Microcebus)

○ (+) CD2, CD5, CD69, GZMB, TRAC (PanglaoDB)

○ 2-1. cytotoxic T cell (killer T cell, 세포 독성 T세포)

○ (+) IFNγ (IFNG), TNF, CD8, EOMES, CD8A, CD8B, Thy1.1, KLRG-1, GZMH, PRF1

○ (+) GZMK, CD8A, CD8B, MATK, DUSP5, GZMM, PTPRCAP, CTSW, ZAP70, DUSP2 (Tabula Sapiens)

○ (-) CD4

○ 2-2. CD8-positive effector t cell

○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, GNLY, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) GNLY, CEP78, KLRF1, NKG7, PTGDR, RP11-489E7.4, HIST1H1E, HIST1H1D, SAMD3, GZMM (Tabula Sapiens)

○ (+) GZMK, CD8B, CD8A, DUSP2, GZMM, CCL4, CMC1, CD3E, CCL5, CD69 (Tabula Sapiens)

○ (-) SELL, CCR7 (sc-type)

○ 2-3. memory CD8+ T cell

○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD45RO, CD6, CTLA4, IL2RA, GZMB, SELL, GNLY, S100A4, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) GZMK, SH2D1A, CD8A, CD8B, GZMM, DUSP2, CCL5, GZMA, CTSW, CMC1 (Tabula Sapiens)

○ 2-4. naïve CD8+ T cell

○ (+) CCR7

○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, SELL, GNLY, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) LYAR, FGFBP2, GZMH, MYBL1, KLRD1, GZMA, CD8A, CCL5, KLRG1, GNLY (Tabula Sapiens)

○ (-) CD25, CD44, CD69, HLA-DRA, CD95 (sc-type)

④ 종류 3. Treg cell (regulatory T cell, 조절 T 세포)

○ (+) CD4, CD25, CD127, CD152, TGFβ, IL-10, IL-12, FOXP3 (FoxP3), STAT5, IL2RA, CTLA4, TIGIT, IL1RL1, ICOS, TNFRSF9

○ (+) FOXP3, RTKN2, TIGIT, CTLA4, IL2RA, IKZF2, BATF, TRBV25-1, SPOCK2, CD28 (Tabula Sapiens)

○ (-) CD8A, CD8B

○ 3-1. naïve regulatory t cell

○ (+) TIGIT, CTLA4, CD5, ABCC1, PTPRCAP, ITK, SPOCK2, IKZF2, LEF1, RP4-765C7.2 (Tabula Sapiens)

⑤ 종류 4. gamma delta T cell (Tgd cell, γδ-T cell) : 일반적인 셀 타입인 alpha beta T cell과 비교됨. innate-like T cell 중 하나

○ (+) CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, TRDV2, TRGV9, TRGC1, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)

○ (+) GNLY, GZMB, FGFBP2, NKG7, PRF1, KLRF1, HOPX, CST7, KLRD1, CTSW, SPON2, GZMA, CD247, CD7, CCL5, TRDC (PanglaoDB)

○ (-) SELL, CCR7 (sc-type)

⑥ 종류 5. pro-T cell

○ 5-1. DN1 thymic pro-T cell

○ (+) GZMK, CCL4, SOCS1, PRDM1, TRBV25-1, CD2, KLRB1, CCL5, IL7R, TRAC (Tabula Sapiens)

⑦ 종류 6. DN T(double-negative T cell)

⑧ 종류 7. MAIT(mucosal-associated invariant T cell) : innate-like T cell 중 하나

○ (+) SLC4A10

⑨ 상태 1. activated T cell

○ (+) CD69, CD25

○ 1-1. early activation

○ (+) GZMK, GZMM, GZMA, NKG7

⑩ 상태 2. cytotoxic

○ (+) granzyme, perforin

⑪ 상태 3. naïve

○ (+) CD45RA, CD62L, CCR7, LEF1, SELL, TCF7, IL7R

○ (+) CD3D, SELL, CCR7 (PanglaoDB)

⑫ 상태 4. memory

○ (+) SELL, CD69, CD247, IL7R, CD3E, GIMAP4, CD2, PTPRC, TCF7, LTB, LCK, TRAC, CD3G, CD3D, TRBC2, CD7 (PanglaoDB)

○ 4-1. effector memory (EM)

○ (+) CD45, CD3, CD4, CD44, CD45RO

○ (-) CD62L, CCR7

○ 4-2. central memory (CM)

○ (+) CD45, CD3, CD4, CD44, CD62L, CD45RO, CD62L, CCR7

⑬ 상태 5. effector

○ (+) CD45RA

○ (-) CD62L, CCR7

⑭ 상태 6. experienced

○ (+) INPP5F, GPR25

⑮ 상태 7. progenitor exhausted

○ (+) TCF1/TCF7, PD-1, TIM-3

⑯ 상태 8. terminally exhausted

○ (+) Tox/Tox2, PDCD1 (PD-1), TIGIT, HAVCR2, LAG3, CTLA4, ENTPD1

⑰ 상태 9. immature

○ (+) Rag2, Arpp21, Rag1, A930003A15Rik, Dntt, Syt13, Capn3, Cd8a, Ccr9, Cd8b1 (Tabula Muris)

⑸ A-3. NKT cell (natural killer T-cell)

① (+) CD56, CD3

② 종류 1. type I NKT (iNKT)

○ (+) TCR, Va24, Vβ11

○ (+) CMC1, KLRB1, HIST1H1D, DUSP2, TXK, CD69, CD3E, CITED2, HIST1H1E, AREG (Tabula Sapiens)

③ 종류 2. type II NKT

④ 종류 3. mature NKT cell

○ (+) KLRF1, PRF1, FGFBP2, GNLY, IL2RB, GZMB, NKG7, SAMD3, CTSW, PYHIN1 (Tabula Sapiens)

○ (+) CCL5, IL32, LOC105874071, RPS27, RPL13A, GZMA, TMSB10, RPS11, LOC105881712, CST7 (Tabula Microcebus)

⑤ 종류 4. CD4+ NKT-like cell

○ (+) CD4, CD56, CD2, CD16, CD94, CD3D, CD3E, CD3G, CD3Z, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, COX6A2, ZMAT4, KIR2DL4 (sc-type)

⑥ 종류 5. CD8+ NKT cell

○ (+) CD8, CD56, CD2, CD16, CD94, CD3D, CD3E, CD3G, CD3Z, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, GNLY, COX6A2, ZMAT4, KIR2DL4 (sc-type)

⑹ A-4. natural killer cell (NK, 자연살상세포)

① pan-NK cell (일반적인 NK cell)

○ (+) NCAM1, NCAM2, FCGR3A, CD56, CD94, NKp46, KLRB1, KLRC1, KLRD1, KLRF1, KLRK1, NCR1, FCGR3B, KLRG-1, GNLY, CD244, PRF1, FCER1G, CD247, NK1.1, CCL3, SLAMF6, NCR2, TNFRSF18, LAG3, CD7, NCR3, KIR3DL1, XCL1, CD160

○ (+) Klra8, Gzma, Klra23, Ncr1, Klra18, Ccl5, Gzmb, Cma1, Klra9, Klre1 (Tabula Muris)

○ (+) CCL5, GZMA, LOC105874071, IL32, TMSB10, NKG7, LOC105881712, CST7, LOC105881899, LOC105855163 (Tabula Microcebus)

○ (+) CD56, CD2, CD16, CD94, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, FCGR3A, GNLY, COX6A2, ZMAT4, KIR2DL4 (sc-type)

○ (+) CD69, KLRD1, GNLY, NKG7, IL32, GZMH, CTSW, CCL4, CD2, CCL5, GZMA, GZMB, DUSP2, CST7, CXCR4, S100A4, IL2RG, HOPX (PanglaoDB)

○ (-) CD3D, CD3E, CD3G, CD3Z, CD4, CD8 (sc-type)

② 종류 1. PB mature NK cell

○ (+) CD16

○ (-) CD56

○ 1-1. cytotoxic

○ (+) Granzyme, Perforin

③ 종류 2. PB immature / regulatory NK cell

○ (+) CD56, NCR

○ (-) CD16

④ 종류 3. CD3-negative NK cell : 더 일반적

○ (-) CD3

⑤ 종류 4. CD3-positive NK cell

○ (+) CD3

⑥ 상태 1. activated

○ (+) CD69

⑦ 상태 2. immature

○ (+) SCN1B, SNORD3B-1, RUNX2, CIDEB, TMIGD2, STAC, TNFSF4, BCAS1, PCDH9, TSIX (Tabula Sapiens)

⑺ A-5. nuocyte

⑻ B-1. granulocyte (과립세포)

① pan-granulocyte

○ (+) CD203c, CD15, CD11b, CD63, CD66b, CD123, CD16, CD33, CD117, CD45, Fc-epsilon RI-alpha, CD125, CD13, CD14, CD25, CD44, CD69, CD9, HLA-DR, CCR3, CD116, CD11c, CD193, CD24, CD32, CD43, CXCL8, FCGR3B, MNDA, SIGLEC8, AZU1, MPO, CTSG, LYZ (sc-type)

○ (+) MPO, AZU1, PRTN3, ELANE, MS4A3, CLEC11A, RNASE3, MKI67, TOP2A, UHRF1 (Tabula Sapiens)

○ (+) S100a8, S100a9, Krt81, Ngp, Camp, Lcn2, 1100001G20Rik, Ceacam10, Mmp8, Retnlg (Tabula Muris)

② 종류 1. basophil (호염기구) : 과립이 분산된 형태

○ (+) MS4A2, FcεR1α, Hgf

○ (+) CD22, CD63, CD203c, CD123, CLC, MS4A3, TCN1, CPA3, HDC, GATA2, MS4A2, IL4, GCSAML, GATA2, TPSAB1 (sc-type)

○ (+) VWA5A, LTC4S, C1orf186, MS4A2, CPA3, TPSB2, HPGDS, TPSAB1, SLC18A2, KIT (Tabula Sapiens)

○ (-) CD19, CD45, CD117

○ 1-1. activated

○ (+) CD63, CD203c

③ 종류 2. eosinophil (호산구) : 과립이 2개의 덩어리 형성

○ (+) CD45, CD125, CD193, F4/80, Siglec-8, CD16

○ (+) CD11b, CD193, CD123, CD125, CD15, SIGLEC8, CLC, GATA1, CEBPE, SEMG1, ALOX15, CCL23, PRSS41, PRSS33, THBS4, FOXI1 (sc-type)

④ 종류 3. neutrophil (호중구) : 과립이 3개의 덩어리 형성

○ (+) CD11b, CD16, CD18, CD32, CD44, CD55, Ly6G, S100A8, S100A9, CSF3R, CD66b, CD15, SSEA1, NEAT1, CEACAM8

○ (+) CXCR1, CMTM2, MMP25, MGAM, CD177, PADI4, FCGR3B, MMP9, CXCR2, PROK2 (Tabula Sapiens)

○ (+) S100A12, S100A9, S100A8, CAMP, ACTB, LTF, TMSB4X, LCN2, RETN, PGLYRP1 (Tabula Microcebus)

○ (+) CD66b, CD11b, CD15, CD16, CXCL8, FCGR3B, MNDA, CXCR2, MPO, ELANE, PRTN3, MPO, AZU1, LYZ, S100A8, S100A9, PI3, CHI3L1, ANXA3, CXCL1, TGM3, BTNL3, C4BPA, MMP9, CD24, BPI, LTF, GCA, Camp, Ngp, Chil3, Ltf (sc-type)

○ (+) MPO, LYZ, ELANE, S100A8, PRTN3, AZU1, CTSG, SERPINB1, S100A4 (PanglaoDB)

○ 3-1. cd24 neutrophil

○ 3-2. nampt neutrophil

⑤ 종류 4. mast cell (비만세포)

○ (+) CD32, CD33, CD117, CD203c, FcεR1α, MS4A2, Tryptase, C5ar1

○ (+) CD117, CD203c, CD25, KIT, SLC18A2, CD33, CD32, FCER1A, TPSD1, HPGDS (sc-type)

○ (+) HDC, TPSAB1, TPSB2, CPA3, MS4A2, C1orf186, HPGDS, KIT, SLC18A2, VWA5A (Tabula Sapiens)

○ (+) KIT, CPA3, TPSAB1, IL1RL1, RGS1, HDC, TPSB2, RGS13, MS4A2, VWA5A, HPGDS, DUSP1 (PanglaoDB)

○ (+) CPA3, CMA1, CTSG, SIGLEC6, MS4A2, HDC, PRG2, SLC18A2, TAL1, TPSAB1, SIGLEC8, HPGDS, AMHR2, LAX1, NDST2 (SCEVAN)

○ 4-1. activated

○ (+) CD203c

⑥ 종류 5. granulocytopoietic cell

○ S100a8, S100a9, Camp, Ngp, Fcnb, Lcn2, Chi3l3, 1100001G20Rik, Cebpe, Ltf (Tabula Muris)

⑼ B-2. dendritic cyte (DC, 수지상세포)

① pan-dendritic cell

○ (+) IL3RA, CD1C, BATF3, THBD, CD209, CD11C, HLA-DR, CLEC4C, NRP1, FCER1A, CD14, ETV6, CD80, CD86, ADGRE5, IL2RG, LILRA4, CMRF-44, IFNa, BTLA, CADM1, ITGAE, LY75, CLEC4K, CD1B, ITGAM

○ (+) CD86, CPVL, HLA-DPB1, HLA-DPA1, HLA-DQB1, HLA-DMB, HLA-DMA, CXCL16, HLA-DRA, YWHAH (Tabula Sapiens)

○ (+) TMSB4X, CD74, LOC105869751, LOC105872012, CST3, LOC105876793, TMSB10, RPS27, IFI30, LOC105869753 (Tabula Microcebus)

○ (+) S100A9, HLA-DRA, HLA-DQA1, HLA-DMA, HLA-DQB1, HLA-DRB1, HLA-DPA1, HLA-DPB1, S100A4, CLEC7A, AIF1, LST1, CTSS, PTPRC, FTL, ANXA1, LGALS3, H2AFY, HLA-A, HLA-B, HLA-C (PanglaoDB)

② 종류 1. activated dendritic cell (aDC)

③ 종류 2. immature dendritic cell (iDC)

④ 종류 3. liver dendritic cell

○ (+) HLA-DRB5, SNRPGP14, HLA-DQA1, FCER1A, P2RY6, HLA-DQB1, S100B, RAB7B, CLEC10A, RP11-242C19.2 (Tabula Sapiens)

⑤ 종류 4. mature conventional dendritic cell

○ (+) IDO2, FSCN1, CCL22, GPR157, TVP23A, IDO1, WFDC21P, TBC1D8, LAMP3, EBI3 (Tabula Sapiens)

⑥ 종류 5. myeloid dendritic cell

○ (+) ITGAX, CD83, CD1C, NRP1, CLEC4C, CD86, IL3RA, CD80, CD1A, ITGAX, CD40, HLA-DQA1, CD11c, HLA-DR, HLA-DPB1, HLA-DPA1, CLEC10A, CST3, GPR31, ODF3L1, PRB2, CD207, ARSE, CLEC141, MRC, EBLN1, CRIP3 (sc-type)

○ 5-1. cd1c-positive myeloid dendritic cell

○ (+) MRPS6, C15orf48, KYNU, HLA-DQA2, VMO1, EPB41L3, IL4I1, TFRC, GK, AGPAT9 (Tabula Sapiens)

○ 5-2. cd141-positive myeloid dendritic cell

○ (+) LGALS2, WFDC21P, CPVL, C1orf54, EBI3, BATF3, CLIC2, ADRBK2, HLA-DQA1, FLT3 (Tabula Sapiens)

⑦ 종류 6. oligodendrocyte (희소돌기아교세포)

⑧ 종류 7. plasmacytoid dendritic cell (pDC) : rare한 DC 서브타입. blood에서의 면역작용에 관여하고 인터페론1을 과량 분비. IFN-α를 분비하여 T 세포를 활성화하지만, T 세포의 확장을 억제하기 위해 그란자임 B를 분비

○ (+) SIGLECH, KLK1, HLA-DR, IL3RA (CD123), IRF8, TCF4 (E2-2), SPI1 (PU.1), FLT3L

○ (+) ITGAX, CD83, CD1C, NRP1, CLEC4C (BDCA-2), CD86, IL3RA, CD80, CD1A, ITGAX, CD40, HLA-DQA1, CD11c, HLA-DR, HLA-DPB1, HLA-DPA1, CLEC10A, CST3, TPM2, LRRC26, ASIP, GPM6B, KRT5, NTM, SCT, SHD, KCNA5, SCARA5, EPHA2, MYMX (sc-type)

○ (+) IRF7, SLC15A4, PLD4, LAMP5, IRF4, RUNX2, GZMB, BCL11A, CHAF1A, ADA (Tabula Sapiens)

○ (+) LILRA4, GPR183, PTCRA, FAM129C, SPIB, GZMB, CXCR4, IRF7, IRF8, JCHAIN, SERPINF1, ITM2C, TCF4, BCL11A, MZB1, DERL3, NRP1 (PanglaoDB)

○ 7-1. activated

○ (+) CD83

⑨ 종류 8. conventional DC (cDC) : innate immune cell 중 하나

○ (+) CD11c, HLA-DR, LY75

○ 8-1. cDC1 (excel at cross-presentation)

○ (+) XCR1, CLEC9A

○ 8-2. cDC2

○ (+) CD1C, SIRPα, CLEC10A

○ 상태 1. activated

○ (+) CD83

⑩ 종류 9. functoinally defective DC

⑪ 종류 10. regulatory DC(regDC; tolerogenic DC; tDC)

○ (+) MHC II, CD11b, CD11c, PD-1, B7-H1

○ 10-1. CD83^highCCR7⁺ IL-10DC

○ 10-2. CD83^lowCCR7^- IL-10DC

○ 아직 뚜렷한 표면 발현 마커는 없음

⑫ 종류 11. langerhans-like DC (LanghDC)

⑬ 종류 12. migratory DC (migDC)

⑭ 종류 13. AXL+SIGLEC6+ DC (ASDC)

⑽ B-3. macrophage (대식세포)

① pan-macrophage

○ (+) CD11b, CD68, CD163, ADGRE1, ITGAM, CSF1R, CD14, FCGR3A, Cd74, Arg1, CD80, CD86, CXCL5, APOC1, BASP1, FAM49A, GJB2, LPXN, LY86, MAP3K8, MNDA, PLD4, PPARG, SEC24A, SERPINB9, IL1a, IFNb2, CDF, BSF1, BCGF1, TGIF, CSIF, IL13, P600, CSFR, CLEC13D, M130, PDL2, B7DC, RETNLB, CCR2, CSF1, CLEC6A, ITGB2, PDCD1LG2, CSF2, LYZ, PLAUR, LST1

○ (+) MARCO, ACP5, OLR1, PLTP, SLCO2B1, MS4A4A, C1QC, MSR1, FBP1, MRC1 (Tabula Sapiens)

○ (+) Cd300c, Siglech, Apol7c, Gm8221, H2-M2, Cox6a2, Lilra5, Atp2a1, Cd209g, Cd209f (Tabula Muris)

○ (+) FTL, FTH1, LOC105882215, CD74, TMSB4X, APOE, CST3, LOC105869751, C1QA, SPP1 (Tabula Microcebus)

○ (+) CD68, CD163, CD14, CD11b, CD206, CD80, CD86, CD16, CD64, CCL18, CD115, CD11c, CD32, HLA-DR, MRC1, MSR1, GCA, Pf4 (sc-type)

○ (+) ITGAM, FCGR3A, LILRB4, TREM2, CXCL16, CD83, RBPJ, GPNMB, VSIG4, MS4A4A, C5AR1, CCL2, S100A4, NRP2, CD36, MS4A7, CLEC7A, CD74, CSF1R, LGALS3, CYBB, ITGAX, TYROBP, DAB2, MAF, AIF1, CYP27A1, SLC7A7 (PanglaoDB)

○ (+) CD68, CD163, MS4A4A, CYBB, FCER1G, CLEC5A, MS4A6A, HK3, MSR1, IGSF6, CHIT1, DNASE2B, FDX1, SLAMF8, VSIG4 (SCEVAN)

○ (-) CD56, CD11c

② 종류 1. M1 대식세포

○ (+) iNOS, IL-6, CD86, CD80, CD68, MHCII, IL-1R, TLR2, TLR4, SOCS3, ITGAX (CD11c), CD16, FCN1, HLA-DR, pSTAT1, IL-12, MHC-II, CD80, 27E10, CCL2, S100A8, S100A9, CXCL9, CXCL10

③ 종류 2. M2 대식세포

○ (+) MRC1, CD163, CD204, CD206, VEGF, cMAF, ARG1, YM1, CCL20, CCL22, 1IDO1

○ 2-1. M2a

○ (+) CD163, SR, CD206, CD200R, TGM2, DecoyR, IL-1R II, Fizz1, Arginase-1, MHCII

○ 2-2. M2b

○ (+) CD86, MHCII

○ 2-3. M2c

○ (+) CD163, TLR1, TLR8

○ 2-4. M2d

○ (+) VEGF

○ 2-5. TAM

○ (+) CCL2, CD3, CD31, CD68, CD163, HLA-DR, iL-10, iNOS, PCNA, VEGF

○ 2-6. TCR-positive

○ (+) CD68, Fyn, LAT, Lck, ZAP70

○ 2-7. CD169-positive

○ (+) CD11b, CD11c, CD68, F4/80, MHCII

④ 분류 1. bone-marrow-derived macrophage (BMDM)

⑤ 분류 2. dust cell

⑥ 분류 3. Kupffer cell (쿠퍼 정상세포)

○ (+) CD14, CD68, TNF, LYZ, MPO, VSIG4, PROK2, STARD5, MSR1, PPARA, TREM1, SLC11A1, MMP13, VDR, CHIT1, OSM, PPARD, CLEC4F, ADGRE1, IL1B, SLC40A1, G6PD, TIMD4, MNDA, SLC15A3, DNASE1L3, MARCO, HFE, CD38, CD163, CCR5, CLEC1B, CLEC4G, GPIHBP1, FOLR2, PLTP, FTL, IRF7, SPIC, CSF1R, C1QC, C1QA, C1QB, CLEC4E (sc-type)

○ (+) CLEC4F, ID3, ZEB2, LXRα

⑦ 분류 4. microglial cell

○ (+) BHLHE41, SLC2A5, HAMP, FCGR1A, SLC1A3, AP1B1, B3GNT5, HAVCR2, LILRB4, CSF1R (Tabula Sapiens)

○ (+) NAIP, CX3CR1, P2RY12, CCR1, FGD2, FCGR2A, DOCK8, TREM2, FOLR2, ADAM28, C1QC, P2RY13, C1QA, CD68, C1QB (SCEVAN)

○ 4-1. eye microglial cell

○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1, CX3CR1, CX3CL1 (sc-type)

○ 4-2. brain microglial cell

○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1 (sc-type)

○ (+) IBA1, Cd68, TMEM19, P2RY12, SALL1

⑧ 분류 5. splenocyte

⑨ 분류 6. immunosuppressive macrophage

○ (+) CD163, MSR1

⑩ 분류 7 . TIM4+ perivascular macrophage

○ (+) TIM4, LYVE1, FOLR2, cMAF

○ (-) MHCII

⑪ 분류 8. MHCII+ Perivascular Macrophage

○ (+) MHCII, cMAF

○ (-) TIM4, LYVE1

⑫ 상태 1. aged macrophage

○ (+) Cd274, Clec4d

○ (-) Coro1a

⑾ B-4. monocyte (단핵구)

① (+) CD14, FCGR1A, CD68, S100A12, NR4A1, CD4, CD11C, HLA-DR, SPI1, NCF2

② (+) FOLR3, TCIRG1, RP11-1143G9.4, RNASE2, SULT1A1, FCN1, CD300E, PRAM1, ARHGAP4, C19orf38 (Tabula Sapiens)

③ (+) Lyz2, Lyz1, Galnt9, Ms4a8a, Apoc2, Gm9733, Ms4a6c, Ccr2, Ccl9, Ccl6 (Tabula Muris)

④ (+) FTH1, SOD2, TMSB4X, CCL15, LGALS1, CD74, S100A4, PGLYRP1, CXCL8, FTL (Tabula Microcebus)

⑤ (+) OAS1, IRF7, PLSCR1, MX1, HLA-DRA, IFIT1, IFIT3, TNFSF10, S100A9, S100A4, CD44, PTPRC, PSAP (PanglaoDB)

⑥ (-) CD206, CD86

⑦ 종류 1. classical monoctye (C monocyte)

○ (+) CD14, S100A8, S100A9

○ (+) CD14, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, VCAN, S100A12, CXCL8, S100A8, S100A9, LYZ, CST3, Elane1 (sc-type)

○ (+) FLT3, TMEM170B, IFI30, RNASE2, FCN1, ADAMTS2, EMILIN2, CD33, SH3BP2, SLC43A2 (Tabula Sapiens)

○ (-) CD56, CD16 (=FCGR3A) (sc-type)

⑧ 종류 2. non-classical monocyte (N monocyte)

○ (+) FCGR3A (CD16), CDKN1C, MTSS1

○ (+) CD16, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, FCGR3A, CDKN1C, LST1, FCER1G, MS4A7, RHOC, S100A8, S100A9, CST3, C1QC, Elane1 (sc-type)

○ (+) LRRC25, CSF1R, LILRB2, FCGR3A, CD86, LST1, MS4A6A, CLEC7A, C3AR1, MS4A4A (Tabula Sapiens)

○ (-) CD14

○ (-) CD56 (sc-type)

⑨ 종류 3. intermediate monocyte (I monocyte)

○ (+) CD14, CD16, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, IL1B, S100A8, S100A9, CST3, C1QC, Elane1 (sc-type)

○ (+) FBXL5, BID, CD300E, FGL2, MPEG1, RNASE2, C3AR1, LILRB2, CYBB, MS4A6A (Tabula Sapiens)

○ (-) CD56 (sc-type)

⑿ B-5. MDSC(myeloid-derived suppressor cell)

① (+) Gr-1, CD11b

② 종류 1. eMDSC(early-stage MDSC)

○ (+) CD33

○ (-) HLA-DR, Lin

③ 종류 2. PMN-MDSC (polymorphonuclear MDSC)

○ (+) ITGAM (CD11b), CD33, CD15, CEACAM8 (CD66b), Ly6G

○ (-) CD14, Ly6C, HLA-DR

○ (low) Ly6C

④ 종류 3. M-MDSC (monocytic MDSC)

○ (+) ITGAM (CD11b), CD33, CD14

○ (-) HLA-DR, CD15, Ly6C, Ly6G

○ (low) HLA-DR

○ (high) Ly6C

⒀ B-6. Monoblast

⒁ B-7. Promonocyte

⒂ 대분류 2. erythrocyte (erythroid, 적혈구)

① (+) Hbb-bt, Hbb-bs, Hba-a2, Hba-a1, Car2, GATA1, E2f2, Fam46c, Slc25a37, Tfrc, Tmod1

② (+) ALAS2, HBQ1, HBM, EPB42, HBB, HBD, HBA1, HBA2, SLC4A1, TRIM58 (Tabula Sapiens)

③ 종류 1. erythroblast

④ 종류 2. erythroid-like and erythroid precursor cells

○ (+) ALAS2, HBB, HBA1, HBA2, GYPB, AHSP, HBM, FECH, BPGM, HBD, HEMGN, HMBS, NCOA4, SLC4A1, SLC25A39, SLC25A37, EPB42,GYPC, SNCA (PanglaoDB)

⑤ 종류 3. reticulocyte

⒃ 대분류 3. megakaryocytes (거핵세포) : 골수에서 혈소판 생성

① (+) CD61, CD41, CD42b, CD41a, CD42a, CXCR4, CD110 (sc-type)

② 종류 1. platelet (혈소판)

○ (+) CD41, CD42b, CD61, CD31, PPBP, PF4, GNG11, SDPR, CLU, CD41, CD110 (sc-type)

○ (+) RUFY1, NRGN, LY6G6F, PRKAR2B, MTURN, MMD, TSPAN33, PF4, CTSA, GP9 (Tabula Sapiens)

○ (+) CCL5, ITGA2B, PF4, F13A1, GP9, NCOA4, RGS18, PPBP, TREML1, CD9, NRGN, OST4, SPARC, GPX1, CAVIN2, PPDPF, MYL9, MAP3K7CL, GNG11, GRAP2, MPIG6B, ARHGDIB, CDKN2D, HLA-A, PDLIM1, SRGN (PanglaoDB)

⒄ 대분류 4. progenitor (전구세포)

① common lymphoid progenitor (CLP)

○ (+) CD34, CD38, CD10, CD45RA

② common myeloid progenitor (CMP)

○ (+) CD34, CD38, CD135

○ (+) RP11-620J15.3, PRSS57, DPPA4, CYTL1, GATA1, KLF1, RP11-354E11.2, AC002454.1, MYB, SPTA1 (Tabula Sapiens)

○ (-) CD7, CD10, CD45RA, CD90/Thy1

③ early progenitor

○ (+) Epha5, Tcf4, Erbb4

④ erythroid lineage cell

○ (+) GMPR, SLC25A39, HBA2, HBA1, HBB, HBQ1, SNCA, HBD, ALAS2, CA1 (Tabula Sapiens)

○ (+) LOC105883507, LOC105856254, AHSP, GPX1, PRDX2, LOC105856252, CA2, LOC105856255, RPS12, BLVRB (Tabula Microcebus)

⑤ erythroid progenitor

○ (+) Ter119, Abcb4, Ammecr1, Myh10, Podxl, Tmem56

○ (+) FAM178B, RHAG, KLF1, SPTA1, GATA1, GFI1B, KCNH2, KEL, RP11-620J15.3, CA1 (Tabula Sapiens)

○ (+) LOC105883507, RPS18, RPS12, ZC3H10, RPLP1, RPL13, RPS20, RPS5, RPL10, RPS14 (Tabula Microcebus)

○ (+) PTPRC, GYPA (CD235a), RUVBL1, TFRC (CD71), FOLR1, CD36, ITGA4, HBB, CD235a, HBD, CA1 (sc-type)

⑥ granulocyte-monocyte progenitor (GMP)

○ (+) CD34, CD38, CD45RA, CD123, CD135

○ (-) CD10

⑦ hematopoietic stem cell (HSC)

○ (+) CD34, CD45, CD49, CD90/Thy1, Cd150, Vcam1

○ (+) PRSS57, AVP, CRHBP, DPPA4, PINK2, CYTL1, MYB, KIAA0125, MLLT3, RP11-620J15.3 (Tabula Sapiens)

○ (+) Ctsg, Mpo, Prtn3, Elane, Nkx2-3, Ms4a3, Kcnk12, Prss57, Muc13, Bex6 (Tabula Muris)

○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31, Nestin, OCT4, CD117, KDR, CXCL8, AVP, CRHBP, ALDH1A1, CD49, CD90, CD69, CD24, CD45RA, Keratin-19, ASPM, CD10, CD123, ABCG2, CD135, CD49f, EpCAM, Keratin-7, SCA-1, CD14, CD150, CD271, HLA-DR (sc-type)

○ (-) CD38, CD45RA, Cd127, Cd135, PTPRC

⑧ megakaryocyte–erythroid progenitor (MEP)

○ (+) CD34, CD38

○ (-) CD7, CD10, CD45RA, CD135, IL3Rα

⑨ mesenchymal stem cell (MSC)

○ (+) VIM (vimentin), Vim

○ (+) THBS4, SMOC2, LINC01088, BMPER, GFRA1, PQLC2L, CILP, LAMA2, NEGR1, VGLL3 (Tabula Sapiens)

○ (+) Ifi205, Ptx3, Ccl11, Lrrn4cl, Saa1, Tnfaip6, Scg3, Stmn4, D630033O11Rik, Mt2 (Tabula Muris)

○ (+) GSN, DCN, LOC105866476, APOD, IGFBP3, JUNB, LOC105866554, EGR1, FOS, CHIT1 (Tabula Microcebus)

○ 종류 1. mesenchymal cell

○ (+) Hao1, 3110079O15Rik, Ucma, Col9a1, Wif1, Mia1, Hapln1, Lect1, Clec3a, Acan (Tabula Muris)

⑩ multi-potent progenitor (MPP)

○ (+) CD34

○ (-) CD38, CD45RA, CD90/Thy1, PTPRC

⑪ plasmablast

○ (+) Cd38, MHC class II, CD27, CD38, CD80

○ (+) ZNF587P1, CTD-2031P19.4, MTND5Pp11, AC074289.1, ZWINT, RP11-380M21.2, CDC42P6, PHTF1, RNU4-1, CEP128 (Tabula Sapiens)

⑫ progenitor cell

○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31 (PECAM1), Nestin, OCT4, CD117, KDR, AVP, CRHBP, ALDH1A1, STMN1, CD38, PTPRC, CD135 (sc-type)

⒅ 조직 1. PBMC(peripheral blood mononuclear cell)

⒆ 조직 2. BALF(bronchoalveolar lavage fluid)

⒇ 조직 3. 암(tumor)

① tumor infiltrating lymphocyte (TIL)

○ (+) CD45, CD3

⒇ 조직 4. pancreatic immune cell

① immune system cell

○ (+) MS4A1, CD19, CD4, CD8A, CD7, CTLA4, CD27, CCR7, CYTIP, IGHD, CD38, IL2RA, ISG20, SELL, IL7R, FOXP3, IGKC, IGLC3, IGLC2, CD79A, CD68, CD163, CD14, ITGAM, MRC1, MS4A7, CD3D, CD3E, CD3G (sc-type)

② mast cell

○ (+) KIT, ENPP3, IL2RA, ISG20, SLC18A2, CD9, FCER1A, TPSB2, FCER2 (sc-type)

③ mesenchymal cell

○ (+) ITGB1, NT5E, THY1, ENG, KIT, ALCAM (sc-type)

④ pancreatic progenitor cell

○ (+) ONECUT1, PDX1, PTF1A, CXCR4, ISL1, NKX2-2, EPAS1, ARX, NEUROG3, SOX9, RPL23A, CTNNB1, YAP1, RGS16, MFNG (sc-type)

⑤ pancreatic stellate cell

○ (+) TIMP1, RGS5, SPON2, GEM, DYNLT1, PDGFRB, KRT10, CYGB, CCN2, MMP14, NDUFA4L2, PDGFRA, INHBA, TGFB1 (sc-type)

○ (+) SNRPE, FAM162B, CDK4, NGFR, SEPT4, PTH1R, HEYL, ARHGAP42, ARHGEF17, SYDE1 (Tabula Sapiens)

○ (+) TIMP1, SPON2, GEM, DYNLT1, PDGFRB, KRT10, MMP14, NDUFA4L2, COL6A1, FN1, COL4A1, COL6A2, MGP, COL3A1, SPARC, COL1A1, TIMP3, TNFAIP6, COL1A2, SFRP2, COL6A3, THY1 (PanglaoDB)

⑥ peri-islet Schwann cell

○ (+) MPZ, EGFL8, GFRA1, OLFML2A, GULP1, SLITRK6, VGLL3, GFRA3, INSC, SLITRK2, FIGN, LRRTM1, SEMA3B, NGFR, PNLIPRP1, GFRA2 (sc-type)

○ (+) MPZ, OLFML2A, GULP1, GFRA3, INSC, SLITRK2, FIGN, SEMA3B, NGFR (PanglaoDB)

⒇ 조직 5. liver immune cell

① immune system cell

○ (+) CD19, MS4A1, IL2RA, PTPRC, CD4, CD8A, CD3D, CD3E, CD3G, CD11c, CD14, CD16, CD56, CD16, CD42b, CD7, CD8, IgD, CD38, CD24, CD20, CD14, CD16, HLA-DR, CD11b, CD11c, CD123, CD15, CD33, CD66b, CD27, CD94, CD45 (sc-type)

② Kupffer cell

○ (+) CLEC4F, ID3, ZEB2, LXRα

③ liver progenitor cell

○ (+) KRT7, KRT19 (sc-type)

④ mast cell

○ (+) KIT, ENPP3, IL2RA, ISG20, SLC18A2, CD9, FCER1A, TPSB2, FCER2 (sc-type)

⑤ mesenchymal cell

○ (+) CD44, ENG, NT5E, ITGB1, THY1 (sc-type)

⑥ monocyte

○ (+) FCGR3A, FCGR3B, CD14, Elane1 (sc-type)

⑦ macrophage

○ (+) Abcc3, Adgre1, Itgam, Mertk, Mrc1, Sdc3

⑧ myeloid

○ (+) Cd34, Rassf4

⑨ neutrophil

○ (+) Arsb, B4galt6, Gca, Olr1, Sgms2

⒇ 조직 6. eye immune cell

① microglial cell

② eye immune cell

○ (+) CD25, CD69, CD4, CD3, ITGAM, C1qa, Fcer1g, CD19, CD20, Trac, Ltb, Cd52, Trbc2 (sc-type)

⒇ 조직 7. kidney immune cell

① immune cell

○ (+) CD19, IGHA2, IGHG3, IGHM, IGKC, JCHAIN, CD40, CD79A, CPNE5, FCRL5, HLA-DRA, IGHA1, IGHG1, IGHG2, IGKV1-12, IGLC2, IGLC3, IGLC7, IGLL5, MS4A1, MZB1, PKHD1L1, PNOC, POU2AF1, TNFRSF13C, CD3D, TRAC, IL7R, CD3E, CD8A, TRBC2, CD52, FCGR3A, IL32, KLRD1, CD68, CXCL8, FCGR3B, MNDA, KIT, PTGS2, SLC18A2, Trac, Ltb, Cd52, Trbc2, Shisa5 (sc-type)

② hematopoietic cell

○ (+) CORO1A, MNDA, SRGN, HLA-DPA1, LST1 (sc-type)

⒇ 조직 8. brain immune cell

① immune system cell

○ (+) MS4A1, CCR6, CXCR3, CD4, IL2RA, ISG20, TNFRSF8, Trac, Ltb, Cd52 (sc-type)

② microglial cell

○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1 (sc-type)

○ (+) IBA1, Cd68, TMEM19, P2RY12, SALL1

⒇ 조직 9. lung immune cell

① alveolar macrophage

○ (+) HLA-DR, CD169, CD206, SIGLECF, CD11c, PPARγ, C/EBPβ

○ (+) FTH1, FTL, TMSB4X, TYROBP, C1QA, RPLP1, LGALS3, CTSD, ACTB, RPS18 (Tabula Miceocebus)

○ (+) ABCG1, CCL3, CD36, CLEC7A, CSF2RB, CXCL2, G0S2, GAL, GDA, GNGT2, GPNMB, IL18, IL1B, ITGAX, KLHDC4, MARCO, MCEMP1, MPP1, MRC1, OLR1, PLET1, S100A4, TLR2, TNFAIP2, TRIM25 (sc-type)

② interstitial macrophage

○ (+) HLA-DR, CD206

○ (-) CD169

③ immune system cell

○ (+) ADGRE1, ARG1, BIRC5, CCL17, CCL18, CD14, CD163, CD19, CD22, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD68, CD74, CD80, CD83, CD86, CD8A, CD8B, CDCA3, CDK1, CEBPE, CR2, CSF1R, EAF2, FCER2, FCGR3A, FLT3, GIMAP3P, HLA-DRA, HMMR, IGHM, IL2RA, ITGAE, ITGAM, ITGAX, LAX1, MS4A14, MZB1, NRP1, NUSAP1, PAX5, PRG2, PTPRC, SLPI, THBD, TNFRSF17, TRBC1, XCR1 (sc-type)

⒇ 조직 10. adrenal immune cell

① myeloid cell

○ (+) MS4A14, LILRA1, RP11-554D14.6, AC007040.8, MS4A7, RP11-489O18.1, CLEC10A, MS4A4A, RN7SL138P, CD163, CD14, SIGLEC1, VSIG4, CLEC7A, LILRA2 (sc-type)

② erythroblast

○ (+) TPSAB1, CTD-2008P7.9, RP11-85G21.3, CTSE, CTA-392E5.1, EIF5AP2, CTA-363E6.6, C17orf99, SLC4A1, TRIM10, MIR144, ART4, AHSP, GYPA, HBM (sc-type)

③ lymphoid cell

○ (+) GZMH, XCL1, KLRC3, RP11-94L15.2, GZMA, IL2RB, TRAT1, SH2D1A, DTHD1, CD3E, ZNF831, GNLY, PRF1, IGHD, THEMIS (sc-type)

⒇ 조직 11. heart immune cell

① lymphoid cell

○ (+) GZMB, FCRL2, KLRC2, XCL1, LINC00861, PRF1, CD3G, SH2D1B, ANTXRLP1, VPREB3, SH2D1A, CRTAM, CXCR6, RP11-94L15.2, GZMK (sc-type)

② myeloid cell

○ (+) XCR1, TMPRSS4-AS1, TIMD4, PRTN3, MMP9, CD86, CLEC5A, SIGLEC1, CLEC7A, C1QC, P2RY13, FCN1, CSTA, CD300LF, MS4A6A (sc-type)

③ erythroblast

○ (+) RP5-857K21.7, CENPW, SLC46A1, GSPT2, RHCE, SLC7A11, P2RX6, SKA1, FARSA, ZNF90, TMCC2, RP11-225B17.2, TMEM161A, ZNF583, ENPP4 (sc-type)

⒇ 조직 12. intestine immune cell

① erythroblast

○ (+) AHSP, SPTA1, HBG2, HBA2, HBM, HBG1, HBA1, SLC4A1, HBB, GYPA, HEMGN, HBZ, ALAS2, MIR144, MYL4 (sc-type)

② myeloid cell

○ (+) VSIG4, RPL32P1, CD207, AP000439.1, HCAR3, C5orf20, AC010492.4, P2RY13, LILRB2, LILRB5, IL1B, C1QB, CD163, C1QC, DNASE1L3 (sc-type)

③ lymphoid cell

○ (+) IL17A, ICOS, SH2D1A, GZMK, RP11-553L6.2, TRGC1, RP11-104L21.3, TRDC, GZMA, VPREB1, CCR4,LTA, NCR2, CD247, RP11-94L15.2 (sc-type)

⒇ 조직 13. muscle immune cell

① 종류 1. erythroblast

○ (+) RHAG, GYPA, AHSP, GYPB, HBZ, ALAS2, SLC4A1, SLC14A1, EIF5AP2, HBM, HBA1, EPB42, RP11-57H12.2, ALS2CR12, SLC25A37 (sc-type)

② 종류 2. myeloid cell

○ (+) FCN1, MS4A4E, TMPRSS4-AS1, CD86, FLT3, P2RY13, IL10RA, FOLR2, MNDA, HLA-DQB1, MS4A4A, AMICA1, CYTH4, MS4A6A, CFP (sc-type)

③ 종류 3. lymphoid cell

○ (+) IL7R, CD8A, NKG7, CD247, NCR1, RP11-61O1.1, TRAC, CD3E, ITK, CD2, MATK, RP11-444A22.1, SYTL1, IL2RB, GZMA (sc-type)

⒇ 조직 14. placenta immune cell

① 종류 1. lymphoid cell

○ (+) IGJ, IGHM, KLRC3, GZMH, PTGDR, IGHGP, IKZF3, IFNG-AS1, TIGIT, KLRC2, LCK, ANKRD36BP2, TNFRSF18, IGHG3, LINC00861 (sc-type)

② 종류 2. myeloid cell

○ (+) SIGLEC10, RP11-1143G9.4, LYZ, ADAMDEC1, LILRB2, HLA-DRB5, SDS, HLA-DOA, SIGLEC1, MMP9, LILRB4, C1QB, TLR2, TLR7, S100A8 (sc-type)

⒇ 조직 15. spleen immune cell

① 종류 1. lymphoid cell

○ (+) RN7SL337P, KLRC4-KLRK1, RP11-553L6.2, RP11-861A13.4, RP11-38J22.6, ZNF860, RP11-693J15.5, RP11-61O1.1, FCRL3, CTD-2215E18.1, RP5-1028K7.2, IKZF3, LINC00861, IL9RP3, VAV3-AS1 (sc-type)

② 종류 2. myeloid cell

○ (+) CLEC9A, RP11-489O18.1, RP3-522P13.3, RP11-807H22.7, RP11-1080G15.1, FCN1, EMR4P, TMPRSS4-AS1, RP11-157G21.2, CSF2RA, OSCAR, RP3-522D1.1, CD163L1, RUFY4, DLEU7-AS1 (sc-type)

③ 종류 3. erythroblast

○ (+) HDC, PRSS57, EIF5AP2, PPAPDC1A, MTL5, CTA-392E5.1, ACSBG1, RP5-964N17.1, GYPA, SLC25A21, RP11-146I2.1, MIR144, SLC2A14, CTA-363E6.6, SLC4A1 (sc-type)

④ 종류 4. white pulp macrophage

○ (+) CD68

○ (-) F4/80

⑤ 종류 5. marginal zone macrophage

○ (+) SIGN-R1, LXRα

⑥ 종류 6. red pulp macrophage

○ (+) VCAM1, Spi-C

○ (-) CD11b

⒇ 조직 16. stomach immune cell

① 종류 1. erythroblast

○ (+) KLF1, SLC4A1, HBM, NFE2, HBZ, GYPB, HBG2, HBB, ALAS2, SPTA1, HBA1, HEMGN, RNF224, HBG1, HBA2 (sc-type)

② 종류 2. myeloid cell

○ (+) C1QC, HLA-DQB1, MS4A6A, CD14, C1QB, CD163L1, IGSF6, CCDC26, C1QA, NCF2, HLA-DRB1, HLA-DRB5, CLEC7A, MS4A7, HLA-DPA1 (sc-type)

③ 종류 3. lymphoid cell

○ (+) ICOS, CD27, NKG7, CD28, CD3D, CHI3L2, TRAT1, THEMIS, CD52, KLRB1, CD79B, CCL5, TRBC2, SIRPG, CD3E (sc-type)

⒇ 조직 17. thymic immune cell

① 종류 1. antigen presenting cell

○ (+) IL1RN, EBI3, FGD2, MCOLN2, MMP9, TLR10, LINC00996, CD80, CXCL10, SLAMF7, P2RY13, SLC24A4, HCK, C1QB, LYZ (sc-type)

⒇ 조직 18. bladder immune cell

① 종류 1. B cell

② 종류 2. macrophage

③ 종류 3. mast cell

④ 종류 4. NK cell

⑤ 종류 5. plasma cell

⑥ 종류 6. plasmacytoid dendritic cell

⑦ 종류 7. T cell

5. 유형 4. stromal cell (기질세포) [목차]

⑴ 개요 : pan-stromal cell

① (+) Slc7a10, Slc38a5, Slc36a2, Adrb3, Scn3a, C7, Prkg2, A330076H08Rik, Inmt, Foxf2 (Tabula Muris)

② (+) DCN, PAPPA, SFRP4, THBS2, LY86, CXCL14, FOXF1, COL10A1, ACTG2, APBB1IP, SH2D1A, SULF1, MSR1, C3AR1, FAP (SCEVAN)

⑵ 조직 1. connective tissue

① 개요

○ (+) ADAMTS5, COL5A2, GPSM2, ITGBL1, TNXB, GPR133, CHRDL1, NBL1, SEMA3C, ELN (Tabula Sapiens)

② 종류 1. adipocyte

○ (+) ADH1B, ADIPOQ, ANKRD29, CAVIN2, CLEC14A, EGFL7, HOXD8, HOXD9, KDR, LPL, MMRN2, NOSTRIN, PDCD1LG2, PDE4A, RAMP2, RAPGEF3, SOX18, TFAP2A, TIMP4, UCP1

○ (+) STAT6, TFE3, APPL2, APOL6, PXMP2, CAVIN1, MMP2, COL6A2, MT2A, TIMP1, METRN, METRNL, MYO1C, NQO1, SYAP1, CRNDE, TSPO, LRP1, HOXC9 (PanglaoDB)

③ 종류 2. preadipocyte

④ 종류 3. chondrocyte

○ (+) Sox9, Col2a1

○ 3-1. columnar chondrocyte

○ (+) Sulf1, Robo1

○ 3-2. early hypertrophic chondrocyte

○ (+) Runx2, Ibsp

○ 3-3. late hypertrophic chondrocyte

○ (+) Spp1, Mmp9

○ 3-4. nucleus pulposus cells

○ (+) Pax1, Fmod

○ 3-5. prehypertrophic chondrocyte

○ (+) Prrx1, Fbxl7

○ 3-6. round chondrocyte

○ (+) Sox5, Sox9

⑤ 종류 4. fat cell

○ (+) GABRA4, SCD, CIDEA, PNLIPRP3, AWAT2, ACSBG1, KRT79, LCN1, GLDC, FAR2 (Tabula Sapiens)

⑥ 종류 5. fibroblast

○ (+) DCN, PRELP, RGS5, ACTA2 (α-SMA), PDGFRB (PDGFRβ), CD29, FAP, FSP1, CAV1(caveolin 1), Apod, Apoe, IGF1, MMP1, MMP12, PIM1, TAC1, TCEAL7, FBLN2, Fgr, Ccr2, Ccbe1, MMP11, COL12A1

○ (+) CD248, SFRP2, COL1A1, GAS1, CCDC80, PCOLCE2, ISLR, COL5A1, PLA2G2A, FBN1 (Tabula Sapiens)

○ (+) DCN, APOD, CFD, MGP, GSN, APOE, FBLN1, LGALS1, MMP2, LUM (Tabula Microcebus)

○ (+) LUM, COL6A2, MMP2, IGFBP6, CDH11, COL6A3, C1S, RARRES2, SPON2, CTGF, COL1A2, COL3A1, VIM, FSTL1, GSN, SPARC, S100A4, COL1A1, MGP, SERPINH1, DCN, EGR1, FOSB, KLF6, STAT3, CXCL14 (PanglaoDB)

○ (+) AMOTL2, DPT, ISLR, SVEP1, FGF7, ELN, TCF21, ASPN, COL14A1, PRDX4, S1PR2, C7, COL6A3, MMP2, VIM (SCEVAN)

○ 5-1. activated fibroblast

○ (+) COL1A1, COL1A2, COL3A1, COL22A1, FAP, NOX4, POSTN, THBS4, NNMT, COL5A1, SPP1, FN1, CTHRC

○ 5-2. alveolar fibroblast

○ (+) MGP, APOD, APOE, DCN, JUN, CTGF, FOS, MFAP4, SELENOP, JUNB (Tabula Microcebus)

○ 5-3. cancer-associated fibroblast (CAF)

○ (+) FAP, THY1, FST1, BGN, DCN, COL1A1, COL1A2, COL3A1, COL5A1, COL6A1, COL6A2, COL6A3, CD90.2, FSP-1

○ (-) CD45

○ 5-3-1. CAF-S1 (immunosuppressive function)

○ 5-3-1-1. myCAF (myofibroblastic)

○ (+) NDUFA4L2, MAP1B, SPARCL1, RGS5, TPPP3, MCAM

○ (+) HSD17B2, TCF21, FOXF1, NR2F1, PDPN, PLAT, EMILIN1, PDGFRA, APCDD1, CYGB (Tabula Sapiens)

○ (+) APOD, APOE, MGP, COL1A2, LGALS1, DCN, COL1A1, TAGLN, FBLN1, CFD (Tabula Microcebus)

○ 종류 1. ecm-myCAF

○ (+) LRRC15, GBJ2

○ 종류 2. TGFβ-myCAF

○ 종류 3. wound-myCAF

○ 종류 4. IFNαβ-myCAF

○ 종류 5. acto-myCAF

○ 5-3-1-2. iCAF (inflammatory)

○ 종류 1. detox-iCAF

○ (+) ADH1B, GPX3

○ 종류 2. IL-iCAF

○ 종류 3. IFNγ-iCAF

○ 5-3-2. CAF-S2

○ 5-3-3. CAF-S3 (abundant in healthy tissue)

○ 5-3-4. CAF-S4 (pro-metastatic function)

○ 5-3-5. CAFap (antigen-presenting CAF)

○ (+) ACTA2, HLA-DRA, CD74

○ 5-4. fibroblast of breast

○ (+) ARSG, THBS2, JHDM1D-AS1, CLMP, RSPO3, TWIST1, MMP3, LOX, FRMD4A, SLC7A2 (Tabula Sapiens)

○ 5-5. fibroblast of cardiac tissue

○ (+) CDH19, CRLF1, FMOD, FAIM2, ADAMTSL2, ABCA6, PRELP, MATN2, PLEKHH2, FIBIN (Tabula Sapiens)

○ 5-6. myofibroblast

○ (+) ACTA2, CDH11, CTHRC1

⑦ 종류 6. goblet cell

○ (+) TFF3, FCGBP, STARD10, TSPAN1, CKB, MUC4, GOLM1, TMC5, PIGR, SLC26A2 (Tabula Sapiens)

⑧ 종류 7. limbal stromal cell

⑨ 종류 8. melanocyte

○ (+) MIA, TYR, SLC45A2, CDH19, PMEL

○ (+) TYR, MITF, TRPM1, MLANA, TYRP1, DCT, BCAN, PMEL, CHCHD6, GPR143 (Tabula Sapiens)

⑩ 종류 9. spindle cell

⑶ 조직 2. muscle

① (+) CMSS1, MT1A, AXL, SLC7A2, PHLDB2, ADAMTS4, KCNE4, VASN, TWIST1, MTHFD2 (Tabula Sapiens)

② 종류 1. bronchial smooth muscle cell

○ (+) ENAH, PDLIM7, NTRK3, RASL12, DES, AOC3, GUCY1B3, C2orf40, CASQ2, ACTG2 (Tabula Sapiens)

③ 종류 2. cardiac muscle cell (cardiomyocyte, 심근세포)

○ (+) Myh6, Myh7, Tnnc1

○ (+) MYH6, TECRL, COL2A1, AC020909.2, NKX2-5, FBN2, TNNT2, MYL4, MYL7, ACTC1 (Tabula Sapiens)

○ (+) RP11-439H8.4, RNA5SP327, CTD-2552K11.2, Y_RNA, AC018464.3, HHATL, BMP10, RP11-461A8.4, UGT2B4, PRSS42, WI2-1896O14.1, FABP2, EPN3, RP11-406O23.2, AC009878.2 (sc-type)

④ 종류 3. skeletal muscle cell

○ (+) RP11-755O11.2, ASB15, RP11-456H18.2, RPL7P3, PVALB, RN7SL365P, RP11-432J24.5, C8orf22, ASB10, RP5-921G16.2, CLDN9, RP5-1039K5.13, AC137723.5, RP11-255G21.1, AC093063.2 (sc-type)

○ 3-1. myoblast

○ 3-2. myocyte

○ 3-3. satellite cell

○ (+) Sds, Myod1, Chrdl2, Asb5, Fam132b, Popdc3, Chodl, Ank1, Gdnf, Des (Tabula Muris)

⑤ 종류 4. fast muscle cell

○ (+) MYH2, MYL1, KLHL40, TNNC2, TNNI2, MYLPF, RPL3L, ATP2A1, FHL3, MYBPC2 (Tabula Sapiens)

⑥ 종류 5. slow muscle cell

○ (+) MYL1, RP11-451G4.2, RPL3L, MYL6B, MYL2, ANKRD2, MYOZ1, TNNC2, CKM, NRAP (Tabula Sapiens)

⑦ 종류 6. smooth muscle cell

○ (+) AKR1C1, AVPR1A, CCL8, CRISPLD2, CTH, FOXC2, FSTL3, LARS, MYH11, PDGFRB, PDK4, SSTR2, THAP2, TAGLN, Myh11, Pde8b

○ (+) OR51E2, AC131025.8, ADORA2B, MYH11, SLC38A11, MIR143HG, MIR145, RP11-1101K5.1, P2RX3, GPR176, ANO1, OR51E1, CORIN, CACNA1C-IT3, TMC4 (sc-type)

○ (+) MYH10, ITGA8, NOV, SUSD5, SORBS1, MYH11, BGN, CNN1, SMTN, LTBP1 (Tabula Sapiens)

○ (+) ACTA2, CNN1, NOTCH3, MY11, ACTG2, SOD3, LMOD1, MSRB3, BGN, MYL9, MYLK, SNCG, PLN (PanglaoDB)

○ 6-1. airway smooth muscle cell

○ 6-2. myoepithelial cell

○ (+) CNN1, MYH11, ACTG2, MYLK, MYL9 (PanglaoDB)

○ 6-3. myofibroblast

○ 6-4. pulmonary vascular smooth muscle cell

○ 6-5. vascular smooth muscle cell

○ (+) S100A6, ADIRF, TAGLN, TPM2, ACTA2, MUSTN1, CRIP1, C5H11orf96, TPM1, DSTN (Tabula Microcebus)

⑧ 종류 7. tendon cell

○ (+) FMOD, THBS4, TNMD, MYOC, XG, ITGA10, FIBIN, CDO1, GEM, CILP (Tabula Sapiens)

⑨ 종류 8. tongue muscle cell

○ (+) PHACTR3, PAX7, TLN2, CHRNA1, KLHL41, MAP1A, MUSK, H19, HTRA3, NPTX2 (Tabula Sapiens)

⑩ 종류 9. vascular associated smooth muscle cell

○ (+) RERGL, FHL5, ACTA2, CNN1, MRGPRF, MYLK, ACTG2, TBX2, AOC3, PTP4A3 (Tabula Sapiens)

⑪ 종류 10. megakaryocyte

○ (+) PF4, ITGA2B, LIPH, ELOVL7, GP6, ITGB3, PTGS1, RP11-480G7.1, RP11-170N16.2, C3orf55, RP4-655J12.4, TUBB1, DCLRE1A, TMEM40, GNAZ (sc-type)

⑫ 종류 11. Schwann cell

○ (+) UGT8, POU3F1, PMP2, GFRA3, KCNC2, MPZ, SOX10, PTPRZ1, COL20A1, LINC01037, BCAN, C2orf72, C10orf82, RP11-946L20.2, MAG (sc-type)

⑬ 종류 12. stromal cell

○ (+) WSCD2, C13orf45, LINC00645, RP1-300G12.2, RP11-217C7.1, RP11-332E3.2, RP11-473E2.4, CTD-2555C10.3, RP11-342A23.1, WNT10B, ACKR4, DIO3, CCDC129, ZCCHC5, RP11-38H17.1 (sc-type)

⑭ 종류 13. satellite cell

○ (+) AC004014.3, MYEOV, TACR3, GDPD4, USP44, RGR, RP11-320P7.2, FAM132B, GPR123, CTB-175P5.4, ENPP7P10, CHRDL2, PAX7, RP11-706J10.1, MAPK15 (sc-type)

⑮ 종류 14. myometrial cell

○ (+) C16orf45, ACTG2, FHL5, KCNMB1, DES, CNN1, RRAD, HILPDA, LMCD1, PPP1R14A (Tabula Sapiens)

⑷ 조직 3. stem cell

① (+) DMRTA2, FGFR3, RASSF6, COL17A1, PAX6, CHL1, TNS4, KRT12, COL7A1, SYT8 (Tabula Sapiens)

② 종류 1. brain neural stem cell

○ (+) SOX2, PROM1, NES, SOX9 (sc-type)

③ 종류 2. cancer stem cell

○ 2-1. kidney cancer stem cell

○ (+) EPCAM

○ 2-2. pancreas cancer stem cell

○ (+) CD24, CD44, FLOT2

○ 2-3. liver cancer stem cell

○ (+) ANPEP, CD44, EPCAM, POU5F1, PROM1, THY1

○ 2-4. lung cancer stem cell

○ (+) ABCG2, ALCAM, ALDH1A1, BMI1, CD24, CD44, KIT, NANOG, NES, PDPN, POU5F1, PROM1, SOX2, THY1

○ 2-5. brain cancer stem cell

○ (+) FUT4, MSI1, NES, PROM1, SOX2, THY1

④ 종류 3. immune system stem cell

○ 3-1. pancreas immune system stem cell

○ 3-2. liver immune stem cell

○ 3-3. brain immune stem cell

○ (+) MS4A1, CCR6, CXCR3, CD4, IL2RA, ISG20, TNFRSF8, Trac, Ltb, Cd52 (sc-type)

○ 3-4. lung immune stem cell

⑤ 종류 4. mesenchymal stem cell

○ 4-1. liver mesenchymal stem cell

○ (+) CD44, ENG, NT5E, ITGB1, THY1 (sc-type)

⑥ 종류 5. skeletal muscle satellite stem cell

○ (+) MYF5, DLK1, KLHL41, PPM1L, CADM2, GPM6B, PON2, SGCA, WEE1, TPD52L1

⑦ 종류 6. limbal stem cell

⑧ 종류 7. epidermal stem cell

○ (+) ITGA6, ITGB1

⑸ 조직 4. bone stroma

① 종류 1. osteoblast

○ (+) BGLAP, COL1A1, IBSP, Bglap, Alpl

② 종류 2. osteoclast

○ (+) TRAP, calcitonin receptor (CTR), cathepsin K, NFATC1, SMAD2/3, RXR

③ 종류 3. osteocyte

④ 종류 4. osteoclast precursor cell

⑹ 조직 5. hepatic stroma (liver stroma)

① 종류 1. hematopoietic cell

○ (+) CD34, PTPRC

② 종류 2. 간 성상세포(hepatic stellate cell, HSC) : liver fibrogenesis 개시 및 발달에 필수적. 내피세포 및 간 외피세포와 상호작용

○ (+) Desmin, Cd48, Ddx4, Flt3, Kit, Mecom, Procr, Runx1, Slamf1

○ (+) CYGB, PPARG, PDGFRA, RGS5, PPARA, FOXF1, ALB, NR1H4, CCN2, SEMA7A, WT1, FGF10, GFAP, NGFR, VEGFA, ACTA2, MYB, DES, FAP, SLC8A1, RELN, SYP, VCL, TIMP1, COL1A1, TAGLN, COL1A2, COL3A1, SPARC, RBP1, DCN, MYL9, TPM2, MEG3, BGN, IGFBP7, IGFBP3, CCN1, OLFML3, IGFBP6, CCL2, COLEC11, HGF (sc-type)

○ (+) PPARG, ALB, CTGF, ACTA2, VCL, TIMP1, COL1A1, COL1A2, COL3A1, SPARC, RBP1, DCN, MYL9, TPM2, MEG3, BGN, IGFBP7, IGFBP3, CYR61, OLFML3, IGFBP6, CCL2, COLEC11 (PanglaoDB)

③ 종류 3. hepatoblast

○ (+) AFP, ALB, CEBPA, KRT14, DLK1, CDH1, FOXM1, GGT1, HNF4A, PROX1, MAP2K4, SMAD5, KRT18, KRT8, HNF1B, HHEX, MET (sc-type)

④ 종류 4. hepatocyte : 간의 구성에서 60-80 %를 차지함

○ (+) ALB, Apoc4, Uox, Tat, Slc25a47, Cxadr, Gpd1, Hc, Proz, Pzp, Sardh

○ (+) AFP, HNF4A, KRT8, ALB, KRT18, FOSL1, EPPK1, UCP2, GCK, LRP5, SLC10A1, NOS2, ATP7B, GJB2, FGFR4, PROX1, CRP, SLC2A2, TFR2, KIF13B, LIPC, VDR, ASGR1, ARG1, G6PC, OTC, SERPINA1, ZHX2, HHEX, FOXA3, FOXA2, FOXA1, CYP2E1, CYP1A2, CEBPA, CDH1, GPC3, AHR, CPS1, GLS2, PCK1, TAT, WT1, PRRG4, SULT1A1, APOH, CTNNB1, ABCC3, FGB, AQP3, PLSCR1, FGA, APOB, ANG, ANXA13, SAT2, SFRP5, A1CF, APOA1, BNIP3, FGL1, PAH, SERPINA6, APOA2, AZGP1, FGG, APOC3, DEFB1, TM4SF4, GC, AMBP, ORM1, TTR, HAL, ASS1, SCD, HMGCS1, ACSS2, TM7SF2, SEC16B, SLBP, RND3, BCHE, GHR, ALDH6A1, MASP2, AKR1C1, HAMP, GLUL, ACLY, ASL, TMEM97, CP, SLPI, ACAT2, TM4SF5, MSMO1, LEPR, RCAN1, AR, RPP25L, HSD11B1, APOM, TKFC, G0S2, PON3, C1orf53, TTC36, FST, MCC, AQP9, GSTA2, NNT, SAA4, MRPS18C, OCIAD1, APOA5, ENTPD5, C4B, EID2, TP53INP2, ATIC, SERPINH1, SAMD5, GRB14, CD3G, RHOB, EPB41L4B, GPAT4, SPTBN1, SDC2, PHLDA1, WTAP, ACADM (sc-type)

○ (+) MAT1A, AGXT, KNG1, TAT, CRP, ITIH1, HPX, APOA2, CYP2E1, CPS1 (Tabula Sapiens)

○ (+) ALB, SERPINA1, APOH, FGB, FGA, APOA1, FGL1, APOA2, FGG, APOC3, AMBP, ORM1, TTR (PanglaoDB)

○ 4-1. periportal hepatoycyte

○ (+) SDS (gulconeogenesis), Alb, Cyp2f2, Sds (gulconeogenesis)

○ 4-2. pericentral hepatocyte (centrilobular hepatocyte)

○ (+) GLUL, CYP2E1, Cyp2e1, Gsta3

○ 응용. pericentral → periportal gradient (ref)

○ Glul, Oat, Cyp2a5, Mup9, Mup17, Cyp2c29, Cyp2e1, Mup11, Hamp, Ass1, Serpina1e, Cyp2f2, Alb, Mup20

⑺ 조직 6. eye stroma

① 종류 1. 양극세포(bipolar cell)

○ (+) NRSN1, SLC24A2, VSX2, CELF3, STMN4, MDGA2, TMEM179, TMEM196, GNG13, GNG3 (Tabula Sapiens)

○ 1-1. rod bipolar cell

○ (+) PRKCA, PCP4, RCVRN, SLC1A2, Car8, Sebox, Vsx2, Otx2, GRM3, KCNA4, KCNMA1, RORB, Cabp5, Og9x, Vstm2b, Casp7, Rpa1, GABRA1, LHX4 (sc-type)

○ 1-2. cone bipolar cell

○ (+) PCP4, RCVRN, SLC1A2, Car8, Scgn, Vsx2, Otx2, MIP, GNAS, ISL1, SLC1A7, GJD2, GNB3, GRIA4, TJP2, LRIT2, Cabp5, Scgn, Vsx1, GABRA1, LHX4, LHX3 (sc-type)

② 종류 2. muller cell

○ (+) Apoe, Glul, Rlbp1, Abca8a, Vim, Aldh1a1, RLBP1, GLUL, PAX6, CA8, EDN2, KCNJ2, PRSS56, RGR, ApoE, Aqp4 (sc-type)

○ (+) RLBP1, RAX, FABP7, GFAP, CRABP1, MT-TV, LINC00461, DEFB119, RGR, LINC00632 (Tabula Sapiens)

③ 종류 3. astrocyte

○ (+) PRDX6, SLC1a3, PAX2, Rlbp1, GFAP, S100B (sc-type)

④ 종류 4. retinal ganglion cell

○ (+) BMP4, GRIA4, GRM3, KCNJ2, MED1, NMT, POU6F2, ZIC2, SLC17a6, Pax6, THY1, Nefl, Pou4f2, SNCG, NRN1, Cerkl (sc-type)

○ (+) NHLH2, SMIM18, CCDC184, NKAIN3, SRRM3, NARF, CPNE4, CACNB3, SLC17A6, DNER, FXYD7, NEFM, SNCG (PanglaoDB)

⑤ 종류 5. retinal progenitor cell

○ (+) PAX6, CALB2, SIX6, RHO, SIX3, NEFH, LGR5, SAG, RAX, NOTCH1, HES1, MSI1, SOX9, KIT, PDGFRA, Og9x, Sfrp2, Fgf15 (sc-type)

⑥ 종류 6. GABAergic amacrine cell

○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln (sc-type)

⑦ 종류 7. 수평세포(horizontal cell)

○ (+) Rcvrn, Prox1, Ntrk1, Lhx1, Lim2, Calb2, CALB1, LIM1, DLG2, TFAP2B, ZEB2, Lim1 (sc-type)

⑧ 종류 8. 시냅스(synapse)

○ (+) SYP, DLG4, HOMER1, SLC32A1 (sc-type)

⑨ 종류 9. 섬유아세포(fibroblast)

○ (+) PAX6, COL1A1, TGFB1, ACTA2, ICAM1, FBLN1, CRHBP, FN1, PDGFRA (sc-type)

⑩ 종류 10. pericyte

○ (+) Kcnj8, Rgs5, Dlk1, Abcc9, SUR2B, DLK1, VCAM1 (sc-type)

⑪ 종류 11. exctracellular matrix cell

○ (+) ANTXR2, COL10A1, EFEMP1, LAMA2, SNTB1, TCF7L2, TGFBR1, TMEM98, VIPR2, ZIC2 (sc-type)

⑫ 종류 12. glycinergic amacrine cell

○ (+) Pax6, Tfap2a, Fut4, Calb2, Pvalb, Slc6a9, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, GlyT1, TgfB2, BE996002, Camkv, TCF4, Efna5, Dab1, Slc6a9 (sc-type)

⑬ 종류 13. cholinergic GABAergic amacrine cell

○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln, VAChT, Tac1, Scube2, Cpne4, Sox2, Slit, SCGN (sc-type)

⑭ 종류 14. Tachykinin GABAergic amacrine cell

⑮ 종류 15. starbust amacrine cell

○ (+) Pax6, Tfap2a, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, GAD1, CHAT, SLC5A7 (sc-type)

⑯ 종류 16. adipocyte

⑰ 종류 17. ciliary body

⑱ 종류 18. beam cell (A/B/X/Y) : fibroblast-like (ref)

⑲ 종류 19. JCT(juxtacanalicular tissue) cell

⑳ 종류 20. retina neuron layer

○ L1

○ L2

○ L3

○ L4

○ L5

○ L6

○ L7

○ L8

○ L9

○ L10

⑻ 조직 7. pancreatic stroma

① 종류 1. pancreatic acinar cell

○ (+) CTRB1, KLK1, RBPJL, PTF1A, CELA3A, PRSS1, SPINK1, ZG16, CEL, CELA2A, CPB1, CELA1, RNASE1, AMY2B, CPA2, CPA1, CELA3B, PNLIP, CTRB2, PLA2G1B, PRSS2, CLPS, REG1A, SYCN, PNLIPRP1, CTRC, REG3A, PRSS3, REG1B, CFB, GDF15, MUC1, C15orf48, AKR1C3, OLFM4, GSTA1, LGALS2, PDZK1IP1, RARRES2, CXCL17, GSTA2, ANPEP, LYZ, ANGPTL4, ALDOB (sc-type)

○ (+) AMY2A, CELA3B, CELA3A, CELA2A, CTRB2, CPA2, PRSS3P2, PNLIPRP1, CTRL, PNLIPRP2 (Tabula Sapiens)

○ (+) PRSS2, CPA1, CTRC, LOC105875474, LOC105873340, CTRB1, LOC105873633, CLPS, PLA2G1B, LOC105873613 (Tabula Microcebus)

○ (+) CTRB1, KLK1, CELA3A, PRSS1, SPINK1, CPB1, RNASE1, CPA2, CPA1, CELA3B, PNLIP, CTRB2, PLA2G1B, PRSS2, CLPS, REG1A, SYCN, PNLIPRP1, CTRC, REG3A, PRSS3, REG1B, GDF15, MUC1, C15ORF48, AKR1C3, OLFM4, GSTA1, LGALS2, PDZK1IP1, RARRES2, CXCL17, GSTA2, ANPEP, ALDOB (PanglaoDB)

② 종류 2. pancreatic alpha cell

○ (+) GCG, TTR, ARX, POU3F4, NKX2-2, RESP18, PYY, PCSK2, SLC38A5, TM4SF4, CRYBA2, NKX6-1, KCNK16, PCSK1, PRRG2, IRX2, ALDH1A1, PEMT, CHGA, SMIM24, F10, SCGN, SLC30A8, SH3GL2, SCGB2A1, FAP, DPP4, MAFB, PAX6, NEUROD1, PLCE1, GC, KLHL41, FEV, PTGER3, RFX6, SMARCA1, PGR, LDB2, IRX1, UCP2 (sc-type)

○ (+) GCG, TTR, PCSK2, TM4SF4, CRYBA2, ALDH1A1, PEMT, CHGA, SMIM24, F10, SCGN, SLC30A8, SCGB2A1, MAFB, NEUROD1, GC, FXYD5 (PanglaoDB)

③ 종류 3. pancreatic beta cell

○ (+) FXYD2, PDX1, INS, GCGR, JPH3, CD40, HAMP, EZH1, NTRK1, SLC2A2, NKX6-2, NPY, RIMS1, MAFA, EFNA5, LMX1A, NKX2-2, NKX6-1, PAX4, IAPP, PCSK2, G6PC2, SLC30A8, PCSK1, GJD2, SCGN, IGF2, SYT13, FFAR2, NPTX2, PFKFB2, EDARADD, HOPX, SH3GL2, ADCYAP1, SCGB2A1, CASR, MAFB, PAX6, NEUROD1, ISL1, TGFBR3, SMAD9, SIX3, SIX2, BMP5, PIR (sc-type)

○ (+) PDX1, INS, MAFA, NKX2-2, NKX6-1, IAPP, PCSK2, G6PC2, SLC30A8, PCSK1, GJD2, SCGN, SYT13, NPTX2, HOPX, ADCYAP1, SCGB2A1, MAFB, PAX6, NEUROD1, ISL1, DLK1, MEG3 (PanglaoDB)

④ 종류 4. pancreatic delta cell

○ (+) SST, PDX1, FFAR4, PCSK9, RBP4, PAX4, RESP18, HHEX, ISL1, SCGN, KCNK16, IAPP, FXYD2, NPTX2, GPC5-AS1, UCP2, LEPR, BAIAP3, MS4A8, CASR, BCHE, GABRB3, UNC5B, EDN3, PRG4, FRZB, PCSK1, GABRG2, POU3F1, BHLHE41, EHF, LCORL, ETV1 (sc-type)

○ (+) SST, RBP4, HHEX, ISL1, SCGN, IAPP, GPC5-AS1, PCSK1 (PanglaoDB)

⑤ 종류 5. pancreatic epsilon cell

○ (+) GHRL, ANXA13, PHGR1, BMP4, HMGCS2, TM4SF5, OLFML3, ASGR1, COX6A2, NPY1R, SLC7A9, BHMT, OPRK1, PTGER4, ITGA4, EYA4, XYLB, ELOVL2, AFF3, CORIN, MYO1A, HRH2, SLC6A16, PCSK6, ADAMTS6, COL22A1, FAM124A, COL12A1, CD109, THSD4, ARX (sc-type)

⑥ 종류 6. pancreatic gamma (PP) cell

○ (+) PPY, SCGN, FXYD2, SCGB2A1, GPC5-AS1, CMTM8, ARX, ETV1, PXK, SERTM1, SLITRK6, SEMA3E, APOBEC2, ABCC9, NEUROD1, PAX6, ISL1, CARTPT, THSD7A, AQP3, ENTPD2, PTGFR, CHN2, EGR3, LMO3, MEIS1, ZNF503 (sc-type)

○ (+) PPY, SCGN, SCGB2A1, GPC5-AS1, CMTM8, NEUROD1, AQP3 (PanglaoDB)

⑦ 종류 7. langerhans cell

○ (+) CD1A, Langerin (CD207), EpCAM, CD11c, RUNX3, ID2, AHR

○ (+) CD207, CCL22, DAPP1, C15orf48, TRAF1, NEDD4, HLA-DQA2, GNA15, GPR157, HLA-DQB2 (Tabula Sapiens)

○ (+) HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1 (PanglaoDB)

⑧ 종류 8. pancreatic A cell

○ (+) GCG, KCNK16, CRH, SLC30A8, CPLX2, NKX2-2, CRYBA2, CHGA, INSM1, RFX6 (Tabula Sapiens)

⑨ 종류 9. pancreatic D cell

○ (+) KCNK16, GCG, SST, CRH, AVPR1B, GAD2, GPC5-AS1, ACTL6B, CPLX2, RP5-984P4.6 (Tabula Sapiens)

⑩ 종류 10. pancreatic PP cell

○ (+) PPY, GPC5-AS1, GAD2, PAM, NKX2-2, CALB1, SLC30A8, ARX, SCG2, STMN2 (Tabula Sapiens)

⑪ 종류 11. type B pancreatic cell

○ (+) KCNK16, GAD2, G6PC2, IAPP, FAM159B, RP5-984P4.6, MIR7-3HG, NKX2-2, SLC30A8, CELF3 (Tabula Sapiens)

⑼ 조직 8. intestine stroma

① (+) TRAC, TRBC1

② 종류 1. enterocyte

○ (+) KRT20, PPARG, FABP1, ANPEP, CA1, FABP2, VIL1, CDH17, CDC42EP5, HNF4A, TMEM45B, ELF3, TMC4, PPP1R14D, CEACAM1, KLF5, CDX1, CDX2, PRR15L, MUC13, PHGR1, LGALS2, CD55, SLC26A2, SLC26A3, SLC51B, ABCG2, ACSL5, AQP8, SLC39A5, MAOA, DGAT1 (PanglaoDB)

○ 1-1. immature enterocyte

○ 1-2. mature enterocyte

○ (+) UGT2B17, LGALS4, FABP2, CHP2, CDX2, PPP1R14D, FABP1, CDH17, TSPAN8, CES2 (Tabula Sapiens)

○ 1-3. proximal enterocyte

③ 종류 2. crypt cell

○ 2-1. intestinal crypt stem cell

○ (+) TSPAN8, UGT2B17, SLC12A2, URAD, LEFTY1, ADH1C, RGMB, CDX2, LGALS4, CHP2 (Tabula Sapiens)

○ 2-2. intestinal crypt stem cell of large intestine

○ (+) RN7SK, RNU6ATAC, MAFA, HSPA2, HIST4H4, CSRNP2, HIST1H2AG, PARD6G-AS1, DLL4, MTMR11 (Tabula Sapiens)

○ 2-3. intestinal crypt stem cell of small intestine

○ (+) APOBEC1, CCL25, RBP2, CLDN15, MISP, SLC39A4, PRAP1, ARL14, RHPN2, AC021218.2 (Tabula Sapiens)

④ 종류 3. goblet cell

○ (+) Ido1

○ (+) MUC2, ITLN1, TFF3, AGR2, PHGR1, MUC13, FCGBP, ZG16, KLK1, SPINK4 (PanglaoDB)

○ 3-1. large intestine goblet cell

○ (+) MUC2, BEST2, CLCA1, ZG16, TFF3, ST6GALNAC1, REP15, FCGBP, HEPACAM2, WNK4 (Tabula Sapiens)

○ 3-2. small intestine goblet cell

○ (+) CLCA1, MUC2, ZG16, SPINK4, FER1L6, TFF3, ITLN1, SCNN1A, REG4, GALNT8 (Tabula Sapiens)

⑤ 종류 4. transit amplifying cell

○ 4-1. transit amplifying cell of large intestine

○ 4-2. transit amplifying cell of small intestine

○ (+) CCL25, RBP2, FABP2, MUC17, SLC5A1, CLDN15, PRAP1, OLFM4, CHP2, VIL1 (Tabula Sapiens)

○ 4-3. transit amplifying cell of colon

○ (+) NOX1, URAD, LEFTY1, UGT2B17, LGALS4, CDX1, CDX2, NXPE4, TSPAN8, PPP1R14D (Tabula Sapiens)

⑥ 종류 5. intestinal enteroendocrine cell

○ (+) NKX2-2, INSM1, MIR7-3HG, FEV, CHGA, RFX6, CRYBA2, RIMBP2, PCSK1N, SCG3 (Tabula Sapiens)

○ (+) SCGN, SST, GCG, CHGB, CPE, IAPP, CHGA (PanglaoDB)

⑦ 종류 6. intestinal tuft cell

○ (+) TRPM5, IL17RB, PLCG2, SH2D6, LY6H

○ (+) GNAT3, SH2D7, GNG13, CCDC129, TRPM5, LRMP, SH2D6, MATK, CCSER1, POU2F3 (Tabula Sapiens)

⑧ 종류 7. enteric glia cell

○ (+) GFRA3, MPZ, LGI4, RGS16, ALDH1A1, L1CAM, DKK3, INTS6, DHRS3, S100B (PanglaoDB)

⑨ 종류 8. enteric neuron

⑩ 종류 9. enterochromaffin cell

⑪ 종류 10. foveolar cell

⑫ 종류 11. gastric chief cell

⑬ 종류 12. microfold cell

⑭ 종류 13. paneth cell

⑮ 종류 14. parietal cell

⑯ 종류 15. telocyte

⑽ 조직 9. kidney stroma

① 종류 1. podocyte

○ (+) NPHS1, NPHS2, EZR, TDRD5, SEMA3G, SEMA5A, SEMA3E, PLA2R1, COL4A4, ARHGAP24, WT1, COL4A3, RHPN1, MAFB, PODXL, CLIC5, CD2AP, NOTCH2 (sc-type)

○ (+) PODXL, VEGFA, SYNPO, NPHS1, NPHS2, WT1, PTPRO, THSD7A, MAFB, ENPEP, CLIC5, BCAM, MAGI2, EFNB1, PLOD2, SRGAP1, TCF21, PTH1R, CTGF, TRIB2, DACH1, AIF1L, GOLIM4, TOB1 (PanglaoDB)

② 종류 2. cancer stem cell

○ (+) EPCAM

③ 종류 3. mesangial cell (신사구체간질 세포)

○ (+) PDGFRB, PDGFB, LAMA4, ITGA8, LGALS1, ARID5B, CCR7, FN1, GATA3, PAWR, SERPINE2, TBX18, TEK, THY1, REN, ZEB2 (sc-type)

○ (+) PDGFRB, ANGPT2, CTGF, GATA3, ITGA8, ARID5B, FN1, PTN, MYL9, TPM2, CALD1, HOPX, ACTN1, AKAP12, ROCK1, SH3BGRL, FILIP1L, FLNA, MEF2C, CSTB, MAP3K20 (PanglaoDB)

④ 종류 4. cap mesenchyme cell (mesenchymal cell)

○ (+) SIX2, ITGA8, NR2F2, EYA1, MEIS2, CITED1, MUC1, NOTCH2 (sc-type)

⑤ 종류 5. stromal cell

○ (+) MEIS1, TCF21, COL1A2, COL3A1, TNC, COL6A3, LGALS1 (sc-type)

⑥ 종류 6. juxtaglomerular cell

○ (+) REN, CRIP1 (sc-type)

⑦ 종류 7. renal interstitium (mesenchymal cell)

○ (+) SFRP1, MEIS1, PDGFRA, C7, MGP (sc-type)

⑧ 종류 8. cancer stem cell

○ (+) EPCAM (sc-type)

⑨ 종류 9. kidney progenitor cell

○ (+) PAX2, EYA1, WT1, CITED1 (PanglaoDB)

⑩ 종류 10. principal cell

⑪ 종류 11. transient cell

⑾ 조직 10. brain stroma

① 종류 1. 뉴런(neuron)

○ (+) ENO2, NEFM, SLC12A5, TMEM130, CLSTN3, ARID4A, RHBDD2, TMEM59L, MIAT, AAK1, SPOCK3, DNM3, DNER, CHN1, GABBR2, MEG3, BEX2, BEX1, CAMK2N1, PNISR, STMN2, SNAP25, VSNL1, ATP6V0A1, MYO5A, DYNC1I1, ELAVL3 (PanglaoDB)

○ (+) CAMKV, EPHA3, NEUROD6, SLC24A2, NELL1, GAP43, SOX11, ELAVL4, BEX1, RTN1, SNAP25, SYT1, ELAVL3, STMN2, STMN4 (SCEVAN)

○ 1-1. cholinergic neuron

○ (+) Slc18a3

○ (+) CHAT, SLC18A3, ACHE (sc-type)

○ 1-2. dopaminergic neuron

○ (+) Slc6a3

○ (+) TH, SLC6A3, FOXA2, KCNJ6, NR4A2, LMX1B, DBH, SLC6A2, PPP1R1B (sc-type)

○ 1-3. GABAergic neuron

○ (+) Slc32a1

○ (+) SLC6A1, GABBR1, GABBR2, GAD2, GAD1, SLC32A1 (sc-type)

○ 1-4. glutamatergic neuron

○ (+) Slc17a7, Slc17a6, Slc17a8

○ (+) SLC17A7, SLC17A6, GRIN1, GRIN2B, GLS, GLUL, GRIN2A (sc-type)

○ 1-5. serotonergic neuron

○ (+) Slc6a4

○ (+) TPH1, SLC6A4, FEV, HTR1A, HTR1B (sc-type)

○ (+) TPH1, FEV, DDC (PanglaoDB)

○ 1-6. adrenergic neuron

○ 1-7. glycinergic neuron

○ (+) Slc6a5

○ 1-8. noradrenergic neuron

○ (+) Slc6a2

○ 1-9. histaminergic neuron

○ (+) Hdc

○ 1-10. bipolar neuron

○ 1-11. immature neuron

○ (+) DCX, NEUROD1, TBR1, STMN1, NCAM1, TUBB3 (sc-type)

○ 1-12. mature neuron

○ (+) RBFOX3, MAP2, SYP, DLG4, TUBB3, MAPT, INA, GAP43, NRP1 (sc-type)

○ (+) TUJ1

○ 1-13. neural progenitor cell

○ (+) CSPG4, RNF5, EOMES, SOX2, SOX1, NES, PAX3, PAX6, OTX2, CNTNAP1, ASCL1, SMARCA4, MSI1, MSI2 (sc-type)

○ 1-14. neural stem cell

○ (+) SOX2, PROM1, NES, SOX9 (sc-type)

○ 1-15. interneuron

○ 1-15-1. interneuron progenitor

○ (+) Dlx1, Dlx2, Lhx6, Nkx2-1

○ 1-16. peripheral nerve

○ (+) MPZ, S100B, LGI4, PLP1

○ 1-17. motor neuron

○ 1-18. noradrenergic neuron

○ 1-19. Purkinje neuron

○ (+) Pcp4, Car8, Calb1, Slc1a3, Ppp1r17, Pvalb

○ 1-20. pyramidal cell

○ 1-21. trigerminal neuron

○ 1-22. granule neuron

○ (+) Snap25, Cbln3, Gabra6

○ 1-23. MSN(medium spiny neuron)

○ (+) Gpr88

○ 1-24. olfactory bulb

○ 영역 1. glomerular layer

○ (+) Eomes

○ 영역 2. mitral layer

○ (+) Eomes

○ 상태 1. inhibitory neuron

○ (+) Lamp5, Sncg, Vip, Sst, Pvalb

② 종류 2. glial cell (신경교세포)

○ 2-1. glioblasts

○ (+) Aldh1l1, Efna5, Wnt1, Wnt9a, Rspo1/2/3

○ 2-2. neuroblasts

○ (+) Npas3, Adgrb3, Fgf15, Wnt7b, Tnc

○ (+) NEUROD1, DCX, DLX2, PROX1, EOMES, TUBB3 (sc-type)

○ 2-3. radial glial cell

○ (+) Mki67, Dbx1, PAX6, HES1, HOPX

○ (+) VIM, NES, PAX6, HES1, HES5, GFAP, SLC1A3, FABP7, TNC, CDH2, SOX2 (sc-type)

○ (+) SOX15, RP11-54H7.4, FAM83A, LAMC2, BNC1, IRF6, ITGA2, DMRTA2, COL17A1, LAMA3 (Tabula Sapiens)

○ 2-4. Schwann cell

○ (+) UNC93B6, FOXD3, AC012470.1, DLX1, FOXD3-AS1, RP5-907C10.3, GDNF-AS1, SMIM41, PLP1, KLHDC8A

○ 2-4-1. myelinating Schwann cell

○ (+) SOX10, EGR2, MBP, MPZ (sc-type)

○ 2-4-2. non-myelinating Schwann cell

○ (+) SOX10, GAP43, NCAM1, NGFR (sc-type)

○ 2-4-3. Schwann precursor cell

○ (+) SOX10, GAP43, FABP7, MPZ, DHH, NGFR (sc-type)

○ 2-5. astrocyte

○ (+) Gfap, S100b

○ (+) GFAP, SLC1A3, SLC1A2, GLUL, S100B, ALDH1L1, AQP4, IGFBP3, ATP13A4, CBS, SOX9, CD40, CD80, CD86, C5AR1 (sc-type)

○ (+) S100B, SLC1A2, GFAP, SLC1A3, FGFR3, AQP4, AGT, GPR37L1, SLC6A11, SYNE1, PLXNB1, GJA1, APOE (PanglaoDB)

○ 2-6. oligodendrocyte (희소아교돌기세포)

○ (+) Mbp, Plp1, Mobp, Car2

○ (+) OLIG1, OLIG2, OLIG3, CLDN11, MBP, MOG, MAG, GALC, CNP, SOX10, FA2H, UGT8 (sc-type)

○ (+) MOG, TF, TMEM63A, PTGDS, MYRF, SEMA4D, GJB1, ERMN, CLDN11, ANLN, PLLP, PEX5L, ST18, MAG, ENPP2, PLP1, MBP (PanglaoDB)

○ (+) OLIG2, NKX2-2, SOX10, AACS, AARD, ABCA6, ABCA8, ABCB4, ABHD4, ABLIM2, ABTB2, AC023908.1, AC136616.1, ACAN, ACAP3 (SCEVAN)

○ 2-6-1. oligodendrocyte precursor cell (OPC, NG2)

○ (+) Ptprz1

○ (+) LHFPL3, MEGF11, PCDH15, PDGFRA, CSPG4, RNF5 (sc-type)

○ (+) PDGFRA, GPR37L1, VCAN, EPN2, OLIG1, TNR, CNP (PanglaoDB)

○ 2-6-2. myelinating oligodendrocyte

○ (+) GALC, GPR17, MYRF, CNP, HES5, IL1RAP, NKX2-2, MBP, CLDN11, PLP1UGT8, MOG, SOX10, ERMN, MAG, MOBP (SCEVAN)

○ (-) Ptprz1

○ 2-7. tanycyte

○ (+) GPR50, COL23A1 (sc-type)

○ 2-8. Bergmann glia

○ (+) Gfap

○ 2-9. Cajal-Retzius cell

○ 2-10. ganglion cell

○ 2-11. pinealocyte

○ 2-12. satellite glial cell

③ 종류 3. neuroendocrine cell

○ (+) Kcna1, Olfr558, Mpz, Casq2, Rgs5, Plp1, Pln, Sox10, Nrip2, Rgs4 (Tabula Muris)

⑿ 조직 11. lung stroma

① 종류 1. ciliated cell

○ (+) Dynlrb2, Foxj1

○ (+) APPL2, ATP5MD, CCDC153, CCDC17, CCDC181, CCDC39, CYP2S1, FAM161A, FOXJ1, LRRC23, ODF3B, SCGB1A1, SEC14L3, SNTN, STK11, TMEM212, TSPAN19, TUBB4B (sc-type)

○ (+) RP11-680N20.1, APOBEC4, RP11-60L3.6, RP11-122M14.1, EPPIN, DNAI1, AC009502.4, AC005281.1, LDLRAD1, SNTN (Tabula Sapiens)

○ (+) C20orf85, SNTN, ANKRD66, C11orf88, TMEM190, FAM216B, SRGAP3-AS2, STOML3, PIH1D3, C1orf194 (Tabula Sapiens)

○ 1-1. airway ciliated cell

② 종류 2. airway goblet cell

○ (+) AGR2, AQP5, CEACAM1, DMBT1, DUSP4, FXYD3, GALNT5, GALNT6, GGH, GOLPH3, GP2, IL19, LIPF, LTF, LYNX1, MSLN, MUC16, MUC4, MUC5B, NOS2, PIGR, QSOX1, SCGB3A1, SEC23B, SPDEF, TFF2 (sc-type)

③ 종류 3. hair follicle cells

○ (+) Krt5, Krt17

④ 종류 4. ionocyte (chloride cell) : mitochondrion-rich cell

○ (+) GPRC6A, ASCL3, FOXI1, BSND, FOXI2, LCNKB, TMPRSS11E, ATP6V0A4, TMEM61, ATP6V1C2 (Tabula Sapiens)

⑤ 종류 5. neuron

⑥ 종류 6. pulmonary ionocyte

○ (+) DMRT2

○ (+) CFTR, CLCNKB, FOXI1, KCNMA1, SCGB1A1, SLC12A2, TFCP2L1 (sc-type)

○ (+) CLDN25, ATP6V1G3, LINC00706, ASCL3, LINC01187, DDX4, CYP26A1, STAP1, SP9, BSND (Tabula Sapiens)

⑦ 종류 7. respiratory goblet cell

○ (+) SCGB1A1, BPIFB1, SCGB3A1, CYP2F1, VMO1, MUC5B, CXCL6, MSMB, CCNO, CYP2J2 (Tabula Sapiens)

⑧ 종류 8. respiratory mucous cell

⑨ 종류 9. pericyte

⑩ 종류 10. fibroblast

○ (+) COL3A1, COL5A2, DPT, FN1, GSN, LRP1, PDGFRA, TCF21 (sc-type)

○ 10-1. adventitial fibroblast : pericyte의 특수한 서브타입

○ 10-2. alveolar fibroblast

○ 10-3. intermediate pathological fibroblast

○ 10-4. mesothelial fibroblast

○ 10-5. pathological fibroblast

⑪ 종류 11. basal cell (airway progenitor cell)

○ (+) ABI3BP, AQP3, DAPL1, GSTM2, HPGD, ICAM1, KRT14, KRT15, KRT5, PHLDA3, RPS18, SDC1 (sc-type)

○ 11-1. airway basal cell

⑫ 종류 12. clara cell

○ (+) AHR, ALDH1A1, BPIFA1, CTSE, CYP2E1, CYP4B1, ERN1, FOXM1, LEPR, MUC1, MUC4, MUC5B, RAB3D, SCGB1A1, SCGB3A1, SCGB3A2, SFTPA1, SFTPC, SFTPD, SYT2 (sc-type)

○ (+) SCGB1A1, SCGB3A2, SFTPC, MUC1, CYP4B1, SCGB3A1, SFTPA1 (PanglaoDB)

⑬ 종류 13. secretory cell

○ (+) MUC5B, PIGR, SCGB1A1 (sc-type)

⑭ 종류 14. airway mucous cell

⑮ 종류 15. airway smooth muscle

○ 15-1. airway smooth muscle

○ 15-2. vascular smooth muscle

⑯ 종류 16. cancer stem cell

○ (+) ABCG2, ALCAM, ALDH1A1, BMI1, CD24, CD44, KIT, NANOG, NES, PDPN, POU5F1, PROM1, SOX2, THY1 (sc-type)

⑰ 종류 17. adventitial cell : pericyte의 특수한 서브타입

○ (+) TSKU, GFPT2, MFAP4, PCOLCE, SPOCK1, GPR133, PI16, GFRA1, FIBIN, PDGFRL (Tabula Sapiens)

⒀ 조직 12. adrenal stroma

① 종류 1. CSH1_CSH2 positive cell

○ (+) CGB, GH2, PSG5, CGA, CSH1, ERVW-1, CSH2, PSG7, PSG11, HSD3B1, PSG9, PSG1, PSG6, PLAC4, PSG4 (sc-type)

② 종류 2. megakaryocyte

○ (+) C15orf54, GP9, PF4, PPBP, GP1BA, MEGT1, LY6G6F, GP6, ITGA2B, C6orf25, ALOX12, FCER1A, ELOVL7, NRGN, RP11-930O11.1 (sc-type)

③ 종류 3. Schwann cell

○ (+) WNT16, MPZ, FOXD3, SOX10, CDH19, GPR17, PMP2, COL20A1, INSC, RP4-792G4.2, TTYH1, SOX2, LAMP5, OLFML2A, ATP1A2 (sc-type)

④ 종류 4. sympathoblast

○ (+) NPAS4, SLC24A2, RP11-542G1.2, PENK, LINC00890, KLK4, RP11-17A4.2, RP5-1096J16.1, C18orf42, TTC40, ARC, FAM19A3, VWA5B1, PPP1R17, RP4-718N17.2 (sc-type)

⑤ 종류 5. stromal cell

○ (+) MIR1245A, NPY5R, RP11-60A8.1, RP11-254F19.2, RP11-494K3.2, RP11-758M4.4, RP11-142A23.1, RP11-752L20.5, OSR1, RP11-867G23.13, SULT1E1, HHIP, MGP, PRELP, TWIST2 (sc-type)

⑥ 종류 6. chromaffin cell

○ (+) NRG1-IT3, RNU6-457P, LINC00594, AC018643.4, RP11-159N11.3, CTC-537E7.1, Y_RNA, snoU13, CTD-2006K23.2, RP5-955M13.4, INSRR, KCNK10, PHEX-AS1, RP11-958J22.1, FLJ30594 (sc-type)

⑦ 종류 7. adrenocortical cell

○ (+) RP1-145M24.1, RP11-238I10.1, AC005392.13, RP11-316I3.2, RP11-501O2.4, SDIM1, RP11-258O13.1, AJ006998.2, CTD-2517O10.5, RNU6-944P, CTB-43E15.4, RP11-34F13.3, RP11-536K7.5, RP11-183M13.1, RNU6-56P (sc-type)

⑧ 종류 8. SLC26A4_PAEP positive cell

○ (+) IL1A, SLC26A4, SNX25P1, VMO1, CTD-2210P15.2, CTC-360P9.4, ULK4P1, SNORA14A, RNU6-518P, RP11-431N15.2, RP11-26J3.3, RP11-378A12.1, SPINK8, HSD3B2, KIRREL-IT1 (sc-type)

⒁ 조직 13. heart stroma

① megakaryocyte

○ (+) MEGT1, LY6G6F, TUBB1, PPBP, PF4, GP9, TPSB2, HBD, AC137932.6, ITGA2B, GP1BA, CLEC1B, PTCRA, BEND2, RP11-179A10.1 (sc-type)

② epicardial fat cell

○ (+) RP11-89M22.3, CTD-3012A18.1, PRG4, KRT7, SPRR2F, KLK11, MKRN9P, UPK1B, EPGN, NPHS1, ITLN1, LRRN4, CST6, GSDMA, RAET1E (sc-type)

③ Schwann cell

○ (+) GFRA3, SOX10, MPZ, LINC00466, COL20A1, MIA, ASPA, ERBB3, TFAP2A, INSC, ARTN, PMP2, S100B, FOXD3, AP000797.3 (sc-type)

④ endocardial cell

○ (+) ANGPTL5, APCDD1L, NPPC, SLC6A4, SALL1, LEPR, C3orf36, AC004562.1, FAM3D, HAPLN1, APCDD1, LYPD2, FOXC1, MPZL2, RP11-849I19.1 (sc-type)

⑤ stromal cell

○ (+) RP11-60A8.1, SCARA5, DPT, CILP, ZCCHC5, AGTR2, MFAP5, RP11-71N10.1, LUM, ABCA10, RP11-31K23.2, CCL11, NRK, PDGFRA, LPAR4 (sc-type)

⑥ smooth muscle cell

○ (+) PDE4C, RP11-112H10.4, RP11-598F7.5, RP11-626H12.1, HCG22, CTD-3064M3.3, RP11-231I13.2, GPR20, RP11-267N12.1, OR51E1, THBS4, MIR143HG, PDGFRB, AOC3, ENPEP (sc-type)

⑦ SATB2_LRRC7 positive cell

○ (+) NEUROD2, FEZF2, NEUROD6, TBR1, MPPED1, SATB2, FOXG1, PCDH11Y, CAMKV, BHLHE22, SLIT1, C14orf23, RP11-562L8.1, LINC00966, DRAXIN (sc-type)

⑧ visceral neuron

○ (+) GATA3-AS1, GAL, CHRNA3, PRPH, PHOX2A, GALR1, NXPH1, TMC3, DDC, SST, OPRM1, PIRT, NECAB2, ECEL1, SLC10A4 (sc-type)

⑨ cardiomyocyte

○ (+) Myh6, Myh7, Tnnc1

○ (+) MYH6, TECRL, COL2A1, AC020909.2, NKX2-5, FBN2, TNNT2, MYL4, MYL7, ACTC1 (Tabula Sapiens)

○ (+) RP11-439H8.4, RNA5SP327, CTD-2552K11.2, Y_RNA, AC018464.3, HHATL, BMP10, RP11-461A8.4, UGT2B4, PRSS42, WI2-1896O14.1, FABP2, EPN3, RP11-406O23.2, AC009878.2 (sc-type)

⑩ ELF3_AGBL2 positive cell

○ (+) C1orf194, ZMYND10, MS4A8, IL20RA, ELF3, SCGB3A2, EFCAB1, SFTPB, WDR65, CP, PIH1D2, AGBL2, SFTPC, DNAH9, MUC1 (sc-type)

⑪ CLC_IL5RA positive cell

○ (+) FAM209A, CERKL, CLC, PRG2, MS4A3, IL5RA, ZC2HC1C, CTD-2620I22.1, CTD-3032H12.2, RP11-252E2.1, AC011524.1, S100A1, Y_RNA, LINC00407, RP11-516C1.1 (sc-type)

⑫ cardiac stem and precursor cell

⑬ his bundle cell

⑭ Purkinje fiber cell

⑮ Cajal cell

⒂ 조직 14. intestine stroma

① chromaffin cell

○ (+) ARX, NKX2-2, CCK, CRYBA2, NEUROD1, FEV, MLN, ASIC5, ONECUT3, SST, RP11-788H18.1, PAX4, KCNH6, SSTR5, PCSK1 (sc-type)

② smooth muscle cell

○ (+) ACTG2, GREM2, CNN1, RP11-467I20.6, WIF1, TACR2, OVCH2, FRMD6-AS2, DES, MYH11, RP11-626H12.1, ANO1, CHRDL2, TAGLN, FBXL22 (sc-type)

③ ENS glia

○ (+) SERPINA3, RLBP1, GPR12, RP4-792G4.2, CDH19, COL20A1, SOX10, PLP1, SOX2, FOXD3, MPZ, BCAN, TFAP2A, SOX2-OT, PTPRZ1 (sc-type)

④ ENS neuron

○ (+) PDIA2, RP11-672L10.2, GRP, DRGX, GCGR, SLC18A3, PHOX2A, HECW1-IT1, RP11-202H2.1, IQCJ, STMN4, TTC9B, GAL, CEND1, NEFL (sc-type)

⑤ stromal cell

○ (+) RP11-13P5.2, MSC, RP1-283K11.3, RP5-1077H22.1, CTD-2541J13.1, AC002511.2, AC002511.3, MMP27, CTD-2334D19.1, CXCL14, FZD10, PDGFRA, AC003090.1, RP1-288H2.4, ITGA11 (sc-type)

⒃ 조직 15. placenta stroma

① PAEP_MECOM positive cell

○ (+) RP11-98L5.2, AC104654.1, PAEP, RP11-274B18.4, PIGR, TSPAN1, AC012593.1, RP11-510D19.1, POU5F1, UGT2B7, DEFB1, RP11-697E22.2, SLC18A2, PAX8, SLPI (sc-type)

② AFP_ALB positive cell

○ (+) SLC2A2, ALB, APOB, AFP, ITIH2, F2, MAT1A, APOC3, SERPINC1, FABP1, APOA2, AHSG, SERPINA10, SLC38A3, SERPINA4 (sc-type)

③ extravillous trophoblast

○ (+) AC022596.6, GKN1, CILP2, LINC00330, PDE6H, PRG2, RP11-872D17.8, HLA-G, ASCL2, NOTUM, AC006262.5, DAW1, NOG, TAC3, RP11-420L9.4 (sc-type)

④ trophoblast giant cell

○ (+) CCK, CTA-833B7.2, PSG1, CGB, CSH2, PSG6, KISS1, INHBA, GH2, PSG9, CRH, PSG8, RP11-76E12.1, PSG4, TREML3P (sc-type)

⑤ smooth muscle cell

○ (+) RP11-162G9.1, FAM162B, WNT3A, AFF2, CDH19, SCN11A, GPR20, COX4I2, AGTR1, ADAMTS20, RP11-123O22.1, HIGD1B, AC020571.3, COLEC10, KCNK17 (sc-type)

⑥ IGFBP1_DKK1 positive cell

○ (+) RP3-404K8.2, RP11-486P11.1, FOXL2, WT1, RP11-171A24.3, SCARA5, LRRN4CL, S100A3, WT1-AS, PRL, WNT4, AC012065.7, APOD, BRINP2, RORB (sc-type)

⑦ stromal cell

○ (+) AP006285.6, AC002451.1, RP11-99L13.2, RP1-79C4.4, MMP23B, RP11-248N22.2, LA16c-380H5.4, MIR218-1, C8orf87, SNORD113, RP11-74M11.2, HSD3BP2, AP001605.4, LINC00314, AC007394.3 (sc-type)

⑧ syncytiotrophoblasts and villous cytotrophoblast

○ (+) CTD-2050E21.1, POTEKP, RP11-344B2.3, RP11-366M4.3, RP11-2A4.4, RP11-483F11.7, FTLP14, RP11-718G2.5, RP11-18D7.3, CLCA2, KB-1440D3.13, CTBP2P8, RP11-359P18.1, HSPD1P6, AC124861.1 (sc-type)

⑨ megakaryocyte

○ (+) EGF, TUBB1, PPBP, ITGA2B, RP11-930O11.1, RP11-152K4.2, LINC00989, PF4, C6orf25, LINC00534, PKHD1L1, NRGN, DNM3, RP11-466L17.1, RP11-142C4.6 (sc-type)

⒄ 조직 16. spleen stroma

① AFP_ALB positive cell

○ (+) SERPINA6, PLG, AMBP, SERPINC1, BHMT2, LBP, PRAP1, APOB, SERPINA1, FGB, VTN, SLC2A2, FGG, MT1G, ITIH1 (sc-type)

② stromal cell

○ (+) CTD-2270F17.1, ENPP7P4, AC105053.3, RP11-388K12.1, SCTR, KBTBD11-OT1, ADRA1B, NPM1P10, NPY5R, TPH2, CTC-535M15.2, MIR143HG, KLHL29, AC023481.1, CADPS (sc-type)

③ STC2_TLX1 positive cell

○ (+) CAMK2N2, CLVS2, RP11-384O8.1, FBXL16, GABRG2, HRK, EBF3, TRH, AC018730.1, CTD-3193O13.9, CPLX2, ATP1A3, TMEM119, IFI27L2, PET117 (sc-type)

④ megakaryocyte

○ (+) RAB27B, RP11-556I14.2, EGF, GP6, RP11-930O11.1, LINC00989, SELP, GP1BA, HPSE, RP11-152K4.2, LINC00504, MMRN1, ITGB3, ELOVL7, LY6G6F (sc-type)

⒅ 조직 17. stomach stroma

① neuroendocrine cell

○ (+) SLC18A1, GHRL, GAST, FEV, NKX2-2, CRYBA2, MBOAT4, CDK5R2, RFX6, HAP1, RP11-82C23.2, RBPJL, PTF1A, PAX6, CACNA1A (sc-type)

② parietal and chief cell

○ (+) RP11-467I20.6, ETNPPL, ATP4B, FGB, FGA, SIGLEC11, FRMD1, TRIM50, ALB, ATP4A, ANGPTL3, MFSD4, APOBEC2, CKM, PAQR5 (sc-type)

③ MUC13_DMBT1 positive cell

○ (+) ISX, GUCA2B, ENPP7, MIR194-2, BTNL3, TM4SF20, SI, SLC17A4, ALDOB, CDX1, DMBT1, CHP2, KRT20, SLC5A12, ADRA2A (sc-type)

④ goblet cell

○ (+) UGT2B15, IL17C, GKN2, SLC22A8, CXCL5, CSF3, TFF2, A4GNT, FBP2, FGF20, MUC6, GKN1, CXCL1, MUC5AC, CA9 (sc-type)

⑤ stromal cell

○ (+) AC002511.2, PTGER1, OSR2, AC003090.1, ACTG2, INHBA, HSPB6, AC131025.8, SHISA3, DPT, TRPA1, ACTA2, TWIST2, CXCL14, GLIS1 (sc-type)

⑥ ENS neuron

○ (+) PRPH, STMN2, ATP1A3, KCNIP4, NKAIN1, INA, GAP43, ATCAY, CNGB1, TCEAL5, STAC, DCX, RP11-457K10.1, FAM163A, CNTN5 (sc-type)

⑦ ENS glia

○ (+) SOX10, MPZ, ATP1A2, BAI1, PLP1, CDH19, COL20A1, ELOVL2, NOV, PRIMA1, RP11-308N19.1, SLC35F1, LGI4, VGLL3, EGFLAM (sc-type)

⑧ PDE1C_ACSM3 positive cell

○ (+) RP11-690G19.4, ACSM3, C1orf95, KCNE4, PDE1C, PSEN2, ERBB4, ATP6V0A4, TFCP2L1, WNK3, GABRB2, ADARB2, AMACR, SHISA2, NOX4 (sc-type)

⒆ 조직 18. thymus stroma (thyroid stroma)

① stromal cell

○ (+) PLAC9, LOX, MGP, COL1A2, COL5A3, COL1A1, ASPN, FGF18, MMP2, ISLR, DCN, SFRP2, COL3A1, SCARA5, COL6A6 (sc-type)

② thymocyte

○ (+) RP11-104L21.3, BEST3, HKDC1, KLRC4-KLRK1, RP11-305P22.9, LTA, TMSB15B, RP11-739G5.1, UBASH3A, PLK4, FBXO41, LIN28B, SKA3, CD40LG, AC002454.1 (sc-type)

○ (+) C1orf228, VIPR2, SLAMF1, CCR9, CHRM3-AS2, SMC4, LEF1, ARRDC2, BACH2, SCML1 (Tabula Sapiens)

③ follicular cell

⒇ 조직 19. bladder stroma

① fibroblast

② myofibroblast cell

③ pericyte

④ smooth muscle cell

⒇ 조직 20. reproductive system (e.g., prostate)

① decidual cell

○ (+) XCL1, IGFBP1, XCL2, CTSW, IL32, TRDC, KLRC1, PRL, AREG (PanglaoDB)

② germ cell

○ (+) DDX4, PRM1, ODF2, CRISP2, TCP11, PHF7, SPINK2, TSACC, PGK2, GTSF1, LELP1, MAEL, CCDC91, COX8C, FAM71E1, SPATA33, HMGB4, ROPN1L, TNP1, SMCP, LDHC, PRM2, DKKL1, MLF1, NR6A1, RSBN1L, DYNLT1, MRPL14, CREM (PanglaoDB)

③ granulosa cell

○ (+) AMH, INHA, TNNI3 (PanglaoDB)

④ Leydig cell

○ (+) INHA, DHCR7, CALB2, CYP17A1, CYP11A1, INSL3, LHCGR, STAR, PTGDS, HSD17B3, SMOC2, GJA1 (PanglaoDB)

⑤ Luteal cell

⑥ peritubular myoid cell

○ (+) SAT2, GSTM3, RNASE1, OSR2, MYL9 (PanglaoDB)

⑦ Sertoli cell

⑧ spermatocyte

○ (+) PRM1, PRM2, TNP1 (PanglaoDB)

⑨ spermatozoa

6. 유형 5. 기타 [목차]

⑴ embryo

① 종류 1. epiblast cell

② 종류 2. hemangioblast

③ 종류 3. trophoblast cell

④ 종류 4. trophoblast progenitor cell

⑤ 종류 5. trophoblast stem cell

⑥ 종류 6. embryonic stem cell (zygote)

⑵ 상태 1. EMT(epithelial-to-mesenchymal transition) : 전이의 주된 메커니즘

① (+) GATA3, TWIST2, SNAI2

② (-) DEFB4A, LCN2

⑶ 상태 2. MET(mesenchymal-to-epithelial transition)

⑷ 상태 3. EndMT(endothelial-to-mesenchymal transition)

⑸ 상태 4. MMT(mesothelial-to-mesenchymal transition)

⑹ 상태 5. MMT(monocyte-to-myofibroblast trans-differentiation)

입력: 2020.02.06 00:43

수정: 2023.08.27 00:48

저작자표시

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