셀 타입 마커 유전자(cell type marker genes)
추천글 : 【생물정보학】 생물정보학 분석 목차
1. 개요 [본문]
2. 유형 1. 상피세포 [본문]
3. 유형 2. 내피세포 [본문]
4. 유형 3. 면역세포 [본문]
5. 유형 4. 기질세포 [본문]
5. 유형 5. 기타 [본문]
a. 유전자 라이브러리
1. 개요 [목차]
⑴ 인간의 몸은 400 종류 이상의 세포로 구성
⑵ 유전자를 지칭할 때는 이탤릭체로 표현하고, 유전자의 단백질 산물을 표현할 때에는 정자체로 표현함
① 단, 여기에서는 정자체로 통일하기로 함
⑶ Homo sapiens (human)
① 유전자는 전부 대문자
② GRCh38 레퍼런스 기준 36601개 (ENSG)
⑷ Mus musculus (mouse)
① 유전자 첫 글자만 대문자이고 나머지는 소문자
② mm10 레퍼런스 기준 32285개 (ENSMUSG)
⑹ 실제로는 단순히 발현이 높은 것(high)과 발현이 설령 낮더라도 exclusive하게 발현하는 것(+)을 구분하는 게 일반적
⑺ 자료 1. Tabula Sapiens : 기본적으로 다음 셀 타입 리스트는 Tabula Sapiens를 기반으로 함 (file)
Figure. 1. Tabula Sapiens
⑻ 자료 2. Tabula Muris (ref, file)
⑼ 자료 3. Tabula Microcebus (file)
⑽ 자료 4. 아래 마커 유전자에서 실제 데이터에 적용할 때 사용할 마커 유전자를 추출하는 방법은 sc-type 알고리즘을 참고 (file)
⒀ 자료 7. 조직별 상대적 셀 분포 (file)
⒁ 자료 8. CellMarker 2.0 (file)
⒂ 자료 9. HCA (Human Cell Atlas)
⒄ 자료 11. cellxgene 데이터베이스 : CL:0001061과 같은 정보는 다음 파일 혹은 링크에서 확인 가능
⒅ 자료 12. 기타 부족한 정보는 수십억 개의 논문을 큐레이션 한 https://typeset.io/, https://www.scinapse.io/를 참고할 수 있음
2. 유형 1. epithelial cell (상피세포) [목차]
⑴ 개요 : pan-epithelial cell
① (+) EPCAM, KRT19, Epcam, Krt8, ANKRD30A, MUC6, MYBPC1
② (+) PATE4, SEMG1, PRPS2, SEMG2, ENPP3, FADS2, GSTM3, ABCG2, ELF5, PNMT (Tabula Sapiens)
③ (+) 4833423E24Rik, Krt33b, Cryba2, Bnc1, Krtap3-2, Sox21, Nmu, Gabrp, Clca4, Krt75 (Tabula Muris)
④ (+) CD24, CEACAM1, AGR2, GPA33, CEACAM5, SFN, TSTD1, PIGR, MUC13, SELENBP1, ELF3, TSPAN1, GUCA2A, PHGR1, LGALS4, TSPAN8, VSIG2, EPCAM (PanglaoDB)
⑵ adrenal cortex epithelium
① 종류 1. zona glomerulosa epithelial cell
○ (+) Akr1b7, Star
⑶ basal cell
① (+) KRT5, KRT14, KRT19, TP63
② (+) PTPRZ1, TP63, DSC3, KRT14, S100A2, CLCA2, MIR205HG, KRT15, EXPH5, DENND2C (Tabula Sapiens)
③ (+) KRT5, KRT17, ANXA11, PLAU, SRSF4, KRT23, ITGA2, RAB13, LAMB3, ACADVL, HEBP2, KRT15, PLP2, MT1X, S100A14 (PanglaoDB)
⑷ brain epithelium
① 종류 1. brain cancer cell epithelium
○ (+) CD44, MBTPS2, PARP1 (sc-type)
② 종류 2. brain cancer stem cell
○ (+) FUT4, MSI1, NES, PROM1, SOX2, THY1 (sc-type)
③ 종류 3. choroid plexus cell
○ (+) Clic6
④ 종류 4. anterior pituitary gland cell
⑤ 종류 5. ependymal cell
○ (+) Ccdc153
○ (+) FOXJ1, ENKUR, FAM216B, DNAH12, IQCG, SPEF2, ODF3B, TEKT1, LRRC23, PIFO, DYNLRB2, RSPH1, CCDC153, ZMYND10, CFAP44 (PanglaoDB)
⑥ 종류 6. meningeal cell
⑦ 종류 7. tancyte
⑧ 종류 8. brain layer
○ 8-1. white matter
○ (+) MOBP
○ 8-2. gray matter
○ (+) SNAP25
○ 8-3. L6
○ (+) KRT17
○ 8-4. L5
○ (+) PCP4
○ 8-5. L4
○ (+) RORB
○ 8-6. L3
○ (+) RORB, CUX2, HPCAL1
○ 8-7. L2
○ (+) RORB, CUX2
○ 8-8. L1
○ (+) RELN
⑸ cancer epithelium
① (+) CD44, EPCAM, ERBB2, FOLH1, KRT18, PROM1, KIT, CLDN4
② CCRCC(clear cell renal cell carcinoma)
③ ovarian cancer
④ endometrial cancer
⑤ B16F10
○ (+) DCT, PMEL, TYRP1, MLANA
⑥ EMT6
○ (+) RBP1, CRABP2
⑦ LL2
○ (+) RPL29, KRT18
⑧ CT26
○ (+) BAIAP2L1, RPL39L
⑨ MC38
○ (+) FAM159B, SNHG9
⑩ SA1N
○ (+) ITIH3
⑪ brain cancer cell epithelium
○ (+) CD44, MBTPS2, PARP1 (sc-type)
⑫ brain cancer stem cell
○ (+) FUT4, MSI1, NES, PROM1, SOX2, THY1 (sc-type)
⑬ breast cancer epithelium
○ (+) ABCC11, APOBEC3B, AR, CAV1, CCND1, CDH1, CEACAM6, CENPF, CXCL12, EGFR, ERBB2, ESR1, FOXA1, GATA3, KIT, KRT7, LDHB, LRRC15, MDM2, MKI67, PCLAF, PGR, PTGDS, RUNX1, S100A4, SCD, SFRP1, SNAI1, TACSTD2, TCF4, TOP2A, ZEB1, ZEB2
⑹ ciliated epithelial cell
① (+) FOXJ1, PAEP, UCA1, SCGB1D2, RP11-519G16.5, DCDC2, C2orf88, LAMC2, SCGB2A1, OCLN (Tabula Sapiens)
⑺ connective tissue cell
① (+) ADAMTS5, COL5A2, GPSM2, ITGBL1, TNXB, GPR133, CHRDL1, NBL1, SEMA3C, ELN (Tabula Sapiens)
⑻ eye epithelium
① 종류 1. corneal epithelial cell
○ (+) KRT3, KLF6 (sc-type)
○ (+) KRT12, MUC22, MGARP, CTSV, ERICH5, RP11-96L14.7, CRTAC1, KRT3, RAET1L, CREG2 (Tabula Sapiens)
② 종류 2. corneal keratocyte
○ (+) LEPR, LCN1, LACRT, FOXL2, NTRK2, OGN, BOC, CHRDL1, OMD, NECAB1 (Tabula Sapiens)
③ 종류 3. 광수용기 세포(photoreceptor cell)
○ (+) RBP3, RS1, KCNV2, IMPG1, RDH8, RTBDN, RP11-442N1.1, PDC, CPLX4, RP11-6E9.5 (Tabula Sapiens)
○ 3-1. rod photoreceptor cell
○ (+) Rho, Pdc, NRL, ROM1, CRX, ARR3, CABP4, CACNA1D, DYNLRB2, EDN2, FRMPD2, GJD2, KCNQ5, KCNA4, LRIT1, LRIT2, MAF, MED1, RORB, RP1L1, TSPAN10, TTC8, Gcap2, Samd7, Cerkl, SAMD11, SLC24A1, RP1, PDE6B (sc-type)
○ 3-2. cone photoreceptor cell
○ (+) Arr3, Opn1sw, NRL, ROM1, CRX, ARR3, OPN1LW, OPN1MW, CABP4, CACNA1D, EDN2, GJD2, GNB3, KCNQ5, LRIT1, MED1, RP1L1, THRB, TSPAN10, TTC8, Opmw, SLC24A1, RP1, PDE6B (sc-type)
④ 종류 4. ocular surface cell
⑤ 종류 5. retinal pigment epithelial cell
○ (+) EZR, RPE65, BEST1, ANO2, BMP2, BMP4, CLU, EFEMP1, IL4, KCNJ5, MED1, RDH5, RGR, SBSPON, TGFBR1, TMEM98, TTC8, TRAF1, Cerkl (sc-type)
○ (+) AC067969.2, RPE65, ITGAV, LINC00276, TMEM98, BEST1, FHIT, RBP1, RLBP1, ITGB8 (Tabula Sapiens)
⑥ 종류 6. cancer cell
○ (+) EPCAM (sc-type)
⑦ 종류 7. uveal tract cell
⑧ 종류 8. Schwalbe line cell
⑼ gland
① 종류 1. acinar cell of salivary gland
○ (+) BPIFA2, LPO, PRB2, CA6, PRB1, MUCL1, PRH1, PRB4, PRH2, HTN1 (Tabula Sapiens)
② 종류 2. duct epithelial cell
○ (+) TFCP2L1, ANKRD36C, FOLR1, SCGB3A1, CALML5, DMBT1, LRRC26, AZGP1, CCL28, TCN1 (Tabula Sapiens)
③ 종류 3. duodenum glandular cell
○ (+) TFF2, LIPF, C6orf58, GOLM1, A4GNT, KCNE2, FUT9, PGC, AGR2, SCG5 (Tabula Sapiens)
④ 종류 4. epithelial cell of lacrimal sac
○ (+) SMR3A, PROL1, DCT, LCN1, LINC01474, LACRT, ANGPTL7, KRT12, RP11-54H7.4, PLCB4 (Tabula Sapiens)
⑤ 종류 5. lacrimal gland functional unit cell
⑥ 종류 6. luminal epithelial cell of mammary gland
○ (+) SERPINA3, EGLN3, PRSS8, ANGPTL4, HILPDA, ITGB6, RP5-857K21.6, EFHD1, SERINC2, DSG2 (Tabula Sapiens)
○ (+) KRT18, SLPI, KRT19, CD74, AGR2, SERPINB3, WFDC2, LCN2, BTG1, CLDN4, ANXA1, HMGA1, TNFSF10, HIF1A, CEBPD, KRT8, CD9, AQP3, CDH1, MUC1 (PanglaoDB)
⑦ 종류 7. mucus secreting cell
○ (+) MUC5AC, BPIFA1, MUC5B, ANKRD36C, BPIFB1, LINC00342, SLC5A8, MUC4, SLC26A4, TMC5 (Tabula Sapiens)
⑧ 종류 8. salivary gland cell
○ (+) Gstm1, Wfdc18
○ (+) CENPF, NEK2, DEPDC1, TOP2A, MKI67, ANLN, IQGAP3, HMMR, MUC7, KLK5 (Tabula Sapiens)
⑨ 종류 9. secretory cell
○ (+) ATP12A, MUC4, SERPINB3, CXCL17, TSPAN1, MUC16, VMO1, ALOX15, CEACAM5, MAL2
⑩ 종류 10. stratified squamous epithelium from the oral mucosa
○ (+) Krt5, Krt15
⑪ 종류 11. mammary epithelial cell
○ (+) SERPINB5, KRT5, CLDN4, KRT17, NEDD9, KRT19, KRT7, KRT8, KRT18 (PanglaoDB)
⑫ 종류 12. parathyroid gland
○ 12-1. oxyphil cell
○ 12-2. parathyroid chief cell
⑬ 종류 13. breast glandular cell
○ (+) ADAM9, AGR3, ALDH1A3, AQP3, BACE2, C15orf48, C5orf46, CCDC6, CD9, CDC42EP1, CLIC6, CTTN, DAPK3, DMKN, DNTTIP1, DSC2, EIF4EBP1, ENAH, FASN, FLNB, HMGA1, HOOK2, HPX, JUP, KRT23, LYPD3, MLPH, MYO5B, OCIAD2, OPRPN, PIGR, PTRHD1, QARS, S100A14, SCGB2A1, SDC4, SERHL2, SERPINA3, SH3YL1, SLC25A37, SLC5A6, SMS, SQLE, SRPK1, SVIL, TCIM, TMEM147, TOMM7, TPD52, TRAPPC3, USP53, ZNF562
⑽ hepatic epithelium
① 종류 1. 담관세포(cholangiocyte) : 담즙의 통로
○ (+) SSTR2, SLC4A2, KRT7, KCNN2, ITGB4, GGT6, CFTR, AQP4, AQP1, PIGR, GGT1, JAG1, GPBAR1, GGT7, KRT19, ONECUT2, ALPL, HNF1B, ALB, AGR2, TFF3, TFF1, SOX9, EPCAM, CLDN4, MMP7, TFF2, SCGB3A1, FXYD2, DEFB1, CD24, LCN2, CXCL1, CXCL6, LGALS2, TACSTD2, ELF3, SPP1, MUC5B, LGALS4, KRT8 (sc-type)
○ (+) CHST4, FGFR2, GC, TM4SF4, APCS, AMBP, AGT, SLC17A4, SEMA3E, CXCL6 (Tabula Sapiens)
○ (+) PIGR, KRT19, AGR2, TFF3, EPCAM, CLDN4, CD24, LCN2, ELF3, LGALS4 (PanglaoDB)
② 종류 2. cancer stem cell
○ (+) ANPEP, CD44, EPCAM, POU5F1, PROM1, THY1
⑾ intestinal epithelial cell
① (+) UNC5CL, C1orf177, TRIM31, LINC00955, RP3-417L20.4, HMGN1P20, ALPI, RP11-395B7.2, EGFR-AS1, RP11-462G2.1, DEFB1, CA7, RP11-468N14.13, ARL14, AC024592.9 (sc-type)
② 종류 1. enterocyte of epithelium of large intestine
○ (+) 2610528A11Rik
○ (+) MUC12, NXPE1, CLDN3, PHGR1, CDX1, MUC13, RP11-357H14.17, FXYD3, LGALS4, CDH17 (Tabula Sapiens)
③ 종류 2. enterocyte of epithelium of small intestine
○ (+) RBP2, CCL25, MUC17, PRAP1, CGN, SI, ARL14, FABP2, EPS8L3, CDHR5 (Tabula Sapiens)
④ 종류 3. paneth cell of epithelium of large intestine
⑤ 종류 4. paneth cell of epithelium of small intestine
○ (+) GOLM1, CTSE, ANXA10, ONECUT2, CDHR5, TSPAN8, CDHR2, KRT20, MUC3A, SLC5A1 (Tabula Sapiens)
⑥ 종류 5. paneth cell of colon
○ (+) CA7, OTOP2, BEST4, GUCA2A, FRMD1, SPIB, CLDN3, HEPACAM2, KRT20, SDCBP2 (Tabula Sapiens)
⑦ 종류 6. serous cell of epithelium of bronchus
○ (+) C6orf58, CXCL17, CCDC129, LINC01482, PRR4, BPIFB1, DMBT1, ATP12A, TCN1, GLYATL2 (Tabula Sapiens)
⑧ 종류 7. serous cell of epithelium of trachea
○ (+) GLYATL2, BPIFB1, PROM1, MUC5B, BPIFA1, TMC5, SCGB3A1, AGR2, DMBT1, FCGBP (Tabula Sapiens)
⑨ 종류 8. mesothelial cell
○ (+) AP000705.7, HAS1, TNNT1, BNC1, DSC3, WT1, WNT10A, C21orf62, PTPRQ, CEMP1, C3, CRB2, KLK11, PHYHIP, TGM1 (sc-type)
⑿ kidney epithelial cell
① (+) NAT8, AC093326.1, SLC13A1, MIOX, TMEM27, GLYAT, PDZK1, TINAG, BBOX1, AC009014.3 (Tabula Sapiens)
② 종류 1. loop of Henle cell
○ (+) UMOD, AQP1, IRX1, IRX2, IRX3, MECOM, POU3F3, TBC1D4, SLC12A1, DEFB1, GEM, RGS5, CYP4B1, DRAM1, NEK6, CDKN1C, CALCRL, CLCNKA, CRYAB, SPP1, PPP1R1B, LRRC66, IGF1, CLDN1, CLDN10 (sc-type)
○ (+) CXCL1, GEM, THBS1, PTGS2 (PanglaoDB)
○ 1-1. loop of Henle ascending limb epithelial cell
○ (+) Slc12a1, Umod, Egf, Wfdc15b, Gpx6, Nccrp1, Clcnka, Ppp1r1a, Kng2, Cldn19 (Tabula Muris)
○ 1-1-1. loop of Henle thick ascending limb epithelial cell
○ (+) KNG1, FXYD2, UMOD, LOC109729779, ATP1B1, ATP1A1, LOC105865250, SLC12A1, DNASE1, LDHB (Tabula Microcebus)
○ 1-1-2. loop of Henle thin ascending limb epithelial cell
○ (+) SPP1, FXYD2, WFDC2, ZC3H10, KNG1, UMOD, CTSD, S100A6, RPS18, TMEM176B, (Tabula Microcebus)
○ 1-2. loop of Henle descending limb epithelial cell
○ 1-2-1. loop of Henle thick descending limb epithelial cell
○ 1-2-2. loop of Henle thin descending limb epithelial cell
○ (+) SPP1, CLU, ZC3H10, PTGDS, FXYD2, RPS18, AQP1, RPL26, CTSD, S100A6 (Tabula Microcebus)
③ 종류 2. collecting duct cell
○ (+) Slc12a3, Rhcg, Calb1, Spink8, Pgam2, Uroc1, D630042F21Rik, Hsd11b2, Slc26a4, Emx1 (Tabula Muris)
○ 2-1. α-intercalated cell
○ (+) ATP6V1G3, ATP6AP2, RHBG, ATP1B1, LOC109729779, RHCG, LOC105879013, FOXI1, AQP6, AU129_gr01 (Tabula Microcebus)
○ (+) FOXI1, OXGR1, ATP6V1G3, AQP6, CA2, NR1I4, SLC4A1, RHCG, ATP6V1B1, AVPR1A, P2RY14, FXYD2, TMEM213, CA2, DMRT2 (sc-type)
○ 2-2. β-intercalated cell
○ (+) FOXI1, OXGR1, ATP6V1G3, SLC26A4, CA2, NR1I4, RHCG, ATP6V1B1, AVPR1A, INSRR, FXYD2, TMEM213, CA2, AP1S3 (sc-type)
○ 2-3. principal cells
○ (+) KCNE1, APELA, AQP2, AQP3, GATA3, ELF5, STC1, TBX3, CLDN4, KCNJ1, AVPR2, FXYD4, HSD11B2, SCNN1G (sc-type)
○ 2-4. inner Medullary cell
○ (+) S100A4, PLEKHB1, ALDH1A3, TM6SF1, SLC14A2 (sc-type)
④ 종류 3. renal tubular cell
○ (+) Dach1, Calb1
○ 3-1. renal distal tubule cell
○ (+) KLK1, KCNJ1, KL, EGF, TMEM213, TMEM52B, SOSTDC1, SLC12A3, EMX1, CLDN3, CLDN8, UMOD, PCOLCE, CDC42EP3, CLCNKB, FXYD2, POU3F3 (sc-type)
○ 3-2. renal proximal tubular cell
○ (+) 0610005C13Rik
○ (+) FXYD2, ATP1B1, SLC3A1, CUBN, PDZK1, LRP2, POU3F3, AGXT2, GSTA2, CYP2E1, CRYL1, GLYAT, SORD, UPB1, SOD3, HNF4A, CDKN3, NAPSA, SLC7A13, SLC17A3, HGD (sc-type)
○ (+) DPP4, ENPEP, LRP2, PDZK1, SLC34A1, ASS1, PCK1, SLC4A4, GLYAT, FBP1, FOLR1, AK4, SLC5A8, FAH, CRYL1, SLC13A1, TMEM27, APOE, HGD, SERPINF2 (PanglaoDB)
○ 3-2-1. kidney proximal straight tubule epithelial cell
○ (+) Spink3, Slc34a1, Slc39a5, Miox, Slc13a1, Rdh16, Ugt2a3, Lrrc19, Pck1, Slc22a8 (Tabula Muris)
○ (+) ALDOB, FXYD2, GPX3, MIOX, SMIM24, APOC3, LOC105867418, SPP1, AQP1, AU129_gr01 (Tabula Microcebus)
○ 3-2-2. kidney proximal convoluted tubule epithelial cell
○ (+) GPX3, ALDOB, FXYD2, MIOX, APOC3, LOC105866477, SMIM24, AU129_gr01, SLC34A1, LOC105867418 (Tabula Microcebus)
○ 3-3. connecting tubule cell
○ (+) CALB1, TRPV5, FXYD2, ATP6V1B1, SLC8A1 (sc-type)
⑤ 종류 4. ureteric bud cell
○ (+) GFRA1, RET, WNT9B, CLDN6, LAMA1, NMU, Wnt11, Etv4, WNT7B (sc-type)
⑥ 종류 5. conjunctival epithelial cell
○ (+) AQP5, POLR2J3, FAM83A, PAX6, GJB4, SYT8, SOX15, FGFBP1, SERPINB2, FAM110C (Tabula Sapiens)
⒀ lung epithelium
① 종류 1. airway epithelial cell
○ (+) ADH7, AQP1, CDH1, SEC14L3 (sc-type)
② 종류 2. epithelial cell
○ (+) ANPEP, EPCAM, IL10, IL6R (sc-type)
③ 종류 3. alveolar epithelial cell
○ (+) T1a, AQP5
④ 종류 4. bronchial epithelial cell
○ (+) MUC5AC
⑤ 종류 5. type i pneumocyte (alveolar type i, AT1)
○ (+) GPRC5A, AGER, RTKN2
○ (+) AGER, AKAP5, AQP3, AQP5, CCN2, CLDN18, CLIC5, COL4A3, COL4A4, CRLF1, CYP4B1, EGFL6, EMP2, FSTL3, GPRC5A, HOPX, ICAM1, IGFBP6, KRT7, MEX3B, MMP11, P2RX7, PDPN, PXDC1, RTKN2, SCNN1A, SCNN1B, SCNN1G, SEC14L3, SEMA3B, SEMA3E, SMARCA1, VEGFA (sc-type)
○ (+) AGER, GGTLC1, MS4A15, CEACAM6, ANKRD29, AQP4, C4BPA, KAL1, ATP13A4, ARHGEF26 (Tabula Sapiens)
⑥ 종류 6. type ii pneumocyte (alveolar type ii, AT2)
○ (+) SFTPB, SFTPC, MUC1, SLC34A2, Foxp2, Nkx2-1, Tmem213, LYZ, ALPL
○ (+) GKN2, SFTPA1, SFTPA2, SLC22A31, SFTPC, SFTPD, ROS1, NAPSA, ABCA3, CACNA2D2 (Tabula Sapiens)
○ (+) SFTPC, LOC105870139, LOC105873688, LOC105883485, SFTPB, TMSB4X, LOC105879971, SFTPD, CTSH, CXCL17 (Tabula Microcebus)
○ (+) ABCA3, ADGRF5, AGER, CD36, CD3G, CEBPA, CLDN18, CRLF1, CTNND1, CXCL2, CXCR2, DDX3Y, EGFL6, ETV5, GRK2, IL1B, INMT, IRX1, LAMP3, LPCAT1, LRG1, MUC1, NAPSA, NKX2-1, NRN1, PGC, PIGR, PPBP, PPP1R14C, RUNX3, S100G, SDC1, SFTA2, SFTPA1, SFTPB, SFTPC, SFTPD, SLC34A2, SOAT1 (sc-type)
○ (+) NKX2-1, MUC1, CLDN18, LAMP3, lSFTA2, SFTPD, SLC34A2, SFTPB, SFTPA1, SFTPC, ADGRF5, LPCAT1, NAPSA, ABCA3, PGC, CXCL2, PIGR (PanglaoDB)
⑦ 종류 7. cycling epithelial cell
⑧ 종류 8. ECM-high epithelial cell
⑨ 종류 9. tuft-like
⑩ 종류 10. club cell
○ (+) Scgb3a2, S100a6, Aqp5
○ (+) CYP2B7P, FOLR1, NEDD4L, KIAA1244, SCGB3A1, AGR3, OCLN, SHROOM3, ERBB2, CXCL17 (Tabula Sapiens)
○ 10-1. airway club cell
⑪ 종류 11. trachea double-positive, alpha-beta thymocyte
⑫ 종류 12. mesothelial cell
○ (+) C2, CALB2, CD44, CDH1, DES, EFEMP1, EPCAM, GSTA3, KRT5, KRT7, KRT72, LGALS7, LRRN4, ME1, ME2, MSLN, MUC16, OSR1, RSPO1, THBD, UPK3B, WT1 (sc-type)
⑬ 종류 13. tracheal goblet cell
○ (+) MUC5AC, RP11-412H8.2, BPIFA1, BPIFB1, MUC5B, ATP12A, CXCL17, AGR2, VMO1, LCN2 (Tabula Sapiens)
⒁ myoepithelial cell
① (+) KRT1
② (+) FBXO2, MYLK, ACTG2, SYNM, TFAP2C, KCNMB1, FAT1, SAA1, MIR143HG, KRT17 (Tabula Sapiens)
③ 종류 1. breast myoepithelial cell
○ (+) ACTG2, C6orf132, DSP, DST, GLIPR1, KARS, KLF5, KRT5, KRT6B, MYLK, NARS, OXTR, PTN, TRAF4, TUBB2B
⒂ neuroepithelial cell
① (+) NES, SOX2, NOTCH1, HES1, HES3, CDH1, OCLN, SOX10 (sc-type)
⒃ pancreatic epithelium
① 종류 1. cancer stem cell
○ (+) CD24, CD44, FLOT2
② 종류 2. pancreatic ductal cell
○ (+) CFTR, HNF1B, KRT20, MUC1, ONECUT1, AMBP, HHEX, ANXA4, SPP1, PDX1, CFB, GDF15, AKR1C3, MMP7, DEFB1, SERPING1, TSPAN8, CLDN10, SLPI, SERPINA5, PIGR, CLDN1, LGALS4, PERP, PDLIM3, WFDC2, AQP1, ALDH1A3, KRT19, TFF1, TFF2 (sc-type)
○ (+) SLC4A4, CFTR, CLDN10, RP11-528G1.2, SCTR, PKHD1, SFRP5, DCDC2, ANXA4, RP11-680F8.1 (Tabula Sapiens)
○ (+) GDF15, MMP7, SLPI, PERP, WFDC2, KRT19, KRT7, CLDN4, TACSTD2, CTSH, S100A10 (PanglaoDB)
⒄ prostate epithelium
① 종류 1. basal cell of prostate epithelium
○ (+) HCAR2, HCAR3, CYP4F8, RMST, HOXB8, SLC16A12, SPINK2, TNS4, GATA3-AS1, PIK3C2G (Tabula Sapiens)
② 종류 2. club cell of prostate epithelium
③ 종류 3. glandular cell
④ 종류 4. hillock cell of prostate epithelium
⑤ 종류 5. hillock-club cell of prostate epithelium
⑥ 종류 6. luminal cell of prostate epithelium
○ (+) KLK3, KLK2, ACPP, LINC01297, KLK4, NEFH, RP11-356O9.1, RPL7P16, RP11-388N2.1, NKX3-1 (Tabula Sapiens)
⒅ squamous epithelial cell
⒆ stomach epithelial cell
① 종류 1. ciliated epithelial cell
○ (+) CCDC37, C11orf88, FAM216B, LDLRAD1, TUBA4B, KIF19, DYDC2, ANKRD66, C9orf117, C10orf67, AC013264.2, LRRC71, CAPSL, TSPAN19, STOML3 (sc-type)
② 종류 2. squamous epithelial cell
○ (+) KRT6B, CAPNS2, KRT6C, FGFBP1, KRT6A, KRT17, ADH7, SERPINB10, KRT16, S100A3, CLCA2, LY6D, KRT4, AC019349.5, GPR87 (sc-type)
③ 종류 3. mesothelial cell
○ (+) RP11-74M11.2, AP000705.7, BNC1, SPHKAP, PTPRQ, NPHS1, TNNT1, TFPI2, BDNF, PDZRN4, LRP2, GFPT2, HAS1, WT1, COL8A1 (sc-type)
⒇ surface ectodermal cell
① (+) CCL21, RELN, MMRN1, PKHD1L1, ANGPT2, WFS1, SCN3B, SEMA3A, PIEZO2, PROX1 (Tabula Sapiens)
⒇ thymic epithelial cell
① (+) Tcrg-C1, Tbata
② (+) RP11-81F13.2, KCNJ5, RP11-153K16.1, RP11-81F13.1, LL22NC03-75H12.2, RP11-112J1.2, RP11-114G22.1, RP6-24A23.6, C11orf16, SLC46A2, CACNA1I, PTPRT, NPFFR2, RP1-223B1.1, C12orf56 (sc-type)
③ 종류 1. DN3 thymocyte
○ (+) TRBV25-1, TRAC, BCL11B, AP3M2, CD48, RPL22, TRBC2, RRN3P1, CD3D, TCF7 (Tabula Sapiens)
④ 종류 2. DN4 thymocyte
○ (+) CENPF, TOP2A, KIFC1, KIF14, CEP55, FAM72B, NUSAP1, UBE2C, KIF15, TPX2 (Tabula Sapiens)
⑤ 종류 3. double-positive, alpha-beta thymocyte
⑥ 종류 4. medullary thymic epithelial cell
○ (+) ITLN1, GALNT9, ITLN2, HP, UPK3B, MSLN, CFB, CALB2, PRG4, C1QL1
⒇ bladder epithelium
① 종류 1. bladder cell
○ (+) Asz1, Tgm5, Car3, Cck, Pitx1, Cntn4, Krtdap, Prss35, Hoxa11, Cpz (Tabula Muris)
② 종류 2. bladder urothelial cell
○ (+) DHRS2, BTBD16, UPK1A, TRIM31, PADI3, ATP1A4, PSCA, APOL1, VSIG2, UPK3A (Tabula Sapiens)
○ (+) Krt39, Muc15, Sprr2b, Ugt2b35, Gpa33, Upk1a, Sprr1a, Ivl, Gjb6, 1110032A04Rik (Tabula Muris)
○ (+) ZC3H10, RPS27, RPS18, RPLP1, RPS28, S100A6, RPL37, LOC105857397, RPL36, RPL37A (Tabula Miceocebus)
⒇ uterus epithelium
① 종류 1. epithelial cell of uterus
○ (+) LINC01541, ASRGL1, UCA1, SCGB2A1, PAEP, STX18, SEMA3B, DLX5, PAPSS1, ITGB8 (Tabula Sapiens)
⒇ mesothelial cell
① (+) SERTM1, SYT4, ITLN1, GALNT9, MGAT4C, UPK3B, PTPRQ", RP11-826N14.4, TMTC2 (Tabula Sapiens)
② (+) INS, REG3G, RPS18, S100A6, ZC3H10, TMSB4X, LOC105875474, RPS27, PRSS2, S100A4 (Tabula Microcebus)
③ (+) CALB2, MUC16, KRT5, KRT7, MSLN, WT1, PKHD1L1, SULF1, MIR22HG, COBLL1, GBP2, MEDAG, CRLS1, EFEMP1, RSPO1, RARRES2 (PanglaoDB)
④ 종류 1. lung mesothelial cell
○ (+) C2, CALB2, CD44, CDH1, DES, EFEMP1, EPCAM, GSTA3, KRT5, KRT7, KRT72, LGALS7, LRRN4, ME1, ME2, MSLN, MUC16, OSR1, RSPO1, THBD, UPK3B, WT1 (sc-type)
⑤ 종류 2. intestine mesothelial cell
○ (+) AP000705.7, HAS1, TNNT1, BNC1, DSC3, WT1, WNT10A, C21orf62, PTPRQ, CEMP1, C3, CRB2, KLK11, PHYHIP, TGM1 (sc-type)
⑥ 종류 3. spleen mesothelial cell
○ (+) QRFPR, SLPI, LHX9, PLA2G2A, CGN, NPHS1, KRT5, LRRN4, KLK11, OLR1, PTPRQ, COL8A1, PDZK1IP1, HAS1, SFRP2 (sc-type)
⑦ 종류 4. stomach mesothelial cell
○ (+) RP11-74M11.2, AP000705.7, BNC1, SPHKAP,P TPRQ, NPHS1, TNNT1, TFPI2, BDNF, PDZRN4, LRP2, GFPT2, HAS1, WT1, COL8A1 (sc-type)
⒇ tongue epithelium
① 종류 1. taste receptor cell
② 종류 2. salivary mucuous cell
○ (+) KRT14, THBS1, KRT17 (PanglaoDB)
③ 종류 3. acinar cell of salivary gland
○ (+) BPIFA2, LPO, PRB2, CA6, PRB1, MUCL1, PRH1, PRB4, PRH2, HTN1 (Tabula Sapiens)
⒇ olfactory epithelial cell
⒇ skin epithelium
① 종류 1. keratinocyte
○ (+) KRT4, IGFL1, LGALS7, SPINK5, RHCG, GBP6, IVL, CYSRT1, THEM5, SULT2B1 (Tabula Sapiens)
○ (+) CALML5, CD24, KRT5, KRT14, KRT17, AQP3, KRT15, S100A14, SFN, KRT10 (PanglaoDB)
② 종류 2. melanocyte
③ 종류 3. merkel cell
④ 종류 4. sebocyte(피지세포)
⑤ 종류 5. trichocyte
3. 유형 2. endothelial cell (내피세포) [목차]
⑴ 개요 : pan-endothelial cell (모든 내피세포)
① (+) CD31(PECAM1), CD34, VWF, PLVAP, CDH5, TIE-2, Axin2, WARS, AQP1, TIFA
② (+) PECAM1, CD34, KDR, CDH5, PROM1, PDPN, TEK, FLT1, VCAM1, PTPRC, VWF, ENG, MCAM, ICAM1, FLT4, SELE (sc-type)
③ (+) TM4SF18, PLVAP, WWTR1, MKL2, SOX18, CD320, S1PR1, NOTCH4, RAPGEF5, LIMS2 (Tabula Sapiens)
④ (+) Tlx1, Gm694, C1qtnf9, Kcna5, Rbp7, Fabp4, Aqp7, Glycam1, Apold1, Sele (Tabula Muris)
⑤ (+) PECAM1, VWF, CLEC14A, EMP1, RNASE1, CTGF, HYAL2, CALCRL, EMCN, ADGRL4, CLDN5, ECSCR, CDH5, TGFBR2, ENG, EGFL7, FLT1, EPAS1, CD34, SRGN, S100A10, IGFBP7, SPARC, SLC9A3R2, MGP, SPARCL1, TM4SF1, ID1, CD9, ID3, CAV1, GNG11, S100A13,IFI27, PCAT19, TIMP3 (PanglaoDB)
⑥ (+) CLDN5, TIE1, VWF, KDR, ROBO4, EMCN, MYCT1, HYAL2, TEK, ACVRL1, FLT4, MMRN2, ANGPT2, ARHGEF15, CD93 (SCEVAN)
⑵ adrenal vascular endothelial cell
① (+) CCL23, FGF23, SMIM9, RP13-1016M1.2, RP11-100L22.1, RP11-327L3.3, RP1-149A16.12, GPR182, DLL4, GALNT15, CALCRL, CD300LG, FLT4, FCN3, GPIHBP1 (sc-type)
⑶ angiogenic endothelial cells
① (+) CD105, VEGFR2, KIT, NRP2, COL15A1, PCDH17, ITGA6
⑷ pericyte : endothelial cell을 감싸는 fibroblast-like cell
① (+) NG2
② (+) GUCY1A2, COX4I2, NDUFA4L2, RGS5, NOTCH3, GJA4, GUCY1B3, FHL5, STEAP4, C2orf40 (Tabula Sapiens)
③ (+) PDGFRB, NOTCH3, COX4I2, HIGD1B, MCAM, NDUFA4L2, VIM, MFGE8 (PanglaoDB)
⑸ 조직 1. cardiovascular system
① 종류 1. artery endothelial cell
② 종류 2. capillary aerocyte(기체세포)
③ 종류 3. capillary endothelial cell
○ (+) FCN3, CA4, GPIHBP1, CD300LG, CDH5, PODXL, ROBO4, EMCN, BTNL9, HYAL2 (Tabula Sapiens)
○ (+) LOC105857591, B2M, LOC105855951, RAMP2, CD74, LOC105867540, MFGE8, CALCRL, RAMP1, LOC105856764 (Tabula Microcebus)
④ 종류 4. cardiac endothelial cell
○ (+) H19, CLIC5, F8, SLC14A1, TNNT3, MCF2L, KANK3, TMEM88, TCF15, TSPAN18 (Tabula Sapiens)
⑤ 종류 5. endothelial cell of artery
○ (+) IGFBP3, SEMA3G, MECOM, HEY1, CLEC14A, KIAA1462, JAM2, EFNB2, PIK3R3, SHE (Tabula Sapiens)
⑥ 종류 6. endothelial cell of vascular tree
○ (+) SELE, IL6, RND1, CNKSR3, STC1, SELP, ACKR1, SOX7, ADAMTS9, OLFM1 (Tabula Sapiens)
⑦ 종류 7. vein endothelial cell
○ (+) CCL14, OLFM1, ACKR1, DOC2B, PLVAP, FAM110D, RAMP3, SELP, LPCAT4, SLCO2A1 (Tabula Sapiens)
○ (+) TMSB4X, ZC3H10, ACKR1, RPS18, LOC105857591, ADIRF, SELE, B2M, RPS12, RPL37A (Tabula Microcebus)
⑧ 종류 8. endothelial cell of lymphatic vessel
○ (+) LYVE1
○ (+) MMRN1, CCL21, PKHD1L1, PROX1, FLT4, SMAD1, TFF3, NR2F1, RHOJ, LAYN (Tabula Sapiens)
○ (+) CCL21, B2M, ADIRF, VIM, RAMP2, TMEM176B, PLAC9, MMRN1, TIMP3, LOC105855951 (Tabula Microcebus)
⑨ 종류 9. lymphatic endothelial cell of heart
○ (+) GPR182, GPR97, STAB2, HOXD9, TBX1, CCL21, HOXD10, TSPEAR, ABCA4, PGM5-AS1, TFF3, LINC00636, RP11-341G23.4, HOXD4, RP11-451M19.3 (sc-type)
⑩ 종류 10. vascular endothelial cell of heart
○ (+) ESM1, SLC9C1, OPN5, QRFPR, MIR4454, AC007743.1, PKD1L1, TM4SF18, APLNR, CLRN1-AS1, CD300LG, C1QTNF9, AC019100.3, MADCAM1, RP11-298O21.5 (sc-type)
⑪ 종류 11. blood vessel endothelial cell
○ (+) EPHX4, POSTN, CCL14, TMEM255B, LCN6, CYTL1, NOS3, ACKR1, RILPL1, HSPA12B (Tabula Sapiens)
⑫ 종류 12. vasa recta ascending limb cell
○ (+) LOC105855951, B2M, HYAL4, LOC105869179, LOC105871594, LOC105870764, LOC105870765, S100A6, RAMP2, CD74 (Tabula Microcebus)
⑬ 종류 13. vasa recta descending limb cell
○ (+) S100A6, AQP1, TIMP3, S100A4, TMSB4X, LOC105855951, HSPB1, MGP, B2M, JUN (Tabula Microcebus)
⑹ 조직 2. digestive system
① 종류 1. endothelial cell of hepatic sinusoid
○ (+) OIT3, CRHBP, CLEC4G, IL33, INSR, DNASE1L3, HECW2, BMPER, FAM167B, NTN4 (Tabula Sapiens)
② 종류 2. gut endothelial cell
○ (+) PCAT19, GPR126, FOXC1, JAM2, NRN1, CLDN5, SLCO2A1, THBD, PTPRB, ICAM1 (Tabula Sapiens)
③ 종류 3. liver endothelial cell
○ (+) FLT1, APPBP2, ARGLU1, ATP10D, BNIP1, BST2, BTNL9, C11orf96, CCDC85B, CCL14, CD4, CDC73, CDKL1, CHD4, CLEC1B, CLEC2B, CLEC4G, CLEC4M, CRBN, CRHBP, CTSL, DCLRE1C, DIPK2A, DLC1, DLG1, DLK1, DNASE1L3, DOCK1, DUSP5, EFNB2, ENG, F8, FCN2, FCN3, FILIP1, FOSB, FXYD6, GBP4, GGA2, GNG11, HES1, HYI, IL1R1, IL33, KDR, KIF1B, KLHL28, LDB2, MCAM, MCM3AP, MEF2C, MFN1, MGAT5, MPZL3, MRC1, OIT3, PIK3C2A, PPWD1, PTPRC, RASGEF1B, RASGRP3, RELN, RIN2, SECISBP2L, STAB1, STRN3, TCF12, TEX264, TFRC, TRAPPC11, TSPAN7, USP48, VWF, ZNF286B, STAB2, CD34, PECAM1 (sc-type)
④ 종류 4. vascular endothelial cell of intestine
○ (+) SOX17, GPIHBP1, PRND, CLEC3B, FLT1, MMRN2, BTNL9, APLNR, LHX6, NOTCH4, RP11-3K16.2, ESAM, RP11-328D5.1, ESM1, GJA5 (sc-type)
⑤ 종류 5. lymphatic endothelial cell of intestine
○ (+) RP11-474N8.5, TBX1, STAB2, CCL21, LINC00636, TSPEAR, ART5, CTC-236F12.4, GPR1, RP11-322E11.5, MPP7, Y_RNA, ABCA4, PLIN5, TP63 (sc-type)
⑥ 종류 6. vascular endothelial cell of stomach
○ (+) SELE, PRND, APLNR, ARHGEF15, PLVAP, FLT1, PCDH12, MADCAM1, GPIHBP1, GALNT15, RP4-601K24.1, MEOX1, A2M, CCM2L, CLEC14A (sc-type)
⑦ 종류 7. lymphatic endothelial cell of stomach
○ (+) NTS, STAB2, CCL21, RADIL, RP11-444A22.1, TFPI, RP11-142C4.6, TNFAIP8L3, LY86-AS1, PTGS2, RP11-554D15.1, EFCC1, MMRN1, Y_RNA, NFATC1 (sc-type)
⑧ 종류 8. portal vein
○ (+) Adgrg6, Gja5
⑺ 조직 3. excretory system
① 종류 1. kidney endothelial cell
○ (+) F8, AU021092, Emcn, Fam167b, Rsad2, Plvap, Esm1, Cldn15, Bhlhe22, Ppap2a (Tabula Muris)
○ (+) TGFBR2, NOTCH4, ADGRL4, EMCN, ENG, PECAM1, PLAC8, PLVAP, TEK, KDR, VWF, MMRN1, CD93 (sc-type)
○ 1-1. renal vesicle cell
○ (+) NCAM1, EMX2, LHX1, BMP2, DKK1, DLL1, GREB1, PAPSS2, PCSK9, POU3F3, TMEM100, WT1 (sc-type)
② 종류 2. bladder endothelial cell
○ capillary endothelial cell
○ endothelial cell of lymphatic vessel
○ vein endothelial cell
⑻ 조직 4. muscle endothelial cell
① 종류 1. lymphatic endothelial cell
○ (+) NTS, TFF3, CCL21, STAB2, PTX3, PCLO, IL7, P4HA3,C 6orf141, PIK3C2G, ASGR2, ANKRD36BP2, NALCN, FAM26F, NHLRC1 (sc-type)
② 종류 2. vascular endothelial cell
○ (+) MIR4454, SLC5A4, AL118508.1, CA4, RP11-206M11.7, PRSS51, NOS3, GRIN2A, GFRAL, CD300LG, MADCAM1, RP11-327L3.3, C1QTNF9, ANO2, AP001597.1 (sc-type)
⑼ 조직 5. nerve system
① 종류 1. retinal blood vessel endothelial cell
○ (+) LCN1, LACRT, SELP, ELOVL7, SELE, SYT15, MYRIP, CXorf36, THSD7A, CD200 (Tabula Sapiens)
② 종류 2. eye endothelial cell
○ (+) PECAM1, VWF, CDH5, BMP2, BMP4, CD34, CD55, FLT1, MED1, TGFBR1, TMEM98, TNFSF12, CD93, SLCO1A4, CLDN5, ICAM1, GNG11 (sc-type)
③ 종류 3. brain endothelial cell
○ (+) PECAM1, VWF, A2M, APOLD1, FLT1, TM4SF1, CD34, MCAM, ENG, PTPRC, VCAM1, CDH5 (sc-type)
⑽ 조직 6. prostate endothelial cell
① (+) PECAM1, CD34, MCAM, CDH5, VWF, ENG, KDR, PDPN, SELE, A2M (sc-type)
⑾ 조직 7. respiratory system
① 종류 1. lung endothelial cell
○ (+) Cldn5, Hpgd, Rasgef1a, Tmem100, Lyve1, Adrb1, Clec14a, Prx, Ripply3, Sox11 (Tabula Muris)
○ (+) CD34, EGFL7, EMCN, ESAM, FLT1, KDR, MCAM, PECAM1, RAMP2, TEK, VWF (sc-type)
② 종류 2. bronchial vessel endothelial cell
③ 종류 3. arterial endothelial cell
④ 종류 4. capillary endothelial cell
⑤ 종류 5. inflamed endothelial cell
⑥ 종류 6. pulmonary venous endothelial cell
⑦ 종류 7. systemic venous endothelial cell
⑧ 종류 8. lung microvascular endothelial cell
○ (+) ACKR1, CPLX1, NRN1, CCL23, CCL14, OLFM1, HERC2P2, FAM110D, RAMP3, CLDN5
⑿ 조직 8. vascular endothelial cell of placenta
① (+) RP11-1028N23.4, RP11-297H3.3, AC007743.1, RP11-327L3.3, CD34, ARHGEF15, CXorf36, LRRC36, SOX7, RP11-328D5.1, NTS, CDRT1, LINC01049, ROBO4, HS3ST3A1 (sc-type)
⒀ 조직 9. vascular endothelial cell of spleen
① (+) RP11-189E14.5, ODF3L2, RP4-765C7.2, AC019100.3, RP11-172F10.1, CTD-2207L17.2, RP1-154K9.2, AC010084.1, SLC5A4, OR5G5P, HOXD3, SNTG1, EEF1A1P31, ADAMTSL1, MYRIP (sc-type)
⒁ 조직 10. vascular endothelial cell of thymus
① (+) ADAMTS9, PROX1, MET, AC011526.1, MEOX2, ANO2, CTD-3179P9.1, NOVA2, AOC3, CXorf36, GPR116, PODXL, NRN1, PTPRB, LINC00472 (sc-type)
⒂ 조직 11. tumor-associated endothelial cell (TEC)
① (+) CD144
4. 유형 3. immune cell (면역세포) [목차]
⑴ 면역세포
① (+) LCP2, LSP1, FYB, PLEK, HCK, IL10RA, LILRB1, NCKAP1L, LAIR1, NCF2, CYBB, PTPRC, IL7R, LAPTM5, CD53 (SCEVAN)
⑵ 대분류 I. leucocyte(백혈구)
① (+) CD45
② (+) SPRR2D, S100A7, SPRR2E, TIPARP, RUNX3, CD3G, GLIPR1, GPR183, RGS1, SPRR2A (Tabula Sapiens)
③ 소분류 A. lymphoid cell
○ (+) NK1.1, B220, CD4, CD8
○ (+) CCL5, TMSB10, RPS27, LOC105874071, RPL13A, RPLP1, IL32, RPS11, GZMA, RPS15A (Tabula Microcebus)
○ 상태 1. innate lymphoid cell
○ (+) TCF7, CD69, TAGAP, AREG, TRAC, PIK3IP1, IL7R, CXCR4 (Tabula Sapiens)
④ 소분류 B. myeloid cell (골수세포)
○ (+) CD68, CD14, CD11b, ITGAX (CD11c), ADGRE1, MHC-II, Ly6G, Ly6C, CD86, HLA-DRA, F4/80, CST3, LYZ
○ (+) GPR34, CCR1, HLA-DRB5, C3AR1, CD68, CSF1R, SLC1A3, CLEC7A, MAFB, SIGLEC10 (Tabula Sapiens)
⑤ 상태 1. ISG (interferon-stimulated gene) expressing immune cell
○ (+) IFIT1, IFIT2, IFIT3, IFIT5, ISG15, CCL3, CCL4, CCL3L3, RSAD2, OASL, CXCL10, IFI15, ISG20 (sc-type)
⑶ A-1. B cell (B lymphocyte)
① pan-B cell
○ (+) CD19 (거의 B 셀에서만 발현), CD20 (MS4A1), CD79A, CD79B, BLK, PTPRC, CD24, CD40, CD72, CD220, APOBEC3A, PELI1, ANKRD28, C2orf42, CCPG1, CLECL1, DNAAF1, DUSP5, ERN1, FAM107B, ITM2C, LGALSL, RAB30, SLAMF1, TRIB1, VOPP1
○ (+) TNFRSF5, CLEC2C, FCRL4, HAVCR1, CR2, IL35, LILRB1, SPN, TLR9, TNFRSF13C, TNFRSF17, XBP1, MME
○ (+) LINC01781, BLK, TNFRSF13B, CD19, VPREB3, LY9, GNG7, BANK1, MS4A1, LINC02397 (Tabula Sapiens)
○ (+) Ms4a1, Cd79a, Crisp3, Faim3, Cd79b, Fcer2a, Tnfrsf13c, Cr2, Bank1, Cd19 (Tabula Muris)
○ (+) CD74, RPS27, RPL12, RPS15A, RPS28, RPL37, LOC105855163, RPL23A, RPL27A, RPS11 (Tabula Microcebus)
○ (+) CD69, CD79A, CD79B, IGHM, HLA-DRA, LTB, MZB1, VPREB3, CXCR4, IGLC2, IGKC, BCL11A, CD74, CD52 (PanglaoDB)
○ (+) HLA-DOB, HLA-DQA1, MS4A1, CD79B, BLK, GNG7, SPIB, TCL1A, FCRLA, HVCN1, NCF1, BANK1, CD79A, CD19, VPREB3 (SCEVAN)
② 종류 1. pre-pro-B cell
○ (+) Cd19, Cd43, Cd45r, Cd127, BP-1, cµ, λ5
○ (-) Cd19, Cd2
③ 종류 2. pro-B cell
○ (+) CD19, CD20, CD34, CD38, CD45R, CD22
○ (+) CD27, IgD, CD24, PTPRC, PAX5, CD24, CD38, CD79A, DNTT, C10orf10, VPREB1, ARPP21, CD99, IGLL1, CD9, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, VPREB3, IGLL5 (sc-type)
○ 2-1. large-pro-B cell (mouse)
○ (+) Cd19, Cd43, Cd45r, Cd127, BP-1, HSA, λ5
○ (-) Cd2, Cd22, Cd117, cµ
④ 종류 3. pre-B cell
○ (+) CD19, CD20, CD38, CD40, CD45R, CD34
○ (+) CD19, CD27, IgD, CD24, PTPRC, PAX5, CD24, CD38, CD79A, NSMCE1, PCDH9, ACSM3, CCDC191, TCL1A, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, VPREB3, IGLL5 (sc-type)
○ 3-1. large-pre-B cell (mouse)
○ (+) Cd19, Cd45r, Cd127, BP-1, cµ
○ (-) Cd2
○ 3-2. small-pre-B cell (mouse)
○ (+) Cd2, Cd19, Cd127, B220, cµ
○ (-) Cd43, sµ
⑤ 종류 4. immature B cell
○ (+) CD19, CD20, CD40, CD45R, IgM, CD38, CD5, CD53
⑥ 종류 5. transitional B cell
○ (+) CD10, CD19, CD20, CD25, CD30
○ (-) CD27
○ 5-1. transitional 1 (T1) B cell
○ (+) B220, Cd19
○ (-) Cd23
○ 5-2. transitional 2 (T2) B cell
○ (+) Cd23, Cd93, B220, IgD
⑦ 종류 6. marginal zone B cell
○ (+) CD1, CD19, CD20, CD21, CD27, Notch2, Cd1d, Cd21, Cd93, HSA, CD1D
○ (-) Cd35
⑧ 종류 7. follicular B cell / B2 cell
○ (+) IgD, CD21, CD22, CD23, Cd19, Cd21, Cd35, Cd93
⑨ 종류 8. B1 cell
○ (+) Cd11b, CD19, CD20, CD27, CD43, CD70, IgM, CD5
○ (-) Cd23, CD38
○ 8-1. B1 precursor
○ (+) Cd19, Cd45ra
○ (-) B220
⑩ 종류 9. plasma B cell (형질세포)
○ (+) CD27, CD38, CD40 CD78, CD95, CD138, CD319, IL-6, CXCR4, IGHG3, IGKC, IGHM, IGHG2, IGKV4-1, IGLV3-1, IGHA1, IGHG1, JCHAIN, Cd19, Cd138, IGKC, BCMA, BCL2, BCL6, XBP1
○ (+) CD27, IgD, CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, VPREB3, IGLL5 (sc-type)
○ (+) IGHG1, IGJ (JCHAIN), IGHG3, MZB1, TXNDC5, IGHG2, DERL3, IGLC2, IGHG4, IGLC3 (Tabula Sapiens)
○ (+) LOC109729893, LOC105882024, JCHAIN, LOC105877808, LOC105862709, MZB1, HERPUD1, B2M, RPLP1, RPS18 (Tabula Microcebus)
○ (+) SDC1, CD38, CD27, CYCS, CD74, TNFRSF17, CD79A, EAF2, GNG7, IGKC, MZB1, IGLC2, IGHG1, IGHG2, IGHG3, IGHGP, IGLC3, JCHAIN, IGHA1, IGHG4, IGHA2, SSR4 (PanglaoDB)
○ (-) CD20, CD79A, CD79B, BLNK, MS4A1, IgM, Cd21, Cd22, Cd23, IgD, IgM
○ (-) CD20, MS4A1 (sc-type)
⑪ 종류 10. memory B cell (기억세포)
○ (+) CD19, CD20, CD27, CD40, CD80, PDL-2, CXCR3, CXCR4, CXCR5, CXCR6, IgA, IgG, IgE, B220, MHC class II, BCL2, CD53, CD21, FAS
○ (+) CD19, CD27, IgD, CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, CD27, VPREB3, IGLL5 (sc-type)
○ (+) AIM2, ADAM28, TLR10, CD19, TNFRSF13B, CD22, P2RX5, RP5-887A10.1, SCIMP, MS4A1 (Tabula Sapiens)
○ (-) CD38, CD150
⑫ 종류 11. regulatory B cell (조절 B 세포)
○ (+) IgD, CD1, CD5, CD21, CD24, TLR4, IL-10, TGFβ
⑬ 종류 12. NF B cell
○ (+) B220, Cd2, Cd19, HSA, IgM
○ (-) Cd21, Cd23, Cd35
⑭ 종류 13. activated germinal B cell
○ (+) B220, MHC class II
⑮ 종류 14. Breg
○ (+) CD1D, CD27, CD5
⑯ 종류 15. mature B cell
○ (+) CD22, CD21
⑰ 상태 1. naïve B cell
○ (+) CD19, CD20, CD23, CD40, CD150, IgD, IgM, CD22, CD53, CD21
○ (+) CD19, IgD, CD38, CD24, CD20, MS4A1, PTPRC, PAX5, CD24, CD79A, JCHAIN, SSR4, FKBP11, SEC11C, DERL3, PRDX4, IGLL5, CD79B, TCL1A, IGLL5, HLA-DQA1, HLA-DQB1, CD138, VPREB3, IGLL5 (sc-type)
○ (+) TCL1A, IGHD, LINC00926, FCRL1, STAG3, RP11-693J15.5, FCER2, PAX5, FAM129C, CD22 (tabual sapiens)
○ (+) BANK1, CD37, CD69, CD79A, CD79B, IGHD, IGHM, IGKC, LTB, MS4A1, SELL, TCL1A, VPREB3, FOXP1, CD52, HLA-DQB1, TNFRSF13C, LINC00926, BIRC3, CD74 (PanglaoDB)
○ (-) CD27
⑱ 상태 2. switched B cell
○ (+) CD27
○ (-) IgD
⑲ 상태 3. unswitched B cell
○ (+) CD27, IgD
⑳ 상태 4. activated B cell
○ (+) CD80, CD86, FAS
⑳ 상태 5. functional B cell
○ (+) CD27, CCR7, CD197
⑷ A-2. T cell (T lymphocyte)
① pan-T cell (모든 T 세포)
○ (+) CD2, CD3 (CD3D, CD3E, CD3G), KLRC1, TUBA4A, TENT5C, CD274, CYTIP, GPR183, RHOH, SMAP2
○ (+) ICOS, LAG3, CD47, CCR10, CD58, ITGAE, ITGAL (LFA-1), PTGDR2, IL10, IL13, IL17A, IL2, IL21, IL22, IL25, IL26, IL5, IL9, IGFB1, FOXO4, FOXP1, TBX21
○ (+) CD96, SYTL3, RORA, IL7R, CD7, CD2, LEPROTL1, CNOT6L, TRACRUNX3 (Tabula Sapiens)
○ (+) Lcn4, Il7r, Folr4, Cd3d, Tnfsf8, Ms4a4b, Cd3g, Cd40lg, Vipr1, Cxcr6 (Tabula Muris)
○ (+) CCL5, TMSB10, IL32, LOC105874071, GZMA, LOC105858493, LOC105881712, S100A4, NKG7, CRIP1 (Tabula Microcebus)
○ (+) CD3D, CD3G, CD3E, LTB, IL7R, TRBC1, TRBC2, CD7, TRAC, IL32, CXCR4, CD2, CLEC2D, S100A4, LCK, JUNB, CD52 (PanglaoDB)
○ (+) HLA-B, PTPRC, SH2D1A, CD3E, LCK, CD48, ACAP1, GIMAP7, SEPTIN1, CD69, LINC00861, CDC42SE2, CD96, TSTD1, GIMAP4 (SCEVAN)
② 종류 1. helper T cell (Th)
○ (+) CD4
○ (+) LEF1, TCF7, BCL11B, CAMK4, ITK, IPCEF1, INPP4B, CD6, SCML4, PRKCQ-AS1 (Tabula Sapiens)
○ (+) AC092580.4, OXNAD1, KLRB1, STAT4, CRIP1, SYTL3, PDE4D, RCAN3, CD3G, RORA (Tabula Sapiens)
○ (+) LOC105855976, IL32, RPS27, LOC105874071, IL21, CGA, LRRC31, FOXP3, LOC105873674, GABBR2 (Tabula Microcebus)
○ 1-1. Th1 (helper T cell 1, 세포 도움 T세포 1)
○ (+) CD4, CXCR3, IFNγ, IL-2, IL-12, IL-18, STAT4, STAT, TNF, T-Bet, IFNG, GZMB, Tbx21
○ (-) CD8A, CD8B, FOXP3, IL2RA
○ 1-2. Th2 (helper T cell 2, 세포 도움 T세포 2)
○ (+) CD4, CCR4, IL-2, IL-4, GATA-3, Gata3
○ (-) CD8A, CD8B, FOXP3, IL2RA
○ 1-3. Th9
○ (+) PU.1, IL-9
○ 1-4. Th17
○ (+) RORγt, IL-17, RORA, RORC, RBPJ, BHLHE40, CCR6, IL23R, Rorc
○ Th17 chemoattraction
○ (+) CXCL16, CCL20
○ 1-5. Th22
○ (+) AHR, IL-22
○ 1-6. Tfh (T follicular helper cell)
○ (+) BCL6, CXCR5, IL-21
○ (+) AL135905.2, CD28, CD5, PBX4, KCNA3, CD7, CCR7, CD6, LSR, RP4-765C7.2 (Tabula Sapiens)
○ 1-7. effector CD4+ T cell
○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)
○ (+) TCF7, LEF1, ITK, BCL11B, CITED2, CD3E, CAMK4, IL7R, CD69, SPOCK2 (Tabula Sapiens)
○ (-) SELL, CCR7 (sc-type)
○ 1-8. memory CD4+ T cell
○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD45RO, CD6, CTLA4, IL2RA, GZMB, SELL, CCR7, S100A4, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)
○ (+) TRAT1, TRAC, LCK, BCL11B, TCF7, ITK, PIK3IP1, SPOCK2, IL7R, CD3G (Tabula Sapiens)
○ 1-9. metallothionein-expressing T cell : metallothionein은 세포를 산화적 스트레스와 세포 독성으로부터 보호함
○ (+) MT1, MT2
○ 1-10. SRRM2-T cell
○ (+) PNISR, SRRM2
○ 1-11. naïve CD4+ T cell
○ (+) CCR7, LEF1
○ (+) CD4, CD2, CD3D, CD3E, CD3G, CD3Z, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, SELL, CCR7, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)
○ (+) PRKCQ-AS1, CCR7, TXK, TRAC, NOSIP, LCK, TCF7, CCDC109B, BCL11B, PIK3IP1 (Tabula Sapiens)
○ (-) CD25, CD44, CD69, HLA-DRA, CD95 (sc-type)
③ 종류 2. cytotoxic T cell (Tc)
○ (+) CD8
○ (+) AC092580.4, CD8A, CD8B, CCL5, GZMA, KLRD1, SYTL3, CD2, CD3G, CD96 (Tabula Sapiens)
○ (+) CCL5, IL32, LOC105881712, LOC105874071, TMSB10, LOC105881288, GZMA, LOC105866296, NKG7, LOC105858493 (Tabula Microcebus)
○ (+) CD2, CD5, CD69, GZMB, TRAC (PanglaoDB)
○ 2-1. cytotoxic T cell (killer T cell, 세포 독성 T세포)
○ (+) IFNγ (IFNG), TNF, CD8, EOMES, CD8A, CD8B, Thy1.1, KLRG-1, GZMH, PRF1
○ (+) GZMK, CD8A, CD8B, MATK, DUSP5, GZMM, PTPRCAP, CTSW, ZAP70, DUSP2 (Tabula Sapiens)
○ (-) CD4
○ 2-2. CD8-positive effector t cell
○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, GNLY, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)
○ (+) GNLY, CEP78, KLRF1, NKG7, PTGDR, RP11-489E7.4, HIST1H1E, HIST1H1D, SAMD3, GZMM (Tabula Sapiens)
○ (+) GZMK, CD8B, CD8A, DUSP2, GZMM, CCL4, CMC1, CD3E, CCL5, CD69 (Tabula Sapiens)
○ (-) SELL, CCR7 (sc-type)
○ 2-3. memory CD8+ T cell
○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD45RO, CD6, CTLA4, IL2RA, GZMB, SELL, GNLY, S100A4, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)
○ (+) GZMK, SH2D1A, CD8A, CD8B, GZMM, DUSP2, CCL5, GZMA, CTSW, CMC1 (Tabula Sapiens)
○ 2-4. naïve CD8+ T cell
○ (+) CCR7
○ (+) CD8, CD2, CD3D, CD3E, CD3G, CD3Z, CD45RA, CD62L, CD27, CD127, FOXP3, CD45, CD8A, CD8B, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, SELL, GNLY, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)
○ (+) LYAR, FGFBP2, GZMH, MYBL1, KLRD1, GZMA, CD8A, CCL5, KLRG1, GNLY (Tabula Sapiens)
○ (-) CD25, CD44, CD69, HLA-DRA, CD95 (sc-type)
④ 종류 3. Treg cell (regulatory T cell, 조절 T 세포)
○ (+) CD4, CD25, CD127, CD152, TGFβ, IL-10, IL-12, FOXP3 (FoxP3), STAT5, IL2RA, CTLA4, TIGIT, IL1RL1, ICOS, TNFRSF9
○ (+) FOXP3, RTKN2, TIGIT, CTLA4, IL2RA, IKZF2, BATF, TRBV25-1, SPOCK2, CD28 (Tabula Sapiens)
○ (-) CD8A, CD8B
○ 3-1. naïve regulatory t cell
○ (+) TIGIT, CTLA4, CD5, ABCC1, PTPRCAP, ITK, SPOCK2, IKZF2, LEF1, RP4-765C7.2 (Tabula Sapiens)
⑤ 종류 4. gamma delta T cell (Tgd cell, γδ-T cell) : 일반적인 셀 타입인 alpha beta T cell과 비교됨. innate-like T cell 중 하나
○ (+) CD2, CD3D, CD3E, CD3G, CD3Z, CD25, CD45RA, CD62L, CD27, CD127, FOXP3, CCR7, CD45, CCR6, CD11b, CD30, CD6, CTLA4, IL2RA, GZMB, PTPRC, TRDV2, TRGV9, TRGC1, Trac, Ltb, Cd52, Trbc2, Shisa5, Lck, Thy1, Dapl1 (sc-type)
○ (+) GNLY, GZMB, FGFBP2, NKG7, PRF1, KLRF1, HOPX, CST7, KLRD1, CTSW, SPON2, GZMA, CD247, CD7, CCL5, TRDC (PanglaoDB)
○ (-) SELL, CCR7 (sc-type)
⑥ 종류 5. pro-T cell
○ 5-1. DN1 thymic pro-T cell
○ (+) GZMK, CCL4, SOCS1, PRDM1, TRBV25-1, CD2, KLRB1, CCL5, IL7R, TRAC (Tabula Sapiens)
⑦ 종류 6. DN T(double-negative T cell)
⑧ 종류 7. MAIT(mucosal-associated invariant T cell) : innate-like T cell 중 하나
○ (+) SLC4A10
⑨ 상태 1. activated T cell
○ (+) CD69, CD25
○ 1-1. early activation
○ (+) GZMK, GZMM, GZMA, NKG7
⑩ 상태 2. cytotoxic
○ (+) granzyme, perforin
⑪ 상태 3. naïve
○ (+) CD45RA, CD62L, CCR7, LEF1, SELL, TCF7, IL7R
○ (+) CD3D, SELL, CCR7 (PanglaoDB)
⑫ 상태 4. memory
○ (+) SELL, CD69, CD247, IL7R, CD3E, GIMAP4, CD2, PTPRC, TCF7, LTB, LCK, TRAC, CD3G, CD3D, TRBC2, CD7 (PanglaoDB)
○ 4-1. effector memory (EM)
○ (+) CD45, CD3, CD4, CD44, CD45RO
○ (-) CD62L, CCR7
○ 4-2. central memory (CM)
○ (+) CD45, CD3, CD4, CD44, CD62L, CD45RO, CD62L, CCR7
⑬ 상태 5. effector
○ (+) CD45RA
○ (-) CD62L, CCR7
⑭ 상태 6. experienced
○ (+) INPP5F, GPR25
⑮ 상태 7. progenitor exhausted
○ (+) TCF1/TCF7, PD-1, TIM-3
⑯ 상태 8. terminally exhausted
○ (+) Tox/Tox2, PDCD1 (PD-1), TIGIT, HAVCR2, LAG3, CTLA4, ENTPD1
⑰ 상태 9. immature
○ (+) Rag2, Arpp21, Rag1, A930003A15Rik, Dntt, Syt13, Capn3, Cd8a, Ccr9, Cd8b1 (Tabula Muris)
⑸ A-3. NKT cell (natural killer T-cell)
① (+) CD56, CD3
② 종류 1. type I NKT (iNKT)
○ (+) TCR, Va24, Vβ11
○ (+) CMC1, KLRB1, HIST1H1D, DUSP2, TXK, CD69, CD3E, CITED2, HIST1H1E, AREG (Tabula Sapiens)
③ 종류 2. type II NKT
④ 종류 3. mature NKT cell
○ (+) KLRF1, PRF1, FGFBP2, GNLY, IL2RB, GZMB, NKG7, SAMD3, CTSW, PYHIN1 (Tabula Sapiens)
○ (+) CCL5, IL32, LOC105874071, RPS27, RPL13A, GZMA, TMSB10, RPS11, LOC105881712, CST7 (Tabula Microcebus)
⑤ 종류 4. CD4+ NKT-like cell
○ (+) CD4, CD56, CD2, CD16, CD94, CD3D, CD3E, CD3G, CD3Z, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, COX6A2, ZMAT4, KIR2DL4 (sc-type)
⑥ 종류 5. CD8+ NKT cell
○ (+) CD8, CD56, CD2, CD16, CD94, CD3D, CD3E, CD3G, CD3Z, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, GNLY, COX6A2, ZMAT4, KIR2DL4 (sc-type)
⑹ A-4. natural killer cell (NK, 자연살상세포)
① pan-NK cell (일반적인 NK cell)
○ (+) NCAM1, NCAM2, FCGR3A, CD56, CD94, NKp46, KLRB1, KLRC1, KLRD1, KLRF1, KLRK1, NCR1, FCGR3B, KLRG-1, GNLY, CD244, PRF1, FCER1G, CD247
○ (+) NK1.1, CCL3, SLAMF6, NCR2, TNFRSF18, LAG3
○ (+) Klra8, Gzma, Klra23, Ncr1, Klra18, Ccl5, Gzmb, Cma1, Klra9, Klre1 (Tabula Muris)
○ (+) CCL5, GZMA, LOC105874071, IL32, TMSB10, NKG7, LOC105881712, CST7, LOC105881899, LOC105855163 (Tabula Microcebus)
○ (+) CD56, CD2, CD16, CD94, NKp46, CD11b, CD161, CD314, CD69, NKG7, CD122, NKG2D, GZMB, GZMA, GZMM, FCGR3A, GNLY, COX6A2, ZMAT4, KIR2DL4 (sc-type)
○ (+) CD69, KLRD1, GNLY, NKG7, IL32, GZMH, CTSW, CCL4, CD2, CCL5, GZMA, GZMB, DUSP2, CST7, CXCR4, S100A4, IL2RG, HOPX (PanglaoDB)
○ (-) CD3D, CD3E, CD3G, CD3Z, CD4, CD8 (sc-type)
② 종류 1. PB mature NK cell
○ (+) CD16
○ (-) CD56
○ 1-1. cytotoxic
○ (+) Granzyme, Perforin
③ 종류 2. PB immature / regulatory NK cell
○ (+) CD56, NCR
○ (-) CD16
④ 종류 3. CD3-negative NK cell : 더 일반적
○ (-) CD3
⑤ 종류 4. CD3-positive NK cell
○ (+) CD3
⑥ 상태 1. activated
○ (+) CD69
⑦ 상태 2. immature
○ (+) SCN1B, SNORD3B-1, RUNX2, CIDEB, TMIGD2, STAC, TNFSF4, BCAS1, PCDH9, TSIX (Tabula Sapiens)
⑺ A-5. nuocyte
⑻ B-1. granulocyte (과립세포)
① pan-granulocyte
○ (+) CD203c, CD15, CD11b, CD63, CD66b, CD123, CD16, CD33, CD117, CD45, Fc-epsilon RI-alpha, CD125, CD13, CD14, CD25, CD44, CD69, CD9, HLA-DR, CCR3, CD116, CD11c, CD193, CD24, CD32, CD43, CXCL8, FCGR3B, MNDA, SIGLEC8, AZU1, MPO, CTSG, LYZ (sc-type)
○ (+) MPO, AZU1, PRTN3, ELANE, MS4A3, CLEC11A, RNASE3, MKI67, TOP2A, UHRF1 (Tabula Sapiens)
○ (+) S100a8, S100a9, Krt81, Ngp, Camp, Lcn2, 1100001G20Rik, Ceacam10, Mmp8, Retnlg (Tabula Muris)
② 종류 1. basophil (호염기구) : 과립이 분산된 형태
○ (+) MS4A2, FcεR1α
○ (+) CD22, CD63, CD203c, CD123, CLC, MS4A3, TCN1, CPA3, HDC, GATA2, MS4A2, IL4, GCSAML, GATA2, TPSAB1 (sc-type)
○ (+) VWA5A, LTC4S, C1orf186, MS4A2, CPA3, TPSB2, HPGDS, TPSAB1, SLC18A2, KIT (Tabula Sapiens)
○ (-) CD19, CD45, CD117
○ 1-1. activated
○ (+) CD63, CD203c
③ 종류 2. eosinophil (호산구) : 과립이 2개의 덩어리 형성
○ (+) CD45, CD125, CD193, F4/80, Siglec-8, CD16
○ (+) CD11b, CD193, CD123, CD125, CD15, SIGLEC8, CLC, GATA1, CEBPE, SEMG1, ALOX15, CCL23, PRSS41, PRSS33, THBS4, FOXI1 (sc-type)
④ 종류 3. neutrophil (호중구) : 과립이 3개의 덩어리 형성
○ (+) CD11b, CD16, CD18, CD32, CD44, CD55, Ly6G, S100A8, S100A9, CSF3R, CD66b, CD15, SSEA1, NEAT1, CEACAM8
○ (+) CXCR1, CMTM2, MMP25, MGAM, CD177, PADI4, FCGR3B, MMP9, CXCR2, PROK2 (Tabula Sapiens)
○ (+) S100A12, S100A9, S100A8, CAMP, ACTB, LTF, TMSB4X, LCN2, RETN, PGLYRP1 (Tabula Microcebus)
○ (+) CD66b, CD11b, CD15, CD16, CXCL8, FCGR3B, MNDA, CXCR2, MPO, ELANE, PRTN3, MPO, AZU1, LYZ, S100A8, S100A9, PI3, CHI3L1, ANXA3, CXCL1, TGM3, BTNL3, C4BPA, MMP9, CD24, BPI, LTF, GCA, Camp, Ngp, Chil3, Ltf (sc-type)
○ (+) MPO, LYZ, ELANE, S100A8, PRTN3, AZU1, CTSG, SERPINB1, S100A4 (PanglaoDB)
○ 3-1. cd24 neutrophil
○ 3-2. nampt neutrophil
⑤ 종류 4. mast cell (비만세포)
○ (+) CD32, CD33, CD117, CD203c, FcεR1α, MS4A2, Tryptase, C5ar1
○ (+) CD117, CD203c, CD25, KIT, SLC18A2, CD33, CD32, FCER1A, TPSD1, HPGDS (sc-type)
○ (+) HDC, TPSAB1, TPSB2, CPA3, MS4A2, C1orf186, HPGDS, KIT, SLC18A2, VWA5A (Tabula Sapiens)
○ (+) KIT, CPA3, TPSAB1, IL1RL1, RGS1, HDC, TPSB2, RGS13, MS4A2, VWA5A, HPGDS, DUSP1 (PanglaoDB)
○ (+) CPA3, CMA1, CTSG, SIGLEC6, MS4A2, HDC, PRG2, SLC18A2, TAL1, TPSAB1, SIGLEC8, HPGDS, AMHR2, LAX1, NDST2 (SCEVAN)
○ 4-1. activated
○ (+) CD203c
⑥ 종류 5. granulocytopoietic cell
○ S100a8, S100a9, Camp, Ngp, Fcnb, Lcn2, Chi3l3, 1100001G20Rik, Cebpe, Ltf (Tabula Muris)
⑼ B-2. dendritic cyte (DC, 수지상세포)
① pan-dendritic cell
○ (+) IL3RA, CD1C, BATF3, THBD, CD209, CD11C, HLA-DR, CLEC4C, NRP1, FCER1A, CD14, ETV6, CD80, CD86, ADGRE5, IL2RG, LILRA4
○ (+) IFNa, BTLA, CADM1, ITGAE, LY75, CLEC4K, CD1B
○ (+) CD86, CPVL, HLA-DPB1, HLA-DPA1, HLA-DQB1, HLA-DMB, HLA-DMA, CXCL16, HLA-DRA, YWHAH (Tabula Sapiens)
○ (+) TMSB4X, CD74, LOC105869751, LOC105872012, CST3, LOC105876793, TMSB10, RPS27, IFI30, LOC105869753 (Tabula Microcebus)
○ (+) S100A9, HLA-DRA, HLA-DQA1, HLA-DMA, HLA-DQB1, HLA-DRB1, HLA-DPA1, HLA-DPB1, S100A4, CLEC7A, AIF1, LST1, CTSS, PTPRC, FTL, ANXA1, LGALS3, H2AFY, HLA-A, HLA-B, HLA-C (PanglaoDB)
② 종류 1. activated dendritic cell (aDC)
③ 종류 2. immature dendritic cell (iDC)
④ 종류 3. liver dendritic cell
○ (+) HLA-DRB5, SNRPGP14, HLA-DQA1, FCER1A, P2RY6, HLA-DQB1, S100B, RAB7B, CLEC10A, RP11-242C19.2 (Tabula Sapiens)
⑤ 종류 4. mature conventional dendritic cell
○ (+) IDO2, FSCN1, CCL22, GPR157, TVP23A, IDO1, WFDC21P, TBC1D8, LAMP3, EBI3 (Tabula Sapiens)
⑥ 종류 5. myeloid dendritic cell
○ (+) ITGAX, CD83, CD1C, NRP1, CLEC4C, CD86, IL3RA, CD80, CD1A, ITGAX, CD40, HLA-DQA1, CD11c, HLA-DR, HLA-DPB1, HLA-DPA1, CLEC10A, CST3, GPR31, ODF3L1, PRB2, CD207, ARSE, CLEC141, MRC, EBLN1, CRIP3 (sc-type)
○ 5-1. cd1c-positive myeloid dendritic cell
○ (+) MRPS6, C15orf48, KYNU, HLA-DQA2, VMO1, EPB41L3, IL4I1, TFRC, GK, AGPAT9 (Tabula Sapiens)
○ 5-2. cd141-positive myeloid dendritic cell
○ (+) LGALS2, WFDC21P, CPVL, C1orf54, EBI3, BATF3, CLIC2, ADRBK2, HLA-DQA1, FLT3 (Tabula Sapiens)
⑦ 종류 6. oligodendrocyte (희소돌기아교세포)
⑧ 종류 7. plasmacytoid dendritic cell (pDC) : rare한 DC 서브타입. blood에서의 면역작용에 관여하고 인터페론1을 과량 분비. IFN-α를 분비하여 T 세포를 활성화하지만, T 세포의 확장을 억제하기 위해 그란자임 B를 분비
○ (+) SIGLECH, KLK1, HLA-DR, IL3RA (CD123), IRF8, TCF4 (E2-2), SPI1 (PU.1), FLT3L
○ (+) ITGAX, CD83, CD1C, NRP1, CLEC4C (BDCA-2), CD86, IL3RA, CD80, CD1A, ITGAX, CD40, HLA-DQA1, CD11c, HLA-DR, HLA-DPB1, HLA-DPA1, CLEC10A, CST3, TPM2, LRRC26, ASIP, GPM6B, KRT5, NTM, SCT, SHD, KCNA5, SCARA5, EPHA2, MYMX (sc-type)
○ (+) IRF7, SLC15A4, PLD4, LAMP5, IRF4, RUNX2, GZMB, BCL11A, CHAF1A, ADA (Tabula Sapiens)
○ (+) LILRA4, GPR183, PTCRA, FAM129C, SPIB, GZMB, CXCR4, IRF7, IRF8, JCHAIN, SERPINF1, ITM2C, TCF4, BCL11A, MZB1, DERL3, NRP1 (PanglaoDB)
○ 7-1. activated
○ (+) CD83
⑨ 종류 8. conventional DC (cDC) : innate immune cell 중 하나
○ (+) CD11c, HLA-DR
○ 8-1. cDC1 (excel at cross-presentation)
○ (+) XCR1, CLEC9A
○ 8-2. cDC2
○ (+) CD1C, SIRPα, CLEC10A
○ 상태 1. activated
○ (+) CD83
⑩ 종류 9. functoinally defective DC
⑪ 종류 10. regulatory DC(regDC; tolerogenic DC; tDC)
○ (+) MHC II, CD11b, CD11c, PD-1, B7-H1
○ 10-1. CD83highCCR7+ IL-10DC
○ 10-2. CD83lowCCR7- IL-10DC
⑫ 종류 11. langerhans-like DC (LanghDC)
⑬ 종류 12. migratory DC (migDC)
⑭ 종류 13. AXL+SIGLEC6+ DC (ASDC)
⑽ B-3. macrophage (대식세포)
① pan-macrophage
○ (+) CD11b, CD68, CD163, ADGRE1, ITGAM, CSF1R, CD14, FCGR3A, Cd74, Arg1, CD80, CD86, CXCL5, APOC1, BASP1, FAM49A, GJB2, LPXN, LY86, MAP3K8, MNDA, PLD4, PPARG, SEC24A, SERPINB9
○ (+) IL1a, IFNb2, CDF, BSF1, BCGF1, TGIF, CSIF, IL13, P600, CSFR, CLEC13D, M130, PDL2, B7DC, RETNLB, CCR2, CSF1, CLEC6A, ITGB2, PDCD1LG2, CSF2
○ (+) MARCO, ACP5, OLR1, PLTP, SLCO2B1, MS4A4A, C1QC, MSR1, FBP1, MRC1 (Tabula Sapiens)
○ (+) Cd300c, Siglech, Apol7c, Gm8221, H2-M2, Cox6a2, Lilra5, Atp2a1, Cd209g, Cd209f (Tabula Muris)
○ (+) FTL, FTH1, LOC105882215, CD74, TMSB4X, APOE, CST3, LOC105869751, C1QA, SPP1 (Tabula Microcebus)
○ (+) CD68, CD163, CD14, CD11b, CD206, CD80, CD86, CD16, CD64, CCL18, CD115, CD11c, CD32, HLA-DR, MRC1, MSR1, GCA, Pf4 (sc-type)
○ (+) ITGAM, FCGR3A, LILRB4, TREM2, CXCL16, CD83, RBPJ, GPNMB, VSIG4, MS4A4A, C5AR1, CCL2, S100A4, NRP2, CD36, MS4A7, CLEC7A, CD74, CSF1R, LGALS3, CYBB, ITGAX, TYROBP, DAB2, MAF, AIF1, CYP27A1, SLC7A7 (PanglaoDB)
○ (+) CD68, CD163, MS4A4A, CYBB, FCER1G, CLEC5A, MS4A6A, HK3, MSR1, IGSF6, CHIT1, DNASE2B, FDX1, SLAMF8, VSIG4 (SCEVAN)
○ (-) CD56, CD11c
② 종류 1. M1 대식세포
○ (+) iNOS, IL-6, CD86, CD80, CD68, MHCII, IL-1R, TLR2, TLR4, SOCS3, ITGAX (CD11c), CD16, FCN1, HLA-DR, pSTAT1, IL-12, MHC-II, CD80, 27E10, CCL2, S100A8, S100A9, CXCL9, CXCL10
③ 종류 2. M2 대식세포
○ (+) MRC1, CD163, CD204, CD206, VEGF, cMAF, ARG1, YM1, CCL20, CCL22, 1IDO1
○ 2-1. M2a
○ (+) CD163, SR, CD206, CD200R, TGM2, DecoyR, IL-1R II, Fizz1, Arginase-1, MHCII
○ 2-2. M2b
○ (+) CD86, MHCII
○ 2-3. M2c
○ (+) CD163, TLR1, TLR8
○ 2-4. M2d
○ (+) VEGF
○ 2-5. TAM
○ (+) CCL2, CD3, CD31, CD68, CD163, HLA-DR, iL-10, iNOS, PCNA, VEGF
○ 2-6. TCR-positive
○ (+) CD68, Fyn, LAT, Lck, ZAP70
○ 2-7. CD169-positive
○ (+) CD11b, CD11c, CD68, F4/80, MHCII
④ 분류 1. bone-marrow-derived macrophage (BMDM)
⑤ 분류 2. dust cell
⑥ 분류 3. Kupffer cell (쿠퍼 정상세포)
○ (+) CD14, CD68, TNF, LYZ, MPO, VSIG4, PROK2, STARD5, MSR1, PPARA, TREM1, SLC11A1, MMP13, VDR, CHIT1, OSM, PPARD, CLEC4F, ADGRE1, IL1B, SLC40A1, G6PD, TIMD4, MNDA, SLC15A3, DNASE1L3, MARCO, HFE, CD38, CD163, CCR5, CLEC1B, CLEC4G, GPIHBP1, FOLR2, PLTP, FTL, IRF7, SPIC, CSF1R, C1QC, C1QA, C1QB, CLEC4E (sc-type)
○ (+) CLEC4F, ID3, ZEB2, LXRα
⑦ 분류 4. microglial cell
○ (+) BHLHE41, SLC2A5, HAMP, FCGR1A, SLC1A3, AP1B1, B3GNT5, HAVCR2, LILRB4, CSF1R (Tabula Sapiens)
○ (+) NAIP, CX3CR1, P2RY12, CCR1, FGD2, FCGR2A, DOCK8, TREM2, FOLR2, ADAM28, C1QC, P2RY13, C1QA, CD68, C1QB (SCEVAN)
○ 4-1. eye microglial cell
○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1, CX3CR1, CX3CL1 (sc-type)
○ 4-2. brain microglial cell
○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1 (sc-type)
○ (+) IBA1, Cd68, TMEM19, P2RY12, SALL1
⑧ 분류 5. splenocyte
⑨ 분류 6. immunosuppressive macrophage
○ (+) CD163, MSR1
⑩ 분류 7 . TIM4+ perivascular macrophage
○ (+) TIM4, LYVE1, FOLR2, cMAF
○ (-) MHCII
⑪ 분류 8. MHCII+ Perivascular Macrophage
○ (+) MHCII, cMAF
○ (-) TIM4, LYVE1
⑫ 상태 1. aged macrophage
○ (+) Cd274, Clec4d
○ (-) Coro1a
⑾ B-4. monocyte (단핵구)
① (+) CD14, FCGR1A, CD68, S100A12, NR4A1, CD4, CD11C, HLA-DR
② (+) FOLR3, TCIRG1, RP11-1143G9.4, RNASE2, SULT1A1, FCN1, CD300E, PRAM1, ARHGAP4, C19orf38 (Tabula Sapiens)
③ (+) Lyz2, Lyz1, Galnt9, Ms4a8a, Apoc2, Gm9733, Ms4a6c, Ccr2, Ccl9, Ccl6 (Tabula Muris)
④ (+) FTH1, SOD2, TMSB4X, CCL15, LGALS1, CD74, S100A4, PGLYRP1, CXCL8, FTL (Tabula Microcebus)
⑤ (+) OAS1, IRF7, PLSCR1, MX1, HLA-DRA, IFIT1, IFIT3, TNFSF10, S100A9, S100A4, CD44, PTPRC, PSAP (PanglaoDB)
⑥ (-) CD206, CD86
⑦ 종류 1. classical monoctye (C monocyte)
○ (+) CD14, S100A8, S100A9
○ (+) CD14, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, VCAN, S100A12, CXCL8, S100A8, S100A9, LYZ, CST3, Elane1 (sc-type)
○ (+) FLT3, TMEM170B, IFI30, RNASE2, FCN1, ADAMTS2, EMILIN2, CD33, SH3BP2, SLC43A2 (Tabula Sapiens)
○ (-) CD56, CD16 (=FCGR3A) (sc-type)
⑧ 종류 2. non-classical monocyte (N monocyte)
○ (+) FCGR3A (CD16), CDKN1C, MTSS1
○ (+) CD16, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, FCGR3A, CDKN1C, LST1, FCER1G, MS4A7, RHOC, S100A8, S100A9, CST3, C1QC, Elane1 (sc-type)
○ (+) LRRC25, CSF1R, LILRB2, FCGR3A, CD86, LST1, MS4A6A, CLEC7A, C3AR1, MS4A4A (Tabula Sapiens)
○ (-) CD14
○ (-) CD56 (sc-type)
⑨ 종류 3. intermediate monocyte (I monocyte)
○ (+) CD14, CD16, CD11b, CD68, HLA-DR, CD33, CD11c, CD123, CD15, CD3D, CD3G, CD3Z, CD66b, IL1B, S100A8, S100A9, CST3, C1QC, Elane1 (sc-type)
○ (+) FBXL5, BID, CD300E, FGL2, MPEG1, RNASE2, C3AR1, LILRB2, CYBB, MS4A6A (Tabula Sapiens)
○ (-) CD56 (sc-type)
⑿ B-5. MDSC(myeloid-derived suppressor cell)
① (+) Gr-1, CD11b
② 종류 1. eMDSC(early-stage MDSC)
○ (+) CD33
○ (-) HLA-DR, Lin
③ 종류 2. PMN-MDSC (polymorphonuclear MDSC)
○ (+) ITGAM (CD11b), CD33, CD15, CEACAM8 (CD66b), Ly6G
○ (-) CD14, Ly6C, HLA-DR
○ (low) Ly6C
④ 종류 3. M-MDSC (monocytic MDSC)
○ (+) ITGAM (CD11b), CD33, CD14
○ (-) HLA-DR, CD15, Ly6C, Ly6G
○ (low) HLA-DR
○ (high) Ly6C
⒀ 대분류 2. erythrocyte (erythroid, 적혈구)
① (+) Hbb-bt, Hbb-bs, Hba-a2, Hba-a1, Car2, GATA1
② (+) ALAS2, HBQ1, HBM, EPB42, HBB, HBD, HBA1, HBA2, SLC4A1, TRIM58 (Tabula Sapiens)
③ 종류 1. erythroblast
④ 종류 2. erythroid-like and erythroid precursor cells
○ (+) ALAS2, HBB, HBA1, HBA2, GYPB, AHSP, HBM, FECH, BPGM, HBD, HEMGN, HMBS, NCOA4, SLC4A1, SLC25A39, SLC25A37, EPB42,GYPC, SNCA (PanglaoDB)
⑤ 종류 3. reticulocyte
⒁ 대분류 3. megakaryocytes (거핵세포) : 골수에서 혈소판 생성
① (+) CD61, CD41, CD42b, CD41a, CD42a, CXCR4, CD110 (sc-type)
② 종류 1. platelet (혈소판)
○ (+) CD41, CD42b, CD61, CD31, PPBP, PF4, GNG11, SDPR, CLU, CD41, CD110 (sc-type)
○ (+) RUFY1, NRGN, LY6G6F, PRKAR2B, MTURN, MMD, TSPAN33, PF4, CTSA, GP9 (Tabula Sapiens)
○ (+) CCL5, ITGA2B, PF4, F13A1, GP9, NCOA4, RGS18, PPBP, TREML1, CD9, NRGN, OST4, SPARC, GPX1, CAVIN2, PPDPF, MYL9, MAP3K7CL, GNG11, GRAP2, MPIG6B, ARHGDIB, CDKN2D, HLA-A, PDLIM1, SRGN (PanglaoDB)
⒂ 대분류 4. progenitor (전구세포)
① common lymphoid progenitor (CLP)
○ (+) CD34, CD38, CD10, CD45RA
② common myeloid progenitor (CMP)
○ (+) CD34, CD38, CD135
○ (+) RP11-620J15.3, PRSS57, DPPA4, CYTL1, GATA1, KLF1, RP11-354E11.2, AC002454.1, MYB, SPTA1 (Tabula Sapiens)
○ (-) CD7, CD10, CD45RA, CD90/Thy1
③ early progenitor
○ (+) Epha5, Tcf4, Erbb4
④ erythroid lineage cell
○ (+) GMPR, SLC25A39, HBA2, HBA1, HBB, HBQ1, SNCA, HBD, ALAS2, CA1 (Tabula Sapiens)
○ (+) LOC105883507, LOC105856254, AHSP, GPX1, PRDX2, LOC105856252, CA2, LOC105856255, RPS12, BLVRB (Tabula Microcebus)
⑤ erythroid progenitor
○ (+) Ter119
○ (+) FAM178B, RHAG, KLF1, SPTA1, GATA1, GFI1B, KCNH2, KEL, RP11-620J15.3, CA1 (Tabula Sapiens)
○ (+) LOC105883507, RPS18, RPS12, ZC3H10, RPLP1, RPL13, RPS20, RPS5, RPL10, RPS14 (Tabula Microcebus)
○ (+) PTPRC, GYPA (CD235a), RUVBL1, TFRC (CD71), FOLR1, CD36, ITGA4, HBB, CD235a, HBD, CA1 (sc-type)
⑥ granulocyte-monocyte progenitor (GMP)
○ (+) CD34, CD38, CD45RA, CD123, CD135
○ (-) CD10
⑦ hematopoietic stem cell (HSC)
○ (+) CD34, CD45, CD49, CD90/Thy1, Cd150, Vcam1
○ (+) PRSS57, AVP, CRHBP, DPPA4, PINK2, CYTL1, MYB, KIAA0125, MLLT3, RP11-620J15.3 (Tabula Sapiens)
○ (+) Ctsg, Mpo, Prtn3, Elane, Nkx2-3, Ms4a3, Kcnk12, Prss57, Muc13, Bex6 (Tabula Muris)
○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31, Nestin, OCT4, CD117, KDR, CXCL8, AVP, CRHBP, ALDH1A1, CD49, CD90, CD69, CD24, CD45RA, Keratin-19, ASPM, CD10, CD123, ABCG2, CD135, CD49f, EpCAM, Keratin-7, SCA-1, CD14, CD150, CD271, HLA-DR (sc-type)
○ (-) CD38, CD45RA, Cd127, Cd135, PTPRC
⑧ megakaryocyte–erythroid progenitor (MEP)
○ (+) CD34, CD38
○ (-) CD7, CD10, CD45RA, CD135, IL3Rα
⑨ mesenchymal stem cell (MSC)
○ (+) VIM (vimentin), Vim
○ (+) THBS4, SMOC2, LINC01088, BMPER, GFRA1, PQLC2L, CILP, LAMA2, NEGR1, VGLL3 (Tabula Sapiens)
○ (+) Ifi205, Ptx3, Ccl11, Lrrn4cl, Saa1, Tnfaip6, Scg3, Stmn4, D630033O11Rik, Mt2 (Tabula Muris)
○ (+) GSN, DCN, LOC105866476, APOD, IGFBP3, JUNB, LOC105866554, EGR1, FOS, CHIT1 (Tabula Microcebus)
○ 종류 1. mesenchymal cell
○ (+) Hao1, 3110079O15Rik, Ucma, Col9a1, Wif1, Mia1, Hapln1, Lect1, Clec3a, Acan (Tabula Muris)
⑩ multi-potent progenitor (MPP)
○ (+) CD34
○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31, Nestin, OCT4, CD117, KDR, CXCL8, AVP, CRHBP, ALDH1A1, CD49, CD90, CD69, CD24, CD45RA, Keratin-19, ASPM, CD10, CD123, ABCG2, CD135, CD49f, EpCAM, Keratin-7, SCA-1, CD14, CD150, CD271, HLA-DR (sc-type)
○ (-) CD38, CD45RA, CD90/Thy1, PTPRC
⑪ plasmablast
○ (+) Cd38, MHC class II, CD27, CD38, CD80
○ (+) ZNF587P1, CTD-2031P19.4, MTND5Pp11, AC074289.1, ZWINT, RP11-380M21.2, CDC42P6, PHTF1, RNU4-1, CEP128 (Tabula Sapiens)
⑫ progenitor cell
○ (+) CD105, CD34, CD44, CD73, CD45, CD29, STRO-1, NANOG, SOX2, CD133, CD166, CD146, CD31 (PECAM1), Nestin, OCT4, CD117, KDR, AVP, CRHBP, ALDH1A1, STMN1, CD38, PTPRC, CD135 (sc-type)
⒃ 조직 1. PBMC(peripheral blood mononuclear cell)
⒄ 조직 2. BALF(bronchoalveolar lavage fluid)
⒅ 조직 3. 암(tumor)
① tumor infiltrating lymphocyte (TIL)
○ (+) CD45, CD3
⒆ 조직 4. pancreatic immune cell
① immune system cell
○ (+) MS4A1, CD19, CD4, CD8A, CD7, CTLA4, CD27, CCR7, CYTIP, IGHD, CD38, IL2RA, ISG20, SELL, IL7R, FOXP3, IGKC, IGLC3, IGLC2, CD79A, CD68, CD163, CD14, ITGAM, MRC1, MS4A7, CD3D, CD3E, CD3G (sc-type)
② mast cell
○ (+) KIT, ENPP3, IL2RA, ISG20, SLC18A2, CD9, FCER1A, TPSB2, FCER2 (sc-type)
③ mesenchymal cell
○ (+) ITGB1, NT5E, THY1, ENG, KIT, ALCAM (sc-type)
④ pancreatic progenitor cell
○ (+) ONECUT1, PDX1, PTF1A, CXCR4, ISL1, NKX2-2, EPAS1, ARX, NEUROG3, SOX9, RPL23A, CTNNB1, YAP1, RGS16, MFNG (sc-type)
⑤ pancreatic stellate cell
○ (+) TIMP1, RGS5, SPON2, GEM, DYNLT1, PDGFRB, KRT10, CYGB, CCN2, MMP14, NDUFA4L2, PDGFRA, INHBA, TGFB1 (sc-type)
○ (+) SNRPE, FAM162B, CDK4, NGFR, SEPT4, PTH1R, HEYL, ARHGAP42, ARHGEF17, SYDE1 (Tabula Sapiens)
○ (+) TIMP1, SPON2, GEM, DYNLT1, PDGFRB, KRT10, MMP14, NDUFA4L2, COL6A1, FN1, COL4A1, COL6A2, MGP, COL3A1, SPARC, COL1A1, TIMP3, TNFAIP6, COL1A2, SFRP2, COL6A3, THY1 (PanglaoDB)
⑥ peri-islet Schwann cell
○ (+) MPZ, EGFL8, GFRA1, OLFML2A, GULP1, SLITRK6, VGLL3, GFRA3, INSC, SLITRK2, FIGN, LRRTM1, SEMA3B, NGFR, PNLIPRP1, GFRA2 (sc-type)
○ (+) MPZ, OLFML2A, GULP1, GFRA3, INSC, SLITRK2, FIGN, SEMA3B, NGFR (PanglaoDB)
⒇ 조직 5. liver immune cell
① immune system cell
○ (+) CD19, MS4A1, IL2RA, PTPRC, CD4, CD8A, CD3D, CD3E, CD3G, CD11c, CD14, CD16, CD56, CD16, CD42b, CD7, CD8, IgD, CD38, CD24, CD20, CD14, CD16, HLA-DR, CD11b, CD11c, CD123, CD15, CD33, CD66b, CD27, CD94, CD45 (sc-type)
② Kupffer cell
○ (+) CD14, CD68, TNF, LYZ, MPO, VSIG4, PROK2, STARD5, MSR1, PPARA, TREM1, SLC11A1, MMP13, VDR, CHIT1, OSM, PPARD, CLEC4F, ADGRE1, IL1B, SLC40A1, G6PD, TIMD4, MNDA, SLC15A3, DNASE1L3, MARCO, HFE, CD38, CD163, CCR5, CLEC1B, CLEC4G, GPIHBP1, FOLR2, PLTP, FTL, IRF7, SPIC, CSF1R, C1QC, C1QA, C1QB, CLEC4E (sc-type)
○ (+) CLEC4F, ID3, ZEB2, LXRα
③ liver progenitor cell
○ (+) KRT7, KRT19 (sc-type)
④ mast cell
○ (+) KIT, ENPP3, IL2RA, ISG20, SLC18A2, CD9, FCER1A, TPSB2, FCER2 (sc-type)
⑤ mesenchymal cell
○ (+) CD44, ENG, NT5E, ITGB1, THY1 (sc-type)
⑥ monocyte
○ (+) FCGR3A, FCGR3B, CD14, Elane1 (sc-type)
⒇ 조직 6. eye immune cell
① microglial cell
○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1, CX3CR1, CX3CL1 (sc-type)
② eye immune cell
○ (+) CD25, CD69, CD4, CD3, ITGAM, C1qa, Fcer1g, CD19, CD20, Trac, Ltb, Cd52, Trbc2 (sc-type)
⒇ 조직 7. kidney immune cell
① immune cell
○ (+) CD19, IGHA2, IGHG3, IGHM, IGKC, JCHAIN, CD40, CD79A, CPNE5, FCRL5, HLA-DRA, IGHA1, IGHG1, IGHG2, IGKV1-12, IGLC2, IGLC3, IGLC7, IGLL5, MS4A1, MZB1, PKHD1L1, PNOC, POU2AF1, TNFRSF13C, CD3D, TRAC, IL7R, CD3E, CD8A, TRBC2, CD52, FCGR3A, IL32, KLRD1, CD68, CXCL8, FCGR3B, MNDA, KIT, PTGS2, SLC18A2, Trac, Ltb, Cd52, Trbc2, Shisa5 (sc-type)
② hematopoietic cell
○ (+) CORO1A, MNDA, SRGN, HLA-DPA1, LST1 (sc-type)
⒇ 조직 8. brain immune cell
① immune system cell
○ (+) MS4A1, CCR6, CXCR3, CD4, IL2RA, ISG20, TNFRSF8, Trac, Ltb, Cd52 (sc-type)
② microglial cell
○ (+) P2RY12, ITGAM, CD40, PTPRC, CD68, AIF1, CX3CR1, TMEM119, ADGRE1, C1QA, NOS2, TNF, ISYNA1, CCL4, ADORA3, ADRB2, BHLHE41, BIN1, KLF2, NAV3, RHOB, SALL1, SIGLEC8, SLC1A3, SPRY1, TAL1 (sc-type)
○ (+) IBA1, Cd68, TMEM19, P2RY12, SALL1
⒇ 조직 9. lung immune cell
① alveolar macrophage
○ (+) HLA-DR, CD169, CD206, SIGLECF, CD11c, PPARγ, C/EBPβ
○ (+) FTH1, FTL, TMSB4X, TYROBP, C1QA, RPLP1, LGALS3, CTSD, ACTB, RPS18 (Tabula Miceocebus)
○ (+) ABCG1, CCL3, CD36, CLEC7A, CSF2RB, CXCL2, G0S2, GAL, GDA, GNGT2, GPNMB, IL18, IL1B, ITGAX, KLHDC4, MARCO, MCEMP1, MPP1, MRC1, OLR1, PLET1, S100A4, TLR2, TNFAIP2, TRIM25 (sc-type)
② interstitial macrophage
○ (+) HLA-DR, CD206
○ (-) CD169
③ immune system cell
○ (+) ADGRE1, ARG1, BIRC5, CCL17, CCL18, CD14, CD163, CD19, CD22, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD68, CD74, CD80, CD83, CD86, CD8A, CD8B, CDCA3, CDK1, CEBPE, CR2, CSF1R, EAF2, FCER2, FCGR3A, FLT3, GIMAP3P, HLA-DRA, HMMR, IGHM, IL2RA, ITGAE, ITGAM, ITGAX, LAX1, MS4A14, MZB1, NRP1, NUSAP1, PAX5, PRG2, PTPRC, SLPI, THBD, TNFRSF17, TRBC1, XCR1 (sc-type)
⒇ 조직 10. adrenal immune cell
① myeloid cell
○ (+) MS4A14, LILRA1, RP11-554D14.6, AC007040.8, MS4A7, RP11-489O18.1, CLEC10A, MS4A4A, RN7SL138P, CD163, CD14, SIGLEC1, VSIG4, CLEC7A, LILRA2 (sc-type)
② erythroblast
○ (+) TPSAB1, CTD-2008P7.9, RP11-85G21.3, CTSE, CTA-392E5.1, EIF5AP2, CTA-363E6.6, C17orf99, SLC4A1, TRIM10, MIR144, ART4, AHSP, GYPA, HBM (sc-type)
③ lymphoid cell
○ (+) GZMH, XCL1, KLRC3, RP11-94L15.2, GZMA, IL2RB, TRAT1, SH2D1A, DTHD1, CD3E, ZNF831, GNLY, PRF1, IGHD, THEMIS (sc-type)
⒇ 조직 11. heart immune cell
① lymphoid cell
○ (+) GZMB, FCRL2, KLRC2, XCL1, LINC00861, PRF1, CD3G, SH2D1B, ANTXRLP1, VPREB3, SH2D1A, CRTAM, CXCR6, RP11-94L15.2, GZMK (sc-type)
② myeloid cell
○ (+) XCR1, TMPRSS4-AS1, TIMD4, PRTN3, MMP9, CD86, CLEC5A, SIGLEC1, CLEC7A, C1QC, P2RY13, FCN1, CSTA, CD300LF, MS4A6A (sc-type)
③ erythroblast
○ (+) RP5-857K21.7, CENPW, SLC46A1, GSPT2, RHCE, SLC7A11, P2RX6, SKA1, FARSA, ZNF90, TMCC2, RP11-225B17.2, TMEM161A, ZNF583, ENPP4 (sc-type)
⒇ 조직 12. intestine immune cell
① erythroblast
○ (+) AHSP, SPTA1, HBG2, HBA2, HBM, HBG1, HBA1, SLC4A1, HBB, GYPA, HEMGN, HBZ, ALAS2, MIR144, MYL4 (sc-type)
② myeloid cell
○ (+) VSIG4, RPL32P1, CD207, AP000439.1, HCAR3, C5orf20, AC010492.4, P2RY13, LILRB2, LILRB5, IL1B, C1QB, CD163, C1QC, DNASE1L3 (sc-type)
③ lymphoid cell
○ (+) IL17A, ICOS, SH2D1A, GZMK, RP11-553L6.2, TRGC1, RP11-104L21.3, TRDC, GZMA, VPREB1, CCR4,LTA, NCR2, CD247, RP11-94L15.2 (sc-type)
⒇ 조직 13. muscle immune cell
① 종류 1. erythroblast
○ (+) RHAG, GYPA, AHSP, GYPB, HBZ, ALAS2, SLC4A1, SLC14A1, EIF5AP2, HBM, HBA1, EPB42, RP11-57H12.2, ALS2CR12, SLC25A37 (sc-type)
② 종류 2. myeloid cell
○ (+) FCN1, MS4A4E, TMPRSS4-AS1, CD86, FLT3, P2RY13, IL10RA, FOLR2, MNDA, HLA-DQB1, MS4A4A, AMICA1, CYTH4, MS4A6A, CFP (sc-type)
③ 종류 3. lymphoid cell
○ (+) IL7R, CD8A, NKG7, CD247, NCR1, RP11-61O1.1, TRAC, CD3E, ITK, CD2, MATK, RP11-444A22.1, SYTL1, IL2RB, GZMA (sc-type)
⒇ 조직 14. placenta immune cell
① 종류 1. lymphoid cell
○ (+) IGJ, IGHM, KLRC3, GZMH, PTGDR, IGHGP, IKZF3, IFNG-AS1, TIGIT, KLRC2, LCK, ANKRD36BP2, TNFRSF18, IGHG3, LINC00861 (sc-type)
② 종류 2. myeloid cell
○ (+) SIGLEC10, RP11-1143G9.4, LYZ, ADAMDEC1, LILRB2, HLA-DRB5, SDS, HLA-DOA, SIGLEC1, MMP9, LILRB4, C1QB, TLR2, TLR7, S100A8 (sc-type)
⒇ 조직 15. spleen immune cell
① 종류 1. lymphoid cell
○ (+) RN7SL337P, KLRC4-KLRK1, RP11-553L6.2, RP11-861A13.4, RP11-38J22.6, ZNF860, RP11-693J15.5, RP11-61O1.1, FCRL3, CTD-2215E18.1, RP5-1028K7.2, IKZF3, LINC00861, IL9RP3, VAV3-AS1 (sc-type)
② 종류 2. myeloid cell
○ (+) CLEC9A, RP11-489O18.1, RP3-522P13.3, RP11-807H22.7, RP11-1080G15.1, FCN1, EMR4P, TMPRSS4-AS1, RP11-157G21.2, CSF2RA, OSCAR, RP3-522D1.1, CD163L1, RUFY4, DLEU7-AS1 (sc-type)
③ 종류 3. erythroblast
○ (+) HDC, PRSS57, EIF5AP2, PPAPDC1A, MTL5, CTA-392E5.1, ACSBG1, RP5-964N17.1, GYPA, SLC25A21, RP11-146I2.1, MIR144, SLC2A14, CTA-363E6.6, SLC4A1 (sc-type)
④ 종류 4. white pulp macrophage
○ (+) CD68
○ (-) F4/80
⑤ 종류 5. marginal zone macrophage
○ (+) SIGN-R1, LXRα
⑥ 종류 6. red pulp macrophage
○ (+) VCAM1, Spi-C
○ (-) CD11b
⒇ 조직 16. stomach immune cell
① 종류 1. erythroblast
○ (+) KLF1, SLC4A1, HBM, NFE2, HBZ, GYPB, HBG2, HBB, ALAS2, SPTA1, HBA1, HEMGN, RNF224, HBG1, HBA2 (sc-type)
② 종류 2. myeloid cell
○ (+) C1QC, HLA-DQB1, MS4A6A, CD14, C1QB, CD163L1, IGSF6, CCDC26, C1QA, NCF2, HLA-DRB1, HLA-DRB5, CLEC7A, MS4A7, HLA-DPA1 (sc-type)
③ 종류 3. lymphoid cell
○ (+) ICOS, CD27, NKG7, CD28, CD3D, CHI3L2, TRAT1, THEMIS, CD52, KLRB1, CD79B, CCL5, TRBC2, SIRPG, CD3E (sc-type)
⒇ 조직 17. thymic immune cell
① 종류 1. antigen presenting cell
○ (+) IL1RN, EBI3, FGD2, MCOLN2, MMP9, TLR10, LINC00996, CD80, CXCL10, SLAMF7, P2RY13, SLC24A4, HCK, C1QB, LYZ (sc-type)
⒇ 조직 18. bladder immune cell
① 종류 1. B cell
② 종류 2. macrophage
③ 종류 3. mast cell
④ 종류 4. NK cell
⑤ 종류 5. plasma cell
⑥ 종류 6. plasmacytoid dendritic cell
⑦ 종류 7. T cell
5. 유형 4. stromal cell (기질세포) [목차]
⑴ 개요 : pan-stromal cell
① (+) Slc7a10, Slc38a5, Slc36a2, Adrb3, Scn3a, C7, Prkg2, A330076H08Rik, Inmt, Foxf2 (Tabula Muris)
② (+) DCN, PAPPA, SFRP4, THBS2, LY86, CXCL14, FOXF1, COL10A1, ACTG2, APBB1IP, SH2D1A, SULF1, MSR1, C3AR1, FAP (SCEVAN)
⑵ 조직 1. connective tissue
① 종류 1. adipocyte
○ (+) ADH1B, ADIPOQ, ANKRD29, CAVIN2, CLEC14A, EGFL7, HOXD8, HOXD9, KDR, LPL, MMRN2, NOSTRIN, PDCD1LG2, PDE4A, RAMP2, RAPGEF3, SOX18, TFAP2A, TIMP4, UCP1
○ (+) STAT6, TFE3, APPL2, APOL6, PXMP2, CAVIN1, MMP2, COL6A2, MT2A, TIMP1, METRN, METRNL, MYO1C, NQO1, SYAP1, CRNDE, TSPO, LRP1, HOXC9 (PanglaoDB)
② 종류 2. preadipocyte
③ 종류 3. chondrocyte
○ (+) Sox9, Col2a1
○ 3-1. columnar chondrocyte
○ (+) Sulf1, Robo1
○ 3-2. early hypertrophic chondrocyte
○ (+) Runx2, Ibsp
○ 3-3. late hypertrophic chondrocyte
○ (+) Spp1, Mmp9
○ 3-4. nucleus pulposus cells
○ (+) Pax1, Fmod
○ 3-5. prehypertrophic chondrocyte
○ (+) Prrx1, Fbxl7
○ 3-6. round chondrocyte
○ (+) Sox5, Sox9
④ 종류 4. fat cell
○ (+) GABRA4, SCD, CIDEA, PNLIPRP3, AWAT2, ACSBG1, KRT79, LCN1, GLDC, FAR2 (Tabula Sapiens)
⑤ 종류 5. fibroblast
○ (+) DCN, PRELP, RGS5, ACTA2 (α-SMA), PDGFRB (PDGFRβ), CD29, FAP, FSP1, CAV1(caveolin 1), Apod, Apoe, IGF1, MMP1, MMP12, PIM1, TAC1, TCEAL7
○ (+) CD248, SFRP2, COL1A1, GAS1, CCDC80, PCOLCE2, ISLR, COL5A1, PLA2G2A, FBN1 (Tabula Sapiens)
○ (+) DCN, APOD, CFD, MGP, GSN, APOE, FBLN1, LGALS1, MMP2, LUM (Tabula Microcebus)
○ (+) LUM, COL6A2, MMP2, IGFBP6, CDH11, COL6A3, C1S, RARRES2, SPON2, CTGF, COL1A2, COL3A1, VIM, FSTL1, GSN, SPARC, S100A4, COL1A1, MGP, SERPINH1, DCN, EGR1, FOSB, KLF6, STAT3, CXCL14 (PanglaoDB)
○ (+) AMOTL2, DPT, ISLR, SVEP1, FGF7, ELN, TCF21, ASPN, COL14A1, PRDX4, S1PR2, C7, COL6A3, MMP2, VIM (SCEVAN)
○ 5-1. activated fibroblast
○ (+) COL1A1, COL1A2, COL3A1, COL22A1, FAP, NOX4, POSTN, THBS4, NNMT, COL5A1, SPP1, FN1, CTHRC
○ 5-2. alveolar fibroblast
○ (+) MGP, APOD, APOE, DCN, JUN, CTGF, FOS, MFAP4, SELENOP, JUNB (Tabula Microcebus)
○ 5-3. cancer-associated fibroblast (CAF)
○ (+) FAP, THY1, FST1, BGN, DCN, COL1A1, COL1A2, COL3A1, COL5A1, COL6A1, COL6A2, COL6A3, CD90.2, FSP-1
○ (-) CD45
○ 5-3-1. CAF-S1 (immunosuppressive function)
○ 5-3-1-1. myCAF (myofibroblastic)
○ (+) HSD17B2, TCF21, FOXF1, NR2F1, PDPN, PLAT, EMILIN1, PDGFRA, APCDD1, CYGB (Tabula Sapiens)
○ (+) APOD, APOE, MGP, COL1A2, LGALS1, DCN, COL1A1, TAGLN, FBLN1, CFD (Tabula Microcebus)
○ 종류 1. ecm-myCAF
○ (+) LRRC15, GBJ2
○ 종류 2. TGFβ-myCAF
○ 종류 3. wound-myCAF
○ 종류 4. IFNαβ-myCAF
○ 종류 5. acto-myCAF
○ 5-3-1-2. iCAF (inflammatory)
○ 종류 1. detox-iCAF
○ (+) ADH1B, GPX3
○ 종류 2. IL-iCAF
○ 종류 3. IFNγ-iCAF
○ 5-3-2. CAF-S2
○ 5-3-3. CAF-S3 (abundant in healthy tissue)
○ 5-3-4. CAF-S4 (pro-metastatic function)
○ 5-3-5. CAFap (antigen-presenting CAF)
○ (+) ACTA2, HLA-DRA, CD74
○ 5-4. fibroblast of breast
○ (+) ARSG, THBS2, JHDM1D-AS1, CLMP, RSPO3, TWIST1, MMP3, LOX, FRMD4A, SLC7A2 (Tabula Sapiens)
○ 5-5. fibroblast of cardiac tissue
○ (+) CDH19, CRLF1, FMOD, FAIM2, ADAMTSL2, ABCA6, PRELP, MATN2, PLEKHH2, FIBIN (Tabula Sapiens)
○ 5-6. myofibroblast
○ (+) ACTA2, CDH11, CTHRC1
⑥ 종류 6. goblet cell
○ (+) TFF3, FCGBP, STARD10, TSPAN1, CKB, MUC4, GOLM1, TMC5, PIGR, SLC26A2 (Tabula Sapiens)
⑦ 종류 7. limbal stromal cell
⑧ 종류 8. melanocyte
○ (+) MIA, TYR, SLC45A2, CDH19, PMEL
○ (+) TYR, MITF, TRPM1, MLANA, TYRP1, DCT, BCAN, PMEL, CHCHD6, GPR143 (Tabula Sapiens)
⑶ 조직 2. muscle
① (+) CMSS1, MT1A, AXL, SLC7A2, PHLDB2, ADAMTS4, KCNE4, VASN, TWIST1, MTHFD2 (Tabula Sapiens)
② 종류 1. bronchial smooth muscle cell
○ (+) ENAH, PDLIM7, NTRK3, RASL12, DES, AOC3, GUCY1B3, C2orf40, CASQ2, ACTG2 (Tabula Sapiens)
③ 종류 2. cardiac muscle cell (cardiomyocyte, 심근세포)
○ (+) MYH6, TECRL, COL2A1, AC020909.2, NKX2-5, FBN2, TNNT2, MYL4, MYL7, ACTC1 (Tabula Sapiens)
④ 종류 3. skeletal muscle cell
○ (+) RP11-755O11.2, ASB15, RP11-456H18.2, RPL7P3, PVALB, RN7SL365P, RP11-432J24.5, C8orf22, ASB10, RP5-921G16.2, CLDN9, RP5-1039K5.13, AC137723.5, RP11-255G21.1, AC093063.2 (sc-type)
○ 3-1. myoblast
○ 3-2. myocyte
○ 3-3. satellite cell
○ (+) Sds, Myod1, Chrdl2, Asb5, Fam132b, Popdc3, Chodl, Ank1, Gdnf, Des (Tabula Muris)
⑤ 종류 4. fast muscle cell
○ (+) MYH2, MYL1, KLHL40, TNNC2, TNNI2, MYLPF, RPL3L, ATP2A1, FHL3, MYBPC2 (Tabula Sapiens)
⑥ 종류 5. slow muscle cell
○ (+) MYL1, RP11-451G4.2, RPL3L, MYL6B, MYL2, ANKRD2, MYOZ1, TNNC2, CKM, NRAP (Tabula Sapiens)
⑦ 종류 6. smooth muscle cell
○ (+) AKR1C1, AVPR1A, CCL8, CRISPLD2, CTH, FOXC2, FSTL3, LARS, MYH11, PDGFRB, PDK4, SSTR2, THAP2
○ (+) OR51E2, AC131025.8, ADORA2B, MYH11, SLC38A11, MIR143HG, MIR145, RP11-1101K5.1, P2RX3, GPR176, ANO1, OR51E1, CORIN, CACNA1C-IT3, TMC4 (sc-type)
○ (+) MYH10, ITGA8, NOV, SUSD5, SORBS1, MYH11, BGN, CNN1, SMTN, LTBP1 (Tabula Sapiens)
○ (+) ACTA2, CNN1, NOTCH3, MYH11, ACTG2, SOD3, LMOD1, MSRB3, BGN, MYL9, MYLK, SNCG, PLN (PanglaoDB)
○ 6-1. airway smooth muscle cell
○ 6-2. myoepithelial cell
○ (+) CNN1, MYH11, ACTG2, MYLK, MYL9 (PanglaoDB)
○ 6-3. myofibroblast
○ 6-4. pulmonary vascular smooth muscle cell
○ 6-5. vascular smooth muscle cell
○ (+) S100A6, ADIRF, TAGLN, TPM2, ACTA2, MUSTN1, CRIP1, C5H11orf96, TPM1, DSTN (Tabula Microcebus)
⑧ 종류 7. tendon cell
○ (+) FMOD, THBS4, TNMD, MYOC, XG, ITGA10, FIBIN, CDO1, GEM, CILP (Tabula Sapiens)
⑨ 종류 8. tongue muscle cell
○ (+) PHACTR3, PAX7, TLN2, CHRNA1, KLHL41, MAP1A, MUSK, H19, HTRA3, NPTX2 (Tabula Sapiens)
⑩ 종류 9. vascular associated smooth muscle cell
○ (+) RERGL, FHL5, ACTA2, CNN1, MRGPRF, MYLK, ACTG2, TBX2, AOC3, PTP4A3 (Tabula Sapiens)
⑪ 종류 10. megakaryocyte
○ (+) PF4, ITGA2B, LIPH, ELOVL7, GP6, ITGB3, PTGS1, RP11-480G7.1, RP11-170N16.2, C3orf55, RP4-655J12.4, TUBB1, DCLRE1A, TMEM40, GNAZ (sc-type)
⑫ 종류 11. Schwann cell
○ (+) UGT8, POU3F1, PMP2, GFRA3, KCNC2, MPZ, SOX10, PTPRZ1, COL20A1, LINC01037, BCAN, C2orf72, C10orf82, RP11-946L20.2, MAG (sc-type)
⑬ 종류 12. stromal cell
○ (+) WSCD2, C13orf45, LINC00645, RP1-300G12.2, RP11-217C7.1, RP11-332E3.2, RP11-473E2.4, CTD-2555C10.3, RP11-342A23.1, WNT10B, ACKR4, DIO3, CCDC129, ZCCHC5, RP11-38H17.1 (sc-type)
⑭ 종류 13. satellite cell
○ (+) AC004014.3, MYEOV, TACR3, GDPD4, USP44, RGR, RP11-320P7.2, FAM132B, GPR123, CTB-175P5.4, ENPP7P10, CHRDL2, PAX7, RP11-706J10.1, MAPK15 (sc-type)
⑮ 종류 14. myometrial cell
○ (+) C16orf45, ACTG2, FHL5, KCNMB1, DES, CNN1, RRAD, HILPDA, LMCD1, PPP1R14A (Tabula Sapiens)
⑷ 조직 3. stem cell
① (+) DMRTA2, FGFR3, RASSF6, COL17A1, PAX6, CHL1, TNS4, KRT12, COL7A1, SYT8 (Tabula Sapiens)
② 종류 1. brain neural stem cell
○ (+) SOX2, PROM1, NES, SOX9 (sc-type)
③ 종류 2. cancer stem cell
○ 2-1. kidney cancer stem cell
○ (+) EPCAM
○ 2-2. pancreas cancer stem cell
○ (+) CD24, CD44, FLOT2
○ 2-3. liver cancer stem cell
○ (+) ANPEP, CD44, EPCAM, POU5F1, PROM1, THY1
○ 2-4. lung cancer stem cell
○ (+) ABCG2, ALCAM, ALDH1A1, BMI1, CD24, CD44, KIT, NANOG, NES, PDPN, POU5F1, PROM1, SOX2, THY1
○ 2-5. brain cancer stem cell
○ (+) FUT4, MSI1, NES, PROM1, SOX2, THY1
④ 종류 3. immune system stem cell
○ 3-1. pancreas immune system stem cell
○ (+) MS4A1, CD19, CD4, CD8A, CD7, CTLA4, CD27, CCR7, CYTIP, IGHD, CD38, IL2RA, ISG20, SELL, IL7R, FOXP3, IGKC, IGLC3, IGLC2, CD79A, CD68, CD163, CD14, ITGAM, MRC1, MS4A7, CD3D, CD3E, CD3G (sc-type)
○ 3-2. liver immune stem cell
○ (+) CD19, MS4A1, IL2RA, PTPRC, CD4, CD8A, CD3D, CD3E, CD3G, CD11c, CD14, CD16, CD56, CD16, CD42b, CD7, CD8, IgD, CD38, CD24, CD20, CD14, CD16, HLA-DR, CD11b, CD11c, CD123, CD15, CD33, CD66b, CD27, CD94, CD45 (sc-type)
○ 3-3. brain immune stem cell
○ (+) MS4A1, CCR6, CXCR3, CD4, IL2RA, ISG20, TNFRSF8, Trac, Ltb, Cd52 (sc-type)
○ 3-4. lung immune stem cell
○ (+) ADGRE1, ARG1, BIRC5, CCL17, CCL18, CD14, CD163, CD19, CD22, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD68, CD74, CD80, CD83, CD86, CD8A, CD8B, CDCA3, CDK1, CEBPE, CR2, CSF1R, EAF2, FCER2, FCGR3A, FLT3, GIMAP3P, HLA-DRA, HMMR, IGHM, IL2RA, ITGAE, ITGAM, ITGAX, LAX1, MS4A14, MZB1, NRP1, NUSAP1, PAX5, PRG2, PTPRC, SLPI, THBD, TNFRSF17, TRBC1, XCR1 (sc-type)
⑤ 종류 4. mesenchymal stem cell
○ 4-1. liver mesenchymal stem cell
○ (+) CD44, ENG, NT5E, ITGB1, THY1 (sc-type)
⑥ 종류 5. skeletal muscle satellite stem cell
○ (+) MYF5, DLK1, KLHL41, PPM1L, CADM2, GPM6B, PON2, SGCA, WEE1, TPD52L1
⑦ 종류 6. limbal stem cell
⑧ 종류 7. epidermal stem cell
○ (+) ITGA6, ITGB1
⑸ 조직 4. bone stroma
① 종류 1. osteoblast
○ (+) BGLAP, COL1A1, IBSP, Bglap, Alpl
② 종류 2. osteoclast
○ (+) TRAP, calcitonin receptor (CTR), cathepsin K, NFATC1, SMAD2/3, RXR
③ 종류 3. osteocyte
④ 종류 4. osteoclast precursor cell
⑹ 조직 5. hepatic stroma (liver stroma)
① 종류 1. hematopoietic cell
○ (+) CD34, PTPRC
② 종류 2. 간 성상세포(hepatic stellate cell, HSC) : liver fibrogenesis 개시 및 발달에 필수적. 내피세포 및 간 외피세포와 상호작용
○ (+) Desmin
○ (+) CYGB, PPARG, PDGFRA, RGS5, PPARA, FOXF1, ALB, NR1H4, CCN2, SEMA7A, WT1, FGF10, GFAP, NGFR, VEGFA, ACTA2, MYB, DES, FAP, SLC8A1, RELN, SYP, VCL, TIMP1, COL1A1, TAGLN, COL1A2, COL3A1, SPARC, RBP1, DCN, MYL9, TPM2, MEG3, BGN, IGFBP7, IGFBP3, CCN1, OLFML3, IGFBP6, CCL2, COLEC11, HGF (sc-type)
○ (+) PPARG, ALB, CTGF, ACTA2, VCL, TIMP1, COL1A1, COL1A2, COL3A1, SPARC, RBP1, DCN, MYL9, TPM2, MEG3, BGN, IGFBP7, IGFBP3, CYR61, OLFML3, IGFBP6, CCL2, COLEC11 (PanglaoDB)
③ 종류 3. hepatoblast
○ (+) AFP, ALB, CEBPA, KRT14, DLK1, CDH1, FOXM1, GGT1, HNF4A, PROX1, MAP2K4, SMAD5, KRT18, KRT8, HNF1B, HHEX, MET (sc-type)
④ 종류 4. hepatocyte : 간의 구성에서 60-80 %를 차지함
○ (+) ALB, Apoc4, Uox, Tat, Slc25a47
○ (+) AFP, HNF4A, KRT8, ALB, KRT18, FOSL1, EPPK1, UCP2, GCK, LRP5, SLC10A1, NOS2, ATP7B, GJB2, FGFR4, PROX1, CRP, SLC2A2, TFR2, KIF13B, LIPC, VDR, ASGR1, ARG1, G6PC, OTC, SERPINA1, ZHX2, HHEX, FOXA3, FOXA2, FOXA1, CYP2E1, CYP1A2, CEBPA, CDH1, GPC3, AHR, CPS1, GLS2, PCK1, TAT, WT1, PRRG4, SULT1A1, APOH, CTNNB1, ABCC3, FGB, AQP3, PLSCR1, FGA, APOB, ANG, ANXA13, SAT2, SFRP5, A1CF, APOA1, BNIP3, FGL1, PAH, SERPINA6, APOA2, AZGP1, FGG, APOC3, DEFB1, TM4SF4, GC, AMBP, ORM1, TTR, HAL, ASS1, SCD, HMGCS1, ACSS2, TM7SF2, SEC16B, SLBP, RND3, BCHE, GHR, ALDH6A1, MASP2, AKR1C1, HAMP, GLUL, ACLY, ASL, TMEM97, CP, SLPI, ACAT2, TM4SF5, MSMO1, LEPR, RCAN1, AR, RPP25L, HSD11B1, APOM, TKFC, G0S2, PON3, C1orf53, TTC36, FST, MCC, AQP9, GSTA2, NNT, SAA4, MRPS18C, OCIAD1, APOA5, ENTPD5, C4B, EID2, TP53INP2, ATIC, SERPINH1, SAMD5, GRB14, CD3G, RHOB, EPB41L4B, GPAT4, SPTBN1, SDC2, PHLDA1, WTAP, ACADM (sc-type)
○ (+) MAT1A, AGXT, KNG1, TAT, CRP, ITIH1, HPX, APOA2, CYP2E1, CPS1 (Tabula Sapiens)
○ (+) ALB, SERPINA1, APOH, FGB, FGA, APOA1, FGL1, APOA2, FGG, APOC3, AMBP, ORM1, TTR (PanglaoDB)
○ 4-1. periportal hepatoycyte
○ (+) SDS (gulconeogenesis), Alb, Cyp2f2, Sds (gulconeogenesis)
○ 4-2. pericentral hepatocyte (centrilobular hepatocyte)
○ (+) GLUL, CYP2E1, Cyp2e1, Gsta3
○ 응용. pericentral → periportal gradient (ref)
○ Glul, Oat, Cyp2a5, Mup9, Mup17, Cyp2c29, Cyp2e1, Mup11, Hamp, Ass1, Serpina1e, Cyp2f2, Alb, Mup20
⑺ 조직 6. eye stroma
① 종류 1. 양극세포(bipolar cell)
○ (+) NRSN1, SLC24A2, VSX2, CELF3, STMN4, MDGA2, TMEM179, TMEM196, GNG13, GNG3 (Tabula Sapiens)
○ 1-1. rod bipolar cell
○ (+) PRKCA, PCP4, RCVRN, SLC1A2, Car8, Sebox, Vsx2, Otx2, GRM3, KCNA4, KCNMA1, RORB, Cabp5, Og9x, Vstm2b, Casp7, Rpa1, GABRA1, LHX4 (sc-type)
○ 1-2. cone bipolar cell
○ (+) PCP4, RCVRN, SLC1A2, Car8, Scgn, Vsx2, Otx2, MIP, GNAS, ISL1, SLC1A7, GJD2, GNB3, GRIA4, TJP2, LRIT2, Cabp5, Scgn, Vsx1, GABRA1, LHX4, LHX3 (sc-type)
② 종류 2. muller cell
○ (+) Apoe, Glul, Rlbp1, Abca8a, Vim, Aldh1a1, RLBP1, GLUL, PAX6, CA8, EDN2, KCNJ2, PRSS56, RGR, ApoE, Aqp4 (sc-type)
○ (+) RLBP1, RAX, FABP7, GFAP, CRABP1, MT-TV, LINC00461, DEFB119, RGR, LINC00632 (Tabula Sapiens)
③ 종류 3. astrocyte
○ (+) PRDX6, SLC1a3, PAX2, Rlbp1, GFAP, S100B (sc-type)
④ 종류 4. retinal ganglion cell
○ (+) BMP4, GRIA4, GRM3, KCNJ2, MED1, NMT, POU6F2, ZIC2, SLC17a6, Pax6, THY1, Nefl, Pou4f2, SNCG, NRN1, Cerkl (sc-type)
○ (+) NHLH2, SMIM18, CCDC184, NKAIN3, SRRM3, NARF, CPNE4, CACNB3, SLC17A6, DNER, FXYD7, NEFM, SNCG (PanglaoDB)
⑤ 종류 5. retinal progenitor cell
○ (+) PAX6, CALB2, SIX6, RHO, SIX3, NEFH, LGR5, SAG, RAX, NOTCH1, HES1, MSI1, SOX9, KIT, PDGFRA, Og9x, Sfrp2, Fgf15 (sc-type)
⑥ 종류 6. GABAergic amacrine cell
○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln (sc-type)
⑦ 종류 7. 수평세포(horizontal cell)
○ (+) Rcvrn, Prox1, Ntrk1, Lhx1, Lim2, Calb2, CALB1, LIM1, DLG2, TFAP2B, ZEB2, Lim1 (sc-type)
⑧ 종류 8. 시냅스(synapse)
○ (+) SYP, DLG4, HOMER1, SLC32A1 (sc-type)
⑨ 종류 9. 섬유아세포(fibroblast)
○ (+) PAX6, COL1A1, TGFB1, ACTA2, ICAM1, FBLN1, CRHBP, FN1, PDGFRA (sc-type)
⑩ 종류 10. pericyte
○ (+) Kcnj8, Rgs5, Dlk1, Abcc9, SUR2B, DLK1, VCAM1 (sc-type)
⑪ 종류 11. exctracellular matrix cell
○ (+) ANTXR2, COL10A1, EFEMP1, LAMA2, SNTB1, TCF7L2, TGFBR1, TMEM98, VIPR2, ZIC2 (sc-type)
⑫ 종류 12. glycinergic amacrine cell
○ (+) Pax6, Tfap2a, Fut4, Calb2, Pvalb, Slc6a9, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, GlyT1, TgfB2, BE996002, Camkv, TCF4, Efna5, Dab1, Slc6a9 (sc-type)
⑬ 종류 13. cholinergic GABAergic amacrine cell
○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln, VAChT, Tac1, Scube2, Cpne4, Sox2, Slit, SCGN (sc-type)
⑭ 종류 14. Tachykinin GABAergic amacrine cell
○ (+) Pax6, Tfap2a, Gad2, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ISL1, Gad1, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, Nr4a2, Ngn2, C1ql2, Reln, ZPF58, Cdh4, Grik4, Grm8, Slit2, SCGN (sc-type)
⑮ 종류 15. starbust amacrine cell
○ (+) Pax6, Tfap2a, Fut4, Calb2, Pvalb, Pcp4, Vip, Thy1, STX1A, MIP, GNAS, ZEB2, TJP2, SEMA3D, POU6F2, KCNMA1, KCNA4, GRM3, GJD2, FRMPD2, Prox1, GAD1, CHAT, SLC5A7 (sc-type)
⑯ 종류 16. adipocyte
⑰ 종류 17. ciliary body
⑱ 종류 18. beam cell (A/B/X/Y) : fibroblast-like (ref)
⑲ 종류 19. JCT(juxtacanalicular tissue) cell
⑻ 조직 7. pancreatic stroma
① 종류 1. pancreatic acinar cell
○ (+) CTRB1, KLK1, RBPJL, PTF1A, CELA3A, PRSS1, SPINK1, ZG16, CEL, CELA2A, CPB1, CELA1, RNASE1, AMY2B, CPA2, CPA1, CELA3B, PNLIP, CTRB2, PLA2G1B, PRSS2, CLPS, REG1A, SYCN, PNLIPRP1, CTRC, REG3A, PRSS3, REG1B, CFB, GDF15, MUC1, C15orf48, AKR1C3, OLFM4, GSTA1, LGALS2, PDZK1IP1, RARRES2, CXCL17, GSTA2, ANPEP, LYZ, ANGPTL4, ALDOB (sc-type)
○ (+) AMY2A, CELA3B, CELA3A, CELA2A, CTRB2, CPA2, PRSS3P2, PNLIPRP1, CTRL, PNLIPRP2 (Tabula Sapiens)
○ (+) PRSS2, CPA1, CTRC, LOC105875474, LOC105873340, CTRB1, LOC105873633, CLPS, PLA2G1B, LOC105873613 (Tabula Microcebus)
○ (+) CTRB1, KLK1, CELA3A, PRSS1, SPINK1, CPB1, RNASE1, CPA2, CPA1, CELA3B, PNLIP, CTRB2, PLA2G1B, PRSS2, CLPS, REG1A, SYCN, PNLIPRP1, CTRC, REG3A, PRSS3, REG1B, GDF15, MUC1, C15ORF48, AKR1C3, OLFM4, GSTA1, LGALS2, PDZK1IP1, RARRES2, CXCL17, GSTA2, ANPEP, ALDOB (PanglaoDB)
② 종류 2. pancreatic alpha cell
○ (+) GCG, TTR, ARX, POU3F4, NKX2-2, RESP18, PYY, PCSK2, SLC38A5, TM4SF4, CRYBA2, NKX6-1, KCNK16, PCSK1, PRRG2, IRX2, ALDH1A1, PEMT, CHGA, SMIM24, F10, SCGN, SLC30A8, SH3GL2, SCGB2A1, FAP, DPP4, MAFB, PAX6, NEUROD1, PLCE1, GC, KLHL41, FEV, PTGER3, RFX6, SMARCA1, PGR, LDB2, IRX1, UCP2 (sc-type)
○ (+) GCG, TTR, PCSK2, TM4SF4, CRYBA2, ALDH1A1, PEMT, CHGA, SMIM24, F10, SCGN, SLC30A8, SCGB2A1, MAFB, NEUROD1, GC, FXYD5 (PanglaoDB)
③ 종류 3. pancreatic beta cell
○ (+) FXYD2, PDX1, INS, GCGR, JPH3, CD40, HAMP, EZH1, NTRK1, SLC2A2, NKX6-2, NPY, RIMS1, MAFA, EFNA5, LMX1A, NKX2-2, NKX6-1, PAX4, IAPP, PCSK2, G6PC2, SLC30A8, PCSK1, GJD2, SCGN, IGF2, SYT13, FFAR2, NPTX2, PFKFB2, EDARADD, HOPX, SH3GL2, ADCYAP1, SCGB2A1, CASR, MAFB, PAX6, NEUROD1, ISL1, TGFBR3, SMAD9, SIX3, SIX2, BMP5, PIR (sc-type)
○ (+) PDX1, INS, MAFA, NKX2-2, NKX6-1, IAPP, PCSK2, G6PC2, SLC30A8, PCSK1, GJD2, SCGN, SYT13, NPTX2, HOPX, ADCYAP1, SCGB2A1, MAFB, PAX6, NEUROD1, ISL1, DLK1, MEG3 (PanglaoDB)
④ 종류 4. pancreatic delta cell
○ (+) SST, PDX1, FFAR4, PCSK9, RBP4, PAX4, RESP18, HHEX, ISL1, SCGN, KCNK16, IAPP, FXYD2, NPTX2, GPC5-AS1, UCP2, LEPR, BAIAP3, MS4A8, CASR, BCHE, GABRB3, UNC5B, EDN3, PRG4, FRZB, PCSK1, GABRG2, POU3F1, BHLHE41, EHF, LCORL, ETV1 (sc-type)
○ (+) SST, RBP4, HHEX, ISL1, SCGN, IAPP, GPC5-AS1, PCSK1 (PanglaoDB)
⑤ 종류 5. pancreatic epsilon cell
○ (+) GHRL, ANXA13, PHGR1, BMP4, HMGCS2, TM4SF5, OLFML3, ASGR1, COX6A2, NPY1R, SLC7A9, BHMT, OPRK1, PTGER4, ITGA4, EYA4, XYLB, ELOVL2, AFF3, CORIN, MYO1A, HRH2, SLC6A16, PCSK6, ADAMTS6, COL22A1, FAM124A, COL12A1, CD109, THSD4, ARX (sc-type)
⑥ 종류 6. pancreatic gamma (PP) cell
○ (+) PPY, SCGN, FXYD2, SCGB2A1, GPC5-AS1, CMTM8, ARX, ETV1, PXK, SERTM1, SLITRK6, SEMA3E, APOBEC2, ABCC9, NEUROD1, PAX6, ISL1, CARTPT, THSD7A, AQP3, ENTPD2, PTGFR, CHN2, EGR3, LMO3, MEIS1, ZNF503 (sc-type)
○ (+) PPY, SCGN, SCGB2A1, GPC5-AS1, CMTM8, NEUROD1, AQP3 (PanglaoDB)
⑦ 종류 7. langerhans cell
○ (+) CD1A, Langerin (CD207), EpCAM, CD11c, RUNX3, ID2, AHR
○ (+) CD207, CCL22, DAPP1, C15orf48, TRAF1, NEDD4, HLA-DQA2, GNA15, GPR157, HLA-DQB2 (Tabula Sapiens)
○ (+) HLA-DMA, HLA-DMB, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1 (PanglaoDB)
⑧ 종류 8. pancreatic A cell
○ (+) GCG, KCNK16, CRH, SLC30A8, CPLX2, NKX2-2, CRYBA2, CHGA, INSM1, RFX6 (Tabula Sapiens)
⑨ 종류 9. pancreatic D cell
○ (+) KCNK16, GCG, SST, CRH, AVPR1B, GAD2, GPC5-AS1, ACTL6B, CPLX2, RP5-984P4.6 (Tabula Sapiens)
⑩ 종류 10. pancreatic PP cell
○ (+) PPY, GPC5-AS1, GAD2, PAM, NKX2-2, CALB1, SLC30A8, ARX, SCG2, STMN2 (Tabula Sapiens)
⑪ 종류 11. type B pancreatic cell
○ (+) KCNK16, GAD2, G6PC2, IAPP, FAM159B, RP5-984P4.6, MIR7-3HG, NKX2-2, SLC30A8, CELF3 (Tabula Sapiens)
⑼ 조직 8. intestine stroma
① 종류 1. enterocyte
○ (+) KRT20, PPARG, FABP1, ANPEP, CA1, FABP2, VIL1, CDH17, CDC42EP5, HNF4A, TMEM45B, ELF3, TMC4, PPP1R14D, CEACAM1, KLF5, CDX1, CDX2, PRR15L, MUC13, PHGR1, LGALS2, CD55, SLC26A2, SLC26A3, SLC51B, ABCG2, ACSL5, AQP8, SLC39A5, MAOA, DGAT1 (PanglaoDB)
○ 1-1. immature enterocyte
○ 1-2. mature enterocyte
○ (+) UGT2B17, LGALS4, FABP2, CHP2, CDX2, PPP1R14D, FABP1, CDH17, TSPAN8, CES2 (Tabula Sapiens)
○ 1-3. proximal enterocyte
② 종류 2. crypt cell
○ 2-1. intestinal crypt stem cell
○ (+) TSPAN8, UGT2B17, SLC12A2, URAD, LEFTY1, ADH1C, RGMB, CDX2, LGALS4, CHP2 (Tabula Sapiens)
○ 2-2. intestinal crypt stem cell of large intestine
○ (+) RN7SK, RNU6ATAC, MAFA, HSPA2, HIST4H4, CSRNP2, HIST1H2AG, PARD6G-AS1, DLL4, MTMR11 (Tabula Sapiens)
○ 2-3. intestinal crypt stem cell of small intestine
○ (+) APOBEC1, CCL25, RBP2, CLDN15, MISP, SLC39A4, PRAP1, ARL14, RHPN2, AC021218.2 (Tabula Sapiens)
③ 종류 3. goblet cell
○ (+) MUC2, ITLN1, TFF3, AGR2, PHGR1, MUC13, FCGBP, ZG16, KLK1, SPINK4 (PanglaoDB)
○ 3-1. large intestine goblet cell
○ (+) MUC2, BEST2, CLCA1, ZG16, TFF3, ST6GALNAC1, REP15, FCGBP, HEPACAM2, WNK4 (Tabula Sapiens)
○ 3-2. small intestine goblet cell
○ (+) CLCA1, MUC2, ZG16, SPINK4, FER1L6, TFF3, ITLN1, SCNN1A, REG4, GALNT8 (Tabula Sapiens)
④ 종류 4. transit amplifying cell
○ 4-1. transit amplifying cell of large intestine
○ 4-2. transit amplifying cell of small intestine
○ (+) CCL25, RBP2, FABP2, MUC17, SLC5A1, CLDN15, PRAP1, OLFM4, CHP2, VIL1 (Tabula Sapiens)
○ 4-3. transit amplifying cell of colon
○ (+) NOX1, URAD, LEFTY1, UGT2B17, LGALS4, CDX1, CDX2, NXPE4, TSPAN8, PPP1R14D (Tabula Sapiens)
⑤ 종류 5. intestinal enteroendocrine cell
○ (+) NKX2-2, INSM1, MIR7-3HG, FEV, CHGA, RFX6, CRYBA2, RIMBP2, PCSK1N, SCG3 (Tabula Sapiens)
○ (+) SCGN, SST, GCG, CHGB, CPE, IAPP, CHGA (PanglaoDB)
⑥ 종류 6. intestinal tuft cell
○ (+) GNAT3, SH2D7, GNG13, CCDC129, TRPM5, LRMP, SH2D6, MATK, CCSER1, POU2F3 (Tabula Sapiens)
⑦ 종류 7. enteric glia cell
○ (+) GFRA3, MPZ, LGI4, RGS16, ALDH1A1, L1CAM, DKK3, INTS6, DHRS3, S100B (PanglaoDB)
⑧ 종류 8. enteric neuron
⑨ 종류 9. enterochromaffin cell
⑩ 종류 10. foveolar cell
⑪ 종류 11. gastric chief cell
⑫ 종류 12. microfold cell
⑬ 종류 13. paneth cell
⑭ 종류 14. parietal cell
⑽ 조직 9. kidney stroma
① 종류 1. podocyte
○ (+) NPHS1, NPHS2, EZR, TDRD5, SEMA3G, SEMA5A, SEMA3E, PLA2R1, COL4A4, ARHGAP24, WT1, COL4A3, RHPN1, MAFB, PODXL, CLIC5, CD2AP, NOTCH2 (sc-type)
○ (+) PODXL, VEGFA, SYNPO, NPHS1, NPHS2, WT1, PTPRO, THSD7A, MAFB, ENPEP, CLIC5, BCAM, MAGI2, EFNB1, PLOD2, SRGAP1, TCF21, PTH1R, CTGF, TRIB2, DACH1, AIF1L, GOLIM4, TOB1 (PanglaoDB)
② 종류 2. cancer stem cell
○ (+) EPCAM
③ 종류 3. mesangial cell (신사구체간질 세포)
○ (+) PDGFRB, PDGFB, LAMA4, ITGA8, LGALS1, ARID5B, CCR7, FN1, GATA3, PAWR, SERPINE2, TBX18, TEK, THY1, REN, ZEB2 (sc-type)
○ (+) PDGFRB, ANGPT2, CTGF, GATA3, ITGA8, ARID5B, FN1, PTN, MYL9, TPM2, CALD1, HOPX, ACTN1, AKAP12, ROCK1, SH3BGRL, FILIP1L, FLNA, MEF2C, CSTB, MAP3K20 (PanglaoDB)
④ 종류 4. cap mesenchyme cell (mesenchymal cell)
○ (+) SIX2, ITGA8, NR2F2, EYA1, MEIS2, CITED1, MUC1, NOTCH2 (sc-type)
⑤ 종류 5. stromal cell
○ (+) MEIS1, TCF21, COL1A2, COL3A1, TNC, COL6A3, LGALS1 (sc-type)
⑥ 종류 6. juxtaglomerular cell
○ (+) REN, CRIP1 (sc-type)
⑦ 종류 7. renal interstitium (mesenchymal cell)
○ (+) SFRP1, MEIS1, PDGFRA, C7, MGP (sc-type)
⑧ 종류 8. cancer stem cell
○ (+) EPCAM (sc-type)
⑨ 종류 9. kidney progenitor cell
○ (+) PAX2, EYA1, WT1, CITED1 (PanglaoDB)
⑩ 종류 10. principal cell
⑪ 종류 11. transient cell
⑾ 조직 10. brain stroma
① 종류 1. 뉴런(neuron)
○ (+) ENO2, NEFM, SLC12A5, TMEM130, CLSTN3, ARID4A, RHBDD2, TMEM59L, MIAT, AAK1, SPOCK3, DNM3, DNER, CHN1, GABBR2, MEG3, BEX2, BEX1, CAMK2N1, PNISR, STMN2, SNAP25, VSNL1, ATP6V0A1, MYO5A, DYNC1I1, ELAVL3 (PanglaoDB)
○ (+) CAMKV, EPHA3, NEUROD6, SLC24A2, NELL1, GAP43, SOX11, ELAVL4, BEX1, RTN1, SNAP25, SYT1, ELAVL3, STMN2, STMN4 (SCEVAN)
○ 1-1. cholinergic neuron
○ (+) Slc18a3
○ (+) CHAT, SLC18A3, ACHE (sc-type)
○ 1-2. dopaminergic neuron
○ (+) Slc6a3
○ (+) TH, SLC6A3, FOXA2, KCNJ6, NR4A2, LMX1B, DBH, SLC6A2, PPP1R1B (sc-type)
○ 1-3. GABAergic neuron
○ (+) Slc32a1
○ (+) SLC6A1, GABBR1, GABBR2, GAD2, GAD1, SLC32A1 (sc-type)
○ 1-4. glutamatergic neuron
○ (+) Slc17a7, Slc17a6, Slc17a8
○ (+) SLC17A7, SLC17A6, GRIN1, GRIN2B, GLS, GLUL, GRIN2A (sc-type)
○ 1-5. serotonergic neuron
○ (+) Slc6a4
○ (+) TPH1, SLC6A4, FEV, HTR1A, HTR1B (sc-type)
○ (+) TPH1, FEV, DDC (PanglaoDB)
○ 1-6. adrenergic neuron
○ 1-7. glycinergic neuron
○ (+) Slc6a5
○ 1-8. noradrenergic neuron
○ (+) Slc6a2
○ 1-9. histaminergic neuron
○ (+) Hdc
○ 1-10. bipolar neuron
○ 1-11. immature neuron
○ (+) DCX, NEUROD1, TBR1, STMN1, NCAM1, TUBB3 (sc-type)
○ 1-12. mature neuron
○ (+) RBFOX3, MAP2, SYP, DLG4, TUBB3, MAPT, INA, GAP43, NRP1 (sc-type)
○ (+) TUJ1
○ 1-13. neural progenitor cell
○ (+) CSPG4, RNF5, EOMES, SOX2, SOX1, NES, PAX3, PAX6, OTX2, CNTNAP1, ASCL1, SMARCA4, MSI1, MSI2 (sc-type)
○ 1-14. neural stem cell
○ (+) SOX2, PROM1, NES, SOX9 (sc-type)
○ 1-15. interneuron
○ 1-15-1. interneuron progenitor
○ (+) Dlx1, Dlx2, Lhx6, Nkx2-1
○ 1-16. peripheral nerve
○ (+) MPZ, S100B, LGI4, PLP1
○ 1-17. motor neuron
○ 1-18. noradrenergic neuron
○ 1-19. Purkinje neuron
○ (+) Pcp4, Car8, Calb1, Slc1a3, Ppp1r17, Pvalb
○ 1-20. pyramidal cell
○ 1-21. trigerminal neuron
○ 1-22. granule neuron
○ (+) Snap25, Cbln3, Gabra6
○ 상태 1. inhibitory neuron
○ (+) Lamp5, Sncg, Vip, Sst, Pvalb
② 종류 2. glial cell (신경교세포)
○ 2-1. glioblasts
○ (+) Aldh1l1, Efna5, Wnt1, Wnt9a, Rspo1/2/3
○ 2-2. neuroblasts
○ (+) Npas3, Adgrb3, Fgf15, Wnt7b, Tnc
○ (+) NEUROD1, DCX, DLX2, PROX1, EOMES, TUBB3 (sc-type)
○ 2-3. radial glial cell
○ (+) Mki67, Dbx1
○ (+) SOX15, RP11-54H7.4, FAM83A, LAMC2, BNC1, IRF6, ITGA2, DMRTA2, COL17A1, LAMA3 (Tabula Sapiens)
○ 2-4. Schwann cell
○ (+) UNC93B6, FOXD3, AC012470.1, DLX1, FOXD3-AS1, RP5-907C10.3, GDNF-AS1, SMIM41, PLP1, KLHDC8A
○ 2-4-1. myelinating Schwann cell
○ (+) SOX10, EGR2, MBP, MPZ (sc-type)
○ 2-4-2. non-myelinating Schwann cell
○ (+) SOX10, GAP43, NCAM1, NGFR (sc-type)
○ 2-4-3. Schwann precursor cell
○ (+) SOX10, GAP43, FABP7, MPZ, DHH, NGFR (sc-type)
○ 2-5. astrocyte
○ (+) Gfap, S100b
○ (+) GFAP, SLC1A3, SLC1A2, GLUL, S100B, ALDH1L1, AQP4, IGFBP3, ATP13A4, CBS, SOX9, CD40, CD80, CD86, C5AR1 (sc-type)
○ (+) S100B, SLC1A2, GFAP, SLC1A3, FGFR3, AQP4, AGT, GPR37L1, SLC6A11, SYNE1, PLXNB1, GJA1, APOE (PanglaoDB)
○ 2-6. oligodendrocyte (희소아교돌기세포)
○ (+) Mbp, Plp1, Mobp
○ (+) OLIG1, OLIG2, OLIG3, CLDN11, MBP, MOG, MAG, GALC, CNP, SOX10, FA2H, UGT8 (sc-type)
○ (+) MOG, TF, TMEM63A, PTGDS, MYRF, SEMA4D, GJB1, ERMN, CLDN11, ANLN, PLLP, PEX5L, ST18, MAG, ENPP2, PLP1, MBP (PanglaoDB)
○ (+) OLIG2, NKX2-2, SOX10, AACS, AARD, ABCA6, ABCA8, ABCB4, ABHD4, ABLIM2, ABTB2, AC023908.1, AC136616.1, ACAN, ACAP3 (SCEVAN)
○ 2-6-1. oligodendrocyte precursor cell
○ (+) LHFPL3, MEGF11, PCDH15, PDGFRA, CSPG4, RNF5 (sc-type)
○ (+) PDGFRA, GPR37L1, VCAN, EPN2, OLIG1, TNR, CNP (PanglaoDB)
○ 2-6-2. myelinating oligodendrocyte
○ (+) GALC, GPR17, MYRF, CNP, HES5, IL1RAP, NKX2-2, MBP, CLDN11, PLP1UGT8, MOG, SOX10, ERMN, MAG, MOBP (SCEVAN)
○ 2-7. radial glial cell
○ (+) VIM, NES, PAX6, HES1, HES5, GFAP, SLC1A3, FABP7, TNC, CDH2, SOX2 (sc-type)
○ 2-8. tanycyte
○ (+) GPR50, COL23A1 (sc-type)
○ 2-9. Bergmann glia
○ (+) Gfap
○ 2-10. Cajal-Retzius cell
○ 2-11. ganglion cell
○ 2-12. pinealocyte
○ 2-13. satellite glial cell
③ 종류 3. neuroendocrine cell
○ (+) Kcna1, Olfr558, Mpz, Casq2, Rgs5, Plp1, Pln, Sox10, Nrip2, Rgs4 (Tabula Muris)
⑿ 조직 11. lung stroma
① 종류 1. ciliated cell
○ (+) Dynlrb2, Foxj1
○ (+) APPL2, ATP5MD, CCDC153, CCDC17, CCDC181, CCDC39, CYP2S1, FAM161A, FOXJ1, LRRC23, ODF3B, SCGB1A1, SEC14L3, SNTN, STK11, TMEM212, TSPAN19, TUBB4B (sc-type)
○ (+) RP11-680N20.1, APOBEC4, RP11-60L3.6, RP11-122M14.1, EPPIN, DNAI1, AC009502.4, AC005281.1, LDLRAD1, SNTN (Tabula Sapiens)
○ (+) C20orf85, SNTN, ANKRD66, C11orf88, TMEM190, FAM216B, SRGAP3-AS2, STOML3, PIH1D3, C1orf194 (Tabula Sapiens)
○ 1-1. airway ciliated cell
② 종류 2. airway goblet cell
○ (+) AGR2, AQP5, CEACAM1, DMBT1, DUSP4, FXYD3, GALNT5, GALNT6, GGH, GOLPH3, GP2, IL19, LIPF, LTF, LYNX1, MSLN, MUC16, MUC4, MUC5B, NOS2, PIGR, QSOX1, SCGB3A1, SEC23B, SPDEF, TFF2 (sc-type)
③ 종류 3. hair follicle cells
○ (+) Krt5, Krt17
④ 종류 4. ionocyte (chloride cell) : mitochondrion-rich cell
○ (+) GPRC6A, ASCL3, FOXI1, BSND, FOXI2, LCNKB, TMPRSS11E, ATP6V0A4, TMEM61, ATP6V1C2 (Tabula Sapiens)
⑤ 종류 5. neuron
⑥ 종류 6. pulmonary ionocyte
○ (+) DMRT2
○ (+) CFTR, CLCNKB, FOXI1, KCNMA1, SCGB1A1, SLC12A2, TFCP2L1 (sc-type)
○ (+) CLDN25, ATP6V1G3, LINC00706, ASCL3, LINC01187, DDX4, CYP26A1, STAP1, SP9, BSND (Tabula Sapiens)
⑦ 종류 7. respiratory goblet cell
○ (+) SCGB1A1, BPIFB1, SCGB3A1, CYP2F1, VMO1, MUC5B, CXCL6, MSMB, CCNO, CYP2J2 (Tabula Sapiens)
⑧ 종류 8. respiratory mucous cell
⑨ 종류 9. pericyte
⑩ 종류 10. fibroblast
○ (+) COL3A1, COL5A2, DPT, FN1, GSN, LRP1, PDGFRA, TCF21 (sc-type)
○ 10-1. adventitial fibroblast : pericyte의 특수한 서브타입
○ 10-2. alveolar fibroblast
○ 10-3. intermediate pathological fibroblast
○ 10-4. mesothelial fibroblast
○ 10-5. pathological fibroblast
⑪ 종류 11. basal cell (airway progenitor cell)
○ (+) ABI3BP, AQP3, DAPL1, GSTM2, HPGD, ICAM1, KRT14, KRT15, KRT5, PHLDA3, RPS18, SDC1 (sc-type)
○ 11-1. airway basal cell
⑫ 종류 12. clara cell
○ (+) AHR, ALDH1A1, BPIFA1, CTSE, CYP2E1, CYP4B1, ERN1, FOXM1, LEPR, MUC1, MUC4, MUC5B, RAB3D, SCGB1A1, SCGB3A1, SCGB3A2, SFTPA1, SFTPC, SFTPD, SYT2 (sc-type)
○ (+) SCGB1A1, SCGB3A2, SFTPC, MUC1, CYP4B1, SCGB3A1, SFTPA1 (PanglaoDB)
⑬ 종류 13. secretory cell
○ (+) MUC5B, PIGR, SCGB1A1 (sc-type)
⑭ 종류 14. airway mucous cell
⑮ 종류 15. airway smooth muscle
○ 15-1. airway smooth muscle
○ 15-2. vascular smooth muscle
⑯ 종류 16. cancer stem cell
○ (+) ABCG2, ALCAM, ALDH1A1, BMI1, CD24, CD44, KIT, NANOG, NES, PDPN, POU5F1, PROM1, SOX2, THY1 (sc-type)
⑰ 종류 17. adventitial cell : pericyte의 특수한 서브타입
○ (+) TSKU, GFPT2, MFAP4, PCOLCE, SPOCK1, GPR133, PI16, GFRA1, FIBIN, PDGFRL (Tabula Sapiens)
⒀ 조직 12. adrenal stroma
① 종류 1. CSH1_CSH2 positive cell
○ (+) CGB, GH2, PSG5, CGA, CSH1, ERVW-1, CSH2, PSG7, PSG11, HSD3B1, PSG9, PSG1, PSG6, PLAC4, PSG4 (sc-type)
② 종류 2. megakaryocyte
○ (+) C15orf54, GP9, PF4, PPBP, GP1BA, MEGT1, LY6G6F, GP6, ITGA2B, C6orf25, ALOX12, FCER1A, ELOVL7, NRGN, RP11-930O11.1 (sc-type)
③ 종류 3. Schwann cell
○ (+) WNT16, MPZ, FOXD3, SOX10, CDH19, GPR17, PMP2, COL20A1, INSC, RP4-792G4.2, TTYH1, SOX2, LAMP5, OLFML2A, ATP1A2 (sc-type)
④ 종류 4. sympathoblast
○ (+) NPAS4, SLC24A2, RP11-542G1.2, PENK, LINC00890, KLK4, RP11-17A4.2, RP5-1096J16.1, C18orf42, TTC40, ARC, FAM19A3, VWA5B1, PPP1R17, RP4-718N17.2 (sc-type)
⑤ 종류 5. stromal cell
○ (+) MIR1245A, NPY5R, RP11-60A8.1, RP11-254F19.2, RP11-494K3.2, RP11-758M4.4, RP11-142A23.1, RP11-752L20.5, OSR1, RP11-867G23.13, SULT1E1, HHIP, MGP, PRELP, TWIST2 (sc-type)
⑥ 종류 6. chromaffin cell
○ (+) NRG1-IT3, RNU6-457P, LINC00594, AC018643.4, RP11-159N11.3, CTC-537E7.1, Y_RNA, snoU13, CTD-2006K23.2, RP5-955M13.4, INSRR, KCNK10, PHEX-AS1, RP11-958J22.1, FLJ30594 (sc-type)
⑦ 종류 7. adrenocortical cell
○ (+) RP1-145M24.1, RP11-238I10.1, AC005392.13, RP11-316I3.2, RP11-501O2.4, SDIM1, RP11-258O13.1, AJ006998.2, CTD-2517O10.5, RNU6-944P, CTB-43E15.4, RP11-34F13.3, RP11-536K7.5, RP11-183M13.1, RNU6-56P (sc-type)
⑧ 종류 8. SLC26A4_PAEP positive cell
○ (+) IL1A, SLC26A4, SNX25P1, VMO1, CTD-2210P15.2, CTC-360P9.4, ULK4P1, SNORA14A, RNU6-518P, RP11-431N15.2, RP11-26J3.3, RP11-378A12.1, SPINK8, HSD3B2, KIRREL-IT1 (sc-type)
⒁ 조직 13. heart stroma
① megakaryocyte
○ (+) MEGT1, LY6G6F, TUBB1, PPBP, PF4, GP9, TPSB2, HBD, AC137932.6, ITGA2B, GP1BA, CLEC1B, PTCRA, BEND2, RP11-179A10.1 (sc-type)
② epicardial fat cell
○ (+) RP11-89M22.3, CTD-3012A18.1, PRG4, KRT7, SPRR2F, KLK11, MKRN9P, UPK1B, EPGN, NPHS1, ITLN1, LRRN4, CST6, GSDMA, RAET1E (sc-type)
③ Schwann cell
○ (+) GFRA3, SOX10, MPZ, LINC00466, COL20A1, MIA, ASPA, ERBB3, TFAP2A, INSC, ARTN, PMP2, S100B, FOXD3, AP000797.3 (sc-type)
④ endocardial cell
○ (+) ANGPTL5, APCDD1L, NPPC, SLC6A4, SALL1, LEPR, C3orf36, AC004562.1, FAM3D, HAPLN1, APCDD1, LYPD2, FOXC1, MPZL2, RP11-849I19.1 (sc-type)
⑤ stromal cell
○ (+) RP11-60A8.1, SCARA5, DPT, CILP, ZCCHC5, AGTR2, MFAP5, RP11-71N10.1, LUM, ABCA10, RP11-31K23.2, CCL11, NRK, PDGFRA, LPAR4 (sc-type)
⑥ smooth muscle cell
○ (+) PDE4C, RP11-112H10.4, RP11-598F7.5, RP11-626H12.1, HCG22, CTD-3064M3.3, RP11-231I13.2, GPR20, RP11-267N12.1, OR51E1, THBS4, MIR143HG, PDGFRB, AOC3, ENPEP (sc-type)
⑦ SATB2_LRRC7 positive cell
○ (+) NEUROD2, FEZF2, NEUROD6, TBR1, MPPED1, SATB2, FOXG1, PCDH11Y, CAMKV, BHLHE22, SLIT1, C14orf23, RP11-562L8.1, LINC00966, DRAXIN (sc-type)
⑧ visceral neuron
○ (+) GATA3-AS1, GAL, CHRNA3, PRPH, PHOX2A, GALR1, NXPH1, TMC3, DDC, SST, OPRM1, PIRT, NECAB2, ECEL1, SLC10A4 (sc-type)
⑨ cardiomyocyte
○ (+) RP11-439H8.4, RNA5SP327, CTD-2552K11.2, Y_RNA, AC018464.3, HHATL, BMP10, RP11-461A8.4, UGT2B4, PRSS42, WI2-1896O14.1, FABP2, EPN3, RP11-406O23.2, AC009878.2 (sc-type)
⑩ ELF3_AGBL2 positive cell
○ (+) C1orf194, ZMYND10, MS4A8, IL20RA, ELF3, SCGB3A2, EFCAB1, SFTPB, WDR65, CP, PIH1D2, AGBL2, SFTPC, DNAH9, MUC1 (sc-type)
⑪ CLC_IL5RA positive cell
○ (+) FAM209A, CERKL, CLC, PRG2, MS4A3, IL5RA, ZC2HC1C, CTD-2620I22.1, CTD-3032H12.2, RP11-252E2.1, AC011524.1, S100A1, Y_RNA, LINC00407, RP11-516C1.1 (sc-type)
⑫ cardiac stem and precursor cell
⑬ cardiomyocyte
⑭ his bundle cell
⑮ Purkinje fiber cell
⒂ 조직 14. intestine stroma
① chromaffin cell
○ (+) ARX, NKX2-2, CCK, CRYBA2, NEUROD1, FEV, MLN, ASIC5, ONECUT3, SST, RP11-788H18.1, PAX4, KCNH6, SSTR5, PCSK1 (sc-type)
② smooth muscle cell
○ (+) ACTG2, GREM2, CNN1, RP11-467I20.6, WIF1, TACR2, OVCH2, FRMD6-AS2, DES, MYH11, RP11-626H12.1, ANO1, CHRDL2, TAGLN, FBXL22 (sc-type)
③ ENS glia
○ (+) SERPINA3, RLBP1, GPR12, RP4-792G4.2, CDH19, COL20A1, SOX10, PLP1, SOX2, FOXD3, MPZ, BCAN, TFAP2A, SOX2-OT, PTPRZ1 (sc-type)
④ ENS neuron
○ (+) PDIA2, RP11-672L10.2, GRP, DRGX, GCGR, SLC18A3, PHOX2A, HECW1-IT1, RP11-202H2.1, IQCJ, STMN4, TTC9B, GAL, CEND1, NEFL (sc-type)
⑤ stromal cell
○ (+) RP11-13P5.2, MSC, RP1-283K11.3, RP5-1077H22.1, CTD-2541J13.1, AC002511.2, AC002511.3, MMP27, CTD-2334D19.1, CXCL14, FZD10, PDGFRA, AC003090.1, RP1-288H2.4, ITGA11 (sc-type)
⒃ 조직 15. placenta stroma
① PAEP_MECOM positive cell
○ (+) RP11-98L5.2, AC104654.1, PAEP, RP11-274B18.4, PIGR, TSPAN1, AC012593.1, RP11-510D19.1, POU5F1, UGT2B7, DEFB1, RP11-697E22.2, SLC18A2, PAX8, SLPI (sc-type)
② AFP_ALB positive cell
○ (+) SLC2A2, ALB, APOB, AFP, ITIH2, F2, MAT1A, APOC3, SERPINC1, FABP1, APOA2, AHSG, SERPINA10, SLC38A3, SERPINA4 (sc-type)
③ extravillous trophoblast
○ (+) AC022596.6, GKN1, CILP2, LINC00330, PDE6H, PRG2, RP11-872D17.8, HLA-G, ASCL2, NOTUM, AC006262.5, DAW1, NOG, TAC3, RP11-420L9.4 (sc-type)
④ trophoblast giant cell
○ (+) CCK, CTA-833B7.2, PSG1, CGB, CSH2, PSG6, KISS1, INHBA, GH2, PSG9, CRH, PSG8, RP11-76E12.1, PSG4, TREML3P (sc-type)
⑤ smooth muscle cell
○ (+) RP11-162G9.1, FAM162B, WNT3A, AFF2, CDH19, SCN11A, GPR20, COX4I2, AGTR1, ADAMTS20, RP11-123O22.1, HIGD1B, AC020571.3, COLEC10, KCNK17 (sc-type)
⑥ IGFBP1_DKK1 positive cell
○ (+) RP3-404K8.2, RP11-486P11.1, FOXL2, WT1, RP11-171A24.3, SCARA5, LRRN4CL, S100A3, WT1-AS, PRL, WNT4, AC012065.7, APOD, BRINP2, RORB (sc-type)
⑦ stromal cell
○ (+) AP006285.6, AC002451.1, RP11-99L13.2, RP1-79C4.4, MMP23B, RP11-248N22.2, LA16c-380H5.4, MIR218-1, C8orf87, SNORD113, RP11-74M11.2, HSD3BP2, AP001605.4, LINC00314, AC007394.3 (sc-type)
⑧ syncytiotrophoblasts and villous cytotrophoblast
○ (+) CTD-2050E21.1, POTEKP, RP11-344B2.3, RP11-366M4.3, RP11-2A4.4, RP11-483F11.7, FTLP14, RP11-718G2.5, RP11-18D7.3, CLCA2, KB-1440D3.13, CTBP2P8, RP11-359P18.1, HSPD1P6, AC124861.1 (sc-type)
⑨ megakaryocyte
○ (+) EGF, TUBB1, PPBP, ITGA2B, RP11-930O11.1, RP11-152K4.2, LINC00989, PF4, C6orf25, LINC00534, PKHD1L1, NRGN, DNM3, RP11-466L17.1, RP11-142C4.6 (sc-type)
⒄ 조직 16. spleen stroma
① AFP_ALB positive cell
○ (+) SERPINA6, PLG, AMBP, SERPINC1, BHMT2, LBP, PRAP1, APOB, SERPINA1, FGB, VTN, SLC2A2, FGG, MT1G, ITIH1 (sc-type)
② stromal cell
○ (+) CTD-2270F17.1, ENPP7P4, AC105053.3, RP11-388K12.1, SCTR, KBTBD11-OT1, ADRA1B, NPM1P10, NPY5R, TPH2, CTC-535M15.2, MIR143HG, KLHL29, AC023481.1, CADPS (sc-type)
③ STC2_TLX1 positive cell
○ (+) CAMK2N2, CLVS2, RP11-384O8.1, FBXL16, GABRG2, HRK, EBF3, TRH, AC018730.1, CTD-3193O13.9, CPLX2, ATP1A3, TMEM119, IFI27L2, PET117 (sc-type)
④ megakaryocyte
○ (+) RAB27B, RP11-556I14.2, EGF, GP6, RP11-930O11.1, LINC00989, SELP, GP1BA, HPSE, RP11-152K4.2, LINC00504, MMRN1, ITGB3, ELOVL7, LY6G6F (sc-type)
⒅ 조직 17. stomach stroma
① neuroendocrine cell
○ (+) SLC18A1, GHRL, GAST, FEV, NKX2-2, CRYBA2, MBOAT4, CDK5R2, RFX6, HAP1, RP11-82C23.2, RBPJL, PTF1A, PAX6, CACNA1A (sc-type)
② parietal and chief cell
○ (+) RP11-467I20.6, ETNPPL, ATP4B, FGB, FGA, SIGLEC11, FRMD1, TRIM50, ALB, ATP4A, ANGPTL3, MFSD4, APOBEC2, CKM, PAQR5 (sc-type)
③ MUC13_DMBT1 positive cell
○ (+) ISX, GUCA2B, ENPP7, MIR194-2, BTNL3, TM4SF20, SI, SLC17A4, ALDOB, CDX1, DMBT1, CHP2, KRT20, SLC5A12, ADRA2A (sc-type)
④ goblet cell
○ (+) UGT2B15, IL17C, GKN2, SLC22A8, CXCL5, CSF3, TFF2, A4GNT, FBP2, FGF20, MUC6, GKN1, CXCL1, MUC5AC, CA9 (sc-type)
⑤ stromal cell
○ (+) AC002511.2, PTGER1, OSR2, AC003090.1, ACTG2, INHBA, HSPB6, AC131025.8, SHISA3, DPT, TRPA1, ACTA2, TWIST2, CXCL14, GLIS1 (sc-type)
⑥ ENS neuron
○ (+) PRPH, STMN2, ATP1A3, KCNIP4, NKAIN1, INA, GAP43, ATCAY, CNGB1, TCEAL5, STAC, DCX, RP11-457K10.1, FAM163A, CNTN5 (sc-type)
⑦ ENS glia
○ (+) SOX10, MPZ, ATP1A2, BAI1, PLP1, CDH19, COL20A1, ELOVL2, NOV, PRIMA1, RP11-308N19.1, SLC35F1, LGI4, VGLL3, EGFLAM (sc-type)
⑧ PDE1C_ACSM3 positive cell
○ (+) RP11-690G19.4, ACSM3, C1orf95, KCNE4, PDE1C, PSEN2, ERBB4, ATP6V0A4, TFCP2L1, WNK3, GABRB2, ADARB2, AMACR, SHISA2, NOX4 (sc-type)
⒆ 조직 18. thymus stroma (thyroid stroma)
① stromal cell
○ (+) PLAC9, LOX, MGP, COL1A2, COL5A3, COL1A1, ASPN, FGF18, MMP2, ISLR, DCN, SFRP2, COL3A1, SCARA5, COL6A6 (sc-type)
② thymocyte
○ (+) RP11-104L21.3, BEST3, HKDC1, KLRC4-KLRK1, RP11-305P22.9, LTA, TMSB15B, RP11-739G5.1, UBASH3A, PLK4, FBXO41, LIN28B, SKA3, CD40LG, AC002454.1 (sc-type)
○ (+) C1orf228, VIPR2, SLAMF1, CCR9, CHRM3-AS2, SMC4, LEF1, ARRDC2, BACH2, SCML1 (Tabula Sapiens)
③ follicular cell
⒇ 조직 19. bladder stroma
① fibroblast
② myofibroblast cell
③ pericyte
④ smooth muscle cell
⒇ 조직 20. reproductive system (e.g., prostate)
① decidual cell
○ (+) XCL1, IGFBP1, XCL2, CTSW, IL32, TRDC, KLRC1, PRL, AREG (PanglaoDB)
② germ cell
○ (+) DDX4, PRM1, ODF2, CRISP2, TCP11, PHF7, SPINK2, TSACC, PGK2, GTSF1, LELP1, MAEL, CCDC91, COX8C, FAM71E1, SPATA33, HMGB4, ROPN1L, TNP1, SMCP, LDHC, PRM2, DKKL1, MLF1, NR6A1, RSBN1L, DYNLT1, MRPL14, CREM (PanglaoDB)
③ granulosa cell
○ (+) AMH, INHA, TNNI3 (PanglaoDB)
④ Leydig cell
○ (+) INHA, DHCR7, CALB2, CYP17A1, CYP11A1, INSL3, LHCGR, STAR, PTGDS, HSD17B3, SMOC2, GJA1 (PanglaoDB)
⑤ Luteal cell
⑥ peritubular myoid cell
○ (+) SAT2, GSTM3, RNASE1, OSR2, MYL9 (PanglaoDB)
⑦ Sertoli cell
⑧ spermatocyte
○ (+) PRM1, PRM2, TNP1 (PanglaoDB)
⑨ spermatozoa
6. 유형 5. 기타 [목차]
⑴ embryo
① 종류 1. epiblast cell
② 종류 2. hemangioblast
③ 종류 3. trophoblast cell
④ 종류 4. trophoblast progenitor cell
⑤ 종류 5. trophoblast stem cell
⑥ 종류 6. embryonic stem cell (zygote)
⑵ 상태 1. EMT(epithelial-to-mesenchymal transition) : 전이의 주된 메커니즘
① (+) GATA3
② (-) DEFB4A, LCN2
⑶ 상태 2. MET(mesenchymal-to-epithelial transition)
⑷ 상태 3. EndMT(endothelial-to-mesenchymal transition)
⑸ 상태 4. MMT(mesothelial-to-mesenchymal transition)
⑹ 상태 5. MMT(monocyte-to-myofibroblast trans-differentiation)
입력: 2020.02.06 00:43
수정: 2023.08.27 00:48
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